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Name Email 3/7/2012,Journal Club,H2B ubiquitination mediated by Rad6/Bre1,H2A ubiquitination mediated by PRC1,Knockout Bmi-1 results in significant loss of H2A ubiquitylation and upregulation of Hoxc13 expression, whereas EZH2-mediated H3-K27 methylation is not affected. Our results suggest that EZH2-mediated H3-K27 methylation functions upstream of PRC1 and establishes a critical role for Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.,The stucture of 2A-HUB,nuclear receptor co-repressor 1,NR: nuclear receptors GPS2: G protein pathway suppressor 2 TBL1: transducin beta like 1,N-CoR: nuclear receptor co-repressor 1,Interaction between NCoR/HDAC1/3 components and 2A-HUB,2A-HUB mediated transcription repression,2A-HUB monoubiquitinates histone H2A in vitro,2A-HUB monoubiquitinates histone H2A in vitro,2A-HUB monoubiquitinates histone H2A in vivo,Conclusion 1,2A-HUB functions as a transcriptional repressor, and can specifically monoubiquitinate H2A in vitro and in vivo.,2A-HUB and N-CoR regulate a subset of chemokine gene expression,2A-HUB and N-CoR regulate a subset of chemokine gene expression,2A-HUB and N-CoR regulate a subset of chemokine gene expression,The recruitment of 2A-HUB and uH2A on the target gene promoters,Conclusion 2,2A-HUB and N-CoR regulate a subset of chemokine gene expression.,Coimmunoprecipitation of Spt16 and H2A/H2B,ChIP analysis of the endogenous RANTES promoter,ChIP analysis of the endogenous RANTES promoter,Model,Conclusion 3,H2A ubiquitination mediated by 2A-HUB negatively regulates transcriptional elongation by preventing FACT recruitment.,Summary,2A-HUB functions as a transcriptional repressor, and can specifically monoubiquitinates H2A in vitro and in vivo. 2A-HUB and N-CoR regulate a subset of chemokine gene expression. H2A ubiquitination mediated by 2A-HUB negatively