S-CE-123-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemE(S)-CE-123Cat.No.:HY-163384CASNo.:2378384-49-5分子式:C₁₇H₁₅NOS₂分子量:313.44作用靶点:DopamineTransporter作用通路:NeuronalSignaling储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性(S)-CE-123是一种有效的、选择性的、新型非典型多巴胺转运蛋白(DAT)抑制剂，在稳定表达人DAT亚型的HEK293细胞中进行的摄取抑制测定中，EC50为2.76μM。(S)-CE-123是Modafinil类似物，能够透过血脑屏障。(S)-CE-123可以改善实验动物的认知和动机过程。体内研究(S)-CE-123(6.0,12.0,24.0mg/kg;ip;30minbeforetesting)significantlyattenuatestheeffectsofTBZ(Tetrabenazine;HY-B0590)onleverpressingandchowintake.(S)-CE-123alonehasnosignificantdifferencewithvehicle-treatedrats[1].AnimalModel:Trainedrats(adultmaleSprague-Dawleyrats)[1]Dosage:6.0,12.0,24.0mg/kgAdministration:IP;30minbeforetestingResult:AttenuatedtheeffectsofTBZ(1.0mg/kg)onleverpressingandchowintake.REFERENCESReneeARotolo,etal.TheNovelAtypicalDopamineUptakeInhibitor(S)-CE-123PartiallyReversestheEffort-RelatedEffectsoftheDopamineDepletingAgentTetrabenazineandIncreasesProgressiveRatioResponding.FrontPharmacol.2019Jun28:10:682.EduardoR.PerezGonzalez,etal.ProcessDevelopmentandScale-UpofaNovelAtypicalDATInhibitor(S)-CE-123.ACSOmega2024,March4.McePdfHeight1/1 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax: