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Craniomandibular Osteopathy pyrexia may be noted Rarely involves long bone, but in terriers lameness or limb swelling may precede changes in the skull nIf severe = restricted jaw movements (if fusion between the tympanic bullae pg 1977 (Note: also good radiographic images in Thrall 5th ed. 2007; pg 137) nDiagnosis: signalment, clinical signs, radiographic or CT findings nIn atypical cases (rarely affected breeds or unilateral lesions) bone biopsy may be helpful n n Self-limitingSelf-limiting abnormal bone proliferation slows, becoming static at skeletal maturity (1yr of age) Lesions may regress but radiographic abnormalities or prehensile dysfunction may remain nGuarded prognosis if changes to affected areas are severe with ankylosis and adhesions that permanently restrict jaw movement Craniomandibular Osteopathy (CMO) CMO Literature Review Computed Tomography of Craniomandibular Osteopathy in a Dog Cites reports of CMO in Great Dane, Boxer, and English Bulldog Brief discussion of similarities between CMO and infantile cortical hyperostosis or Caffey-Silverman syndrome in humans CT to determine extent of osseous involvement of tympanic bullae and angular processes of the mandible Elevations in serum ALP may coincide with periods of active disease In this case, lameness preceded involvement of skull. Presentation of a young Westie or Scottish terrier with periosteal involvement of the long bones may indicate future development of CMO. Recommend that these patients be monitored for changes consistent with CMO. VetRadUS, Vol. 35:2, 1994. pp 94-99 CMO Literature Review Canine Craniomandibular Osteopathy Journal of the Veterinary Radiology Society 1967; 8:23-31. nGood review of history, histopathologic changes, embryology of mandible, temporal bones, tympanic bullae and jaw nSummary of observations in 18 dogs (all terrier breeds) with craniomandibular osteopathy Clinical signs Radiographic signs Laboratory findings Gross anatomical appearance of skull lesions Microscopic description of bone changes nA syndrome of young male loss of fat from bone marrow is a relatively nonspecific change = fibrosis, sclerosis, hemosiderosis, or marrow infiltrate/replacement References nEttinger, Stephen J. and Edward C. Feldman. Textbook of Veterinary Internal Medicine Diseases of the Dog and Cat. 6th ed. Volume 2. Elsevier. St. Louis, MO:2005. pp1976-1980. nThrall, Donald E., DVM, PhD. Textbook of Veterinary Diagnostic Radiology. 5th ed. Saunders. St. Louis, MO:2007. pp135-136. nHudson, Judith A., DVM, PhD, Ron D. Montgomery, DVM, MS, John T. Hathcock, DVM, MS, and Joli M. Jarboe, DVM. Computed Tomography Of Craniomandibular Osteopathy In A Dog. Veterinary Radiology & Ultrasound 35:2, 1994. pp94-99. nRiser, Wayne H., D.V.M., M.S., Lincoln J. Parkes, D.V.M., and Jane F. Shirer, B.S., M.A. Canine Craniomandibular Osteopathy. Journal of the Veterinary Radiology Society 8, 1967. pp23-31. nMcConnell, J. F., A. Hayes, S. R. Platt, and K. C. Smith. Calvarial Hyperostosis Syndrome In Two Bullmastiffs. Veterinary Radiology & Ultrasound 47:1, 2006. pp72- 77. nFischetti, Anthony J., DV