课件：餐后高血糖和心血管危险因素.ppt

Post Prandial Hyperglycemia: A Significant Cardiovascular Risk Factor & Treatable Precedent of Type 2 Diabetes,Diagnostic Criteria for Type 2 DM Pathophysiology of type 2 DM Post Prandial Hyperglycemia (PPH) and diabetic complications Prevention of Type 2 DM,The increasing global burden of diabetes,CVD drives the economic burden of type 2 diabetes,Pathophysiology of type 2 diabetes,Diagnosing glucose intolerance criteria reflect a need for early intervention,*Determined post 75g glucose load 2h-PG: 2-hour postchallenge plasma glucose, FPG: fasting plasma glucose, IFG: impaired fasting glucose, IGT: impaired glucose tolerance World Health Organization, 1999.,FPG and 2h-PG values identify different people with diabetes,The Relative Contribution of FPG and Mealtime Glucose Spikes to 24-hour Glycemic Level,Riddle MC. Diabetes Care 1990;13:676686,300 200 100 0,Plasma glucose (mg/dl),0600 1200 1800 2400 0600,Time (hours),Mealtime glucose spikes Fasting hyperglycemia Normal,Kuusisto et al, 1994,Glycemic Control and CHD,CHD Mortality,All CHD Events,A Comparison of Hba1c Levels Achieved in the Conventional Versus Intensive Groups of Major Trials,10 9 8 7 6 5,0 1 2 3 4 5 6 7 8 9 10,Time from randomization (years),HbA1c,DCCT,Kumamoto Study,9 8 7 6,0,0 3 6 9 12 15,Median HbA1c (%),Time from randomization (years),UKPDS,Conventional therapy Intensive therapy,12 11 10 9 8 7 6 5,0 12 24 36 48 60 72,Months,HbA1c (%),FPG = fasting plasma glucose; PPG = postprandial plasma glucose.,HbA1C,PPG,FPG,+,=,HbA1c (%),Fasting/2 hour plasma glucose (mg/dl),Harris MI et al Diabetes Care, 1998,Hba1c, Fasting and 2hr Plasma Glucose,UKPDS 10 yr-Cohort Data: Dissociation Between FPG & HbA1C,Del Prato S. 2001,Duration of Daily Metabolic Conditions,Postabsorptive,Fasting,Monnier L, Europ J Clin Invest, 2000,Intensive Treatment Policies,DCCT,Kumamoto,Study,UKPDS,Fasting plasma,glucose (mmol/l),3.9,6.7, 7.8, 6,2,-,hr pp glucose,(mmol/l), 10, 11,Not defined,The Funagata Cohort Population,*,*,*,*,*,*,*,*,*,*,Tominaga M et al. Diabetes Care, 1999,NGT - IFG - DM,The Funagata Cohort Population,*,*,*,*,*,*,*,*,*,*,Tominaga M et al. Diabetes Care, 1999,*,*,*,*,*,NGT - IGT - DM,Summary,1. Type 2 DM begins as a postprandial disease 2. Postprandial hyperglycemia contributes to elevations in HbA1c and complications 3. Treatment of postprandial hyperglycemia is critical to achieving optimal outcomes in type 2 DM 4. Nevertheless, treatment of postprandial hyperglycemia is inadequately addressed,STOP-NIDDM Study to Prevent Non-insulin Dependent Diabetes Mellitus,STOP NIDDM,Study design,STOP NIDDM,Acarbose reduces the risk of developing diabetes,STOP NIDDM,Acarbose has a rapid and sustained effect on diabetes risk,STOP NIDDM,Efficacy of acarbose is unaffected by baseline BMI or age,STOP NIDDM,Acarbose increases the reversion of IGT to NGT,STOP NIDDM,Acarbose an exceptional safety profile,STOP NIDDM,Acarbose reduces the risk of cardiovascular disease,STOP NIDDM,Reducing postprandial hyperglycaemia decreases the risk of diabetes and CVD,STOP NIDDM,Chinese studies support the efficacy of acarbose in patients with IGT,An emerging algorithm to manage IGT,Conclusions,后面内容直接删除就行 资料可以编辑修改使用 资料可以编辑修改使用 资料仅供参考，实际情况实际分析,主要经营：课件设计，文档制作，网络软件设计、图文设计制作、发布广告等 秉着以优质的服务对待每一位客户，做到让客户满意！ 致力于数据挖掘，合同简历、论文写作、PPT设计、计