神经生物学基础

神经生物学基础Tag内容描述：<p>1、精神疾病的神经生物学基 础及精神病药物作用机理 abnormal gene INHERITED DISEASE 100% will develop the inherited disease (classical autosomal dominant pattern) 4-1 Stahl S M, Essential Psychopharmacology (2000) abnormal gene product RISK FACTOR 1 an enzyme is too slow ever since birth so it is hard to metabolize neurotransmitters when release is very fast RISK FACTOR 2 some neurons migrated too far during development in utero RISK FACTOR 3 some of the wrong synapses were eliminated in adolescence R。</p><p>2、Immunoblotting analysis, immunocytochemical staining and double immunostaining in AD brain Oyagi, Asahara, Chui et al. FASEB J. 2005崔德华 DH Chui Summary (3) 1. Intracellular A42 directly activated the p53 promoter resulting in p53-dependent apoptosis. Remarkably, accumulation of both A42 and p53 was found in some degenerating-shape neurons in both mice and AD cases. Thus, the intracellular A42/p53 pathway may be directly relevant to neuronal loss in AD. 1. 1. Intracellular AIntracellular。</p><p>3、医学课件园 www.yxkjy.com,Motivation and Addiction,Neuroscience Exploring the Brain Chapter 16,吴鎏桢,WU Liuzhen researcher Neuroscience Research Institute, Peking University,医学课件园 www.yxkjy.com,The long-term regulation of feeding behavior by motivation (1)Energy Balance (2)hormonal,hypothalamic regulation of body fat, feeding (3)body fat and food consumption (4)the hypothalamus and feeding (5)the effects of decreased leptin level on the hypothalamus (6) the effects of elevated leptin level 。</p><p>4、医学课件园 www.yxkjy.com,脑的群电活动 (Ensemble Electric Activity) 与睡眠觉醒节律,罗非 教授 北京大学基础医学院神经生物学系 电话: 82801010; Email: fluobjmu.edu.cn Website: http:/nri.bjmu.edu.cn/ANnet,医学课件园 www.yxkjy.com,Before we start,动作电位是脑内唯一可以快速远距离传递的信号 神经元相互结合成电网络，同时也可按某种节律同步放电 群电活动可以通过表面或深部电极加以记录,医学课件园 www.yxkjy.com,Brain is Electric,脑内的电信号有 膜电位 动作电位 突触后电位 And a lot more,医学课件园 www.yxkjy.com,脑。</p><p>5、疼痛和抑郁： 抑郁的神经生物学,演讲内容,情绪和躯体的关联 疼痛和抑郁的“共病”机理 综合性医院抑郁的诊断和治疗目标 欣百达（度洛西汀）的对疼痛性躯体症状的疗效,演讲内容,情绪和躯体的关联 疼痛和抑郁的“共病”机理 综合性医院抑郁的诊断和治疗目标,抑郁症是世界范围内导致残疾的主要原因,Adapted from: Murray CJ, Lopez AD. Science 1996;274:740-743.,Evans DL, et al. J Clin Psychiatry. 1999;60(suppl 4):40-55. Evans DL, et al. Depress Anxiety. 1996;4(4):199-208.,躯体疾病患者中抑郁的患病率。</p>