北京大学尚永丰院士实验室.doc

尚永丰院士实验室尚永丰教授 中国科学院院士 本实验室主要的研究方向包括三个方面：（1）乳腺癌、子宫内膜癌等性激素相关肿瘤发生发展的分子生物学机理；（2）基因表达调控的表观遗传学机制；（3）新基因的克隆、鉴定和功能分析。 本实验室研究工作由国家自然科学基金、国家科技部“973”、“863”重大专项课题等基金的资助。实验室现有年轻教工5名、博士研究生12名、博士后研究人员1名。实验室各成员严肃认真、勤奋刻苦，形成了一个团结战斗的大家庭。多年来，研究成果发表于Cell、Nature、Science、Molecular Cell、Nature Reviews Cancer、Genes & Development、PNAS、The EMBO Journal、EMBO Reports、Molecular and Cellular Biology、Cancer Research、Journal of Biology Chemistry、Oncogene等国际主流杂志。实验室以北京大学医学部“勤奋、严谨、求实、创新”的校训为宗旨，努力为研究生的培养和发展提供一个良好的环境，力争在学术上有所创新、有所发现。 尚永丰院士简介联系方式：电 话办公室）实验室）传 真mail: 简 历： 博士：美国宾夕法尼亚州立大学博士后：美国哈佛大学医学院主要职务： 北京大学基础医学院生物化学与分子生物学系主任 中国生物化学与分子生物学学会常务理事 中国生物化学与分子生物学学报副主编 科学通报（Chinese Science Bulletin）特邀编辑 Journal of Biological Chemistry编委获得基金： 2002年“国家杰出青年基金” 核受体对基因表达的调控及其在肿瘤发生发展中的作用(国家自然科学基金重大资助项目) 人类重要生理活性及具有药物开发前景的功能基因研究(国家“863”计划研究项目) 肿瘤和神经系统疾病的表观遗传机制(国家“973”计划研究项目) 乳腺癌、子宫内膜癌相关功能基因的应用研究(国家“863”计划研究项目) 肿瘤发生/发展的分子生物学和表观遗传学基础(国家自然科学基金创新研究群体科学基金) 新基因ZIP的转录调控功能及其在肿瘤发生中的作用(国家自然科学基金重点资助项目)研究方向： 乳腺癌、子宫内膜癌等性激素相关肿瘤发生发展的分子生物学机理 基因表达调控的表观遗传学机制 新基因的克隆、鉴定和功能分析近年来发表论文：（带*号的为责任作者） 1. Yan Wang, Hua Zhang, Yupeng Chen, Yimin Sun, Fen Yang, Wenhua Yu, Jing Liang, Luyang Sun, Xiaohan Yang, Lei Shi, Ruifang Li, Qian Li, Xia Yi, and Yongfeng Shang* (2009). LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell 138: 660-6722. Luyang Sun, Lei Shi, Wenqian Li, Wenhua Yu, Jing Liang, Hua Zhang, Xiaohan Yang, Yan Wang, Ruifang Li, Xingrong Yao, Xia Yi, and Yongfeng Shang* (2009). JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation. Proc Natl Acad Sci USA. 106: 10195-102003. Ruifang Li, Hua Zhang, Wenhua Yu, Yupeng Chen, Bin Gui, Jing Liang, Yan Wang, Luyang Sun, Xiaohan Yang, Yu Zhang, Lei Shi, Yanyan Li, and Yongfeng Shang* (2009). ZIP: a Novel Transcription Repressor, Represses EGFR Oncogene and Suppresses Breast Carcinogenesis. The EMBO Journal 28: 2763-27764. Jing Liang, Hua Zhang, Yu Zhang, Ying Zhang, and Yongfeng Shang* (2009). GAS, a new glutamate-rich protein, interacts differentially with SRCs and is involved in oestrogen receptor function. EMBO reports 10:51-575. Yupeng Chen, Lei Shi, Lirong Zhang, Ruifang Li, Jing Liang, Wenhua Yu, Luyang Sun, Xiaohan Yang, Yan Wang, Yu Zhang, and Yongfeng Shang*(2008). The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer. Journal of Biological Chemistry 283: 17969 179786.Dongwei Fan, Zhongqiang Chen*, Yupeng Chen, and Yongfeng Shang* (2007). Mechanistic roles of leptin in osteogenic stimulation in thoracic ligament flavum cells Journal of Biological Chemistry 282: 29958-299667. Yongfeng Shang* (2007) Hormones and cancer. Cell Research 17:277-279 (commentary via invitation) 8. Xin Li, Jing Liang, Haijing Yu, Bing Su, Chunjie Xiao, Yongfeng Shang*, Wen Wang* (2007). Functional consequences of new exon acquisition in mammalian chromodomain Y-like (CDYL) genes. Trends in Genetics 23: 427-431 9. Bin Shi1, Jing Liang1, Xiaohan Yang, Yan Wang, Youna Zhao, Huijian Wu, Luyang Sun, Ying Zhang, Yupeng Chen, Ruifang Li, Yu Zhang, Mei Hong, and Yongfeng Shang* (2007) . Integration of Estrogen and Wnt Signaling Circuits by the Polycomb Group Protein EZH2 in Breast Cancer Cells. Molecular and Cellular Biology 27: 5105-511910. Ying Zhang, Hua Zhang, Jing Liang, Wenhua Yu, and Yongfeng Shang* (2007). SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm. The EMBO Journal 26: 2645265711.Shaosi Li, Yongfeng Shang* (2007). Regulation of SRC Family Coactivators by Post-translational Modifications. Cellular Signalling 19: 1101-1112 (invited review)12.Hua Zhang, Luyang Sun, Jing Liang, Wenhua Yu, Ying Zhang, Yan Wang, Yupeng Chen, Ruifang Li, Xiaojing Sun, and Yongfeng Shang* (2006). The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription. The EMBO Journal 25: 4223-423313. Huijian Wu, Luyang Sun, Ying Zhang, Yupeng Chen, Bin Shi, Ruifang Li, Yan Wang, Jing Liang, Dongwei Fan, Ge Wu, Dan Wang, Shaosi Li, and Yongfeng Shang* (2006). Coordinated Regulation of AIB1 Transcriptional Activity by Sumoylation and Phosphorylation. Journal of Biological Chemistry 281: 21848-2185614.Yongfeng Shang* (2006). Molecular Mechanisms of oestrogen and SERMs in endometrial carcinogenesis. Nature Reviews Cancer 6: 360-368 (invited review)15.Huijian Wu, Yupeng Chen, Jing Liang, Bin Shi, Ge Wu, Ying Zhang, Dan Wang, Ruifang Li, Xia Yi, Hua Zhang, Luyang Sun, and Yongfeng Shang* (2005). Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis. Nature 438: 981-98716. Hua Zhang, Xia Yi, Xiaojing Sun, Na Yin, Bin Shi, Huijian Wu, Dan Wang, Ge Wu, and Yongfeng Shang* (2004). Differential Gene Regulation by the SRC Family of Coactivators. Genes and Development 18: 1753-176517. Na Yin, Dan Wang, Hua Zhang, Xia Yi, Xiaojing Sun, Bin Shi, Huijian Wu, Ge Wu, Xinjuan Wang, and Yongfeng Shang* (2004). Molecular Mechanisms Involved in the Growth Stimulation of Breast Cancer Cells by Leptin. Cancer Research 64: 5870-587518. Xiaojing Sun, Hua Zhang, Dan Wang, Yan Shen*, and Yongfeng Shang* (2004). DLP, A Novel Dim1 Family Protein Implicated in Pre-mRNA Splicing and Cell Cycle Progression. Journal of Biological Chemistry 279: 32839-3284719. Ma Han, Yongfeng Shang, DY Lee, and Michael Stallcup (2003). Study of nuclear receptor-induced transcription complex assembly and histone modification by chromatin immunoprecipitation assays. Methods in Enzymology 364: 284-29620.Zebin Mao, Song Shan, Yunyan Zhu, Xia Yi, Hua Zhang, Yongfeng Shang*, and Tanjun Tong* (2003). Transcriptional Regulation of A33 Antigen Expression by Gut-enriched Krppel-like Factor (GKLF). Oncogene 22: 4434-444321. Yongfeng Shang and Myles Brown (2002). Molecular determinants for the tissue specificity of SERMs. Science 295: 2465-246822. Yongfeng Shang, Molly Myers and Myles Brown (2002). The formation of androgen receptor transcription complex. Molecular Cell 9: 601-61023. Maricarmen D. Planas-Silva, Yongfeng Shang, Joana Liu Donaher, Myles Brown, and Robert A. Weinberg (2001). AIB1 enhances estrogen- dependent induction of cyclin D1 expression. Cancer Research 61: 3858-386224. Yongfeng Shang, Xiao Hu, James Direnzo, Mitch Lazar, and Myles Brown (2000). Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 103: 843-85225. James DiRenzo, Yongfeng Shang, Michael Phelan, Said Sif, Molly Yancisin, Robert Kingston, and Myles Brown (2000). BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation. Molecular and Cellular Biology 20: 7541-754926. Yongfeng Shang, Craig R. Baumrucker, and Michael H. Green (1999). Induction and activation of signal transducer and activator of transcription (STAT) 1 by all-trans-retinoic acid in breast cancer cells is mediated by RARb signaling pathways. Oncogene 18: 6725-673227. Yongfeng Shang, Craig R. Baumrucker, and Michael H. Green (1999). Signal relay by RARa and RARb in retinoic acid-induced IGFBP3 expression in breast cancer cells. Journal of Biological Chemistry274: 18005-18010 28. Yongfeng Shang, Craig R. Baumrucker, and Michael H. Green (1998). c-Myc is a major mediator of the synergistic growth inhibitory effects of retinoic acid and interferon in breast cancer cells. Journal of Biological Chemistry 273: 30608-30613中文杂志综述1. Yongfeng Shang*. Gene Regulation by Nuclear Receptors. 北京大学学报，2002年05期 2. 易霞，尚永丰*。生物芯片技术发展及应用前景，中国医院，2003年07期。 3. 易霞，尚永丰*。依赖ATP的染色质物理修饰，中国生物化学与分子生物学报，2003年04期。 4. 尹娜，王新娟，尚永丰*。中介因子复合体在基