不同治疗时机对妊娠梅毒的预后影响研究.doc

文章来源 毕业论文网 不同治疗时机对妊娠梅毒的预后影响研究文章来源 毕业论文网 【摘要】目的探讨不同时机妊娠梅毒治疗对患儿预后的影响。方法选取2008年1月2010年4月于我院进行生产治疗的妊娠梅毒患者80例为研究对象，将其随机分为a组（≤12周治疗组）20例、b组（1328周治疗组）20例、c组（≥29周治疗组）20例和d组（未治疗组）20例，将四组患者的足月分娩率、早产率、死胎率及低体重儿发生率、畸形率、apgar评分及母婴rpr滴度进行检测及比较。结果经研究比较发现，a组的足月分娩率高于b、c及d组，以d组最低，a组的早产率、死胎率及低体重儿发生率、畸形率均低于b、c及d组，以d组最高，a组1min及5minapgar评分均优于b、c及d组，母婴rpr滴度a组也最佳，其中a组中治疗2个疗程者母婴rpr滴度优于1个疗程者，p均0.05，均有显著性差异。结论早期的治疗对改善妊娠梅毒的预后有着积极的意义，因此主张早期的治疗。【关键词】  治疗时机；妊娠梅毒；预后；影响abstractobjectiveto discuss the effect of different curative opportunities on the prognosis of pregnant syphilis. methods80 cases with pregnant syphilis were randomly divided into 4 groups: group a (≤12 gestational weeks), group b (from 13 to 28 gestational weeks), group c (≥29 gestational weeks) and group d, 20 cases in each group; patients in group a, b and c received certain treatment but those in group d received no; the tem delivery rates, premature delivery rates, fetal death rat, occurrences of low weight infants, deformity rates, apgar scores and titers of rpr of mothers and infants were detected and a comparison was made among the 4 groups. resultsthe term delivery rate of group a was higher than those in group b, group c and group d, that of group d was the lowest; the premature delivery rate, fetal death rate, occurrence of low weight infants and deformity rate in group a were all lower than those in group b, group c and group d, those rates in group d were the highest; group a was superior in the 1st min and 5th min apgar scores to those in group b, group c and group d; the detection results of the titers of rpr of mothers and infants in group a were good, especially those of mothers and infants having 2 courses of treatment, even better than those of mothers and infants having 1 course of treatment (p0.05);the differences among the 4 groups were significant. conclusionsearly treatment has a positive effect on the prognosis of the patients with pregnant syphilis.keywordscurative opportunitypregnant syphilis prognosiseffect如何治疗以改善妊娠梅毒的预后非常重要，以往的报道也较多，但对于治疗时机的选择的报道较少1-2。本文中就不同治疗时机对妊娠梅毒的预后的影响进行研究，现将结果总结报道如下。1资料与方法1.1临床资料选取2008年1月2010年4月于我院进行生产治疗的妊娠梅毒患者80例为研究对象，将其随机分为a组（≤12周治疗组）20例、b组（1328周治疗组）20例、c组（≥29周治疗组）20例和d组（未治疗组）20例。a组的20例中，年龄2236岁，平均（26.8±3.2）岁，其中初产妇13例，经产妇7例，均于妊娠12周内进行治疗；b组的20例中，年龄2135岁，平均（26.2±3.7）岁，其中初产妇14例，经产妇6例，均于妊娠1328周内进行治疗；c组的20例中，年龄2034岁，平均（25.9±4.1）岁，其中初产妇12例，经产妇8例，均于妊娠29周及以后进行治疗；d组的20例中，年龄2337岁，平均（26.1±3.8）岁，其中初产妇13例，经产妇7例，均未进行治疗。四组患者在年龄及经、初产构成比方面比较，p均0.05，具有可比性。所有产妇均为单胎。1.2方法a组、b组及c组均采用苄星青霉素常规治疗方案进行治疗，给予患者苄星青霉素240万单位，肌内注射，1次/周，3次为1个疗程，其中部分患者进行第二疗程的治疗，第一与第二疗程间间隔2周3，过敏者采用盐酸四环素、红霉素等进行治疗4。后将四组患者的足月分娩