Toxic chemical handling：有毒的化学处理.docx

STANDARD OPERATING PROCEDUREProcedure:Handling Toxic ChemicalsSchool/Department:School of Biological SciencesSOP prepared by: Dianne Fisher and Nick Coleman SMB edit M JosephSection 1 - Personal Protective Equipment 1. Safety Glasses or goggles (face shield if appropriate)2. Lab coat or gown3. Gloves (e.g. disposable latex or nitrile, refer to specific chemical MSDS for appropriate glove selection)4. Fully enclosed shoes (preferably leather) with non-slip soles5. Long pants or clothing to cover legs6. Chemicals absorbed by skin additional protective clothing such as oversleeves/apron to minimise further skin contact7. Full-face air-filter (respirator) may be required if working with toxic fine powders.Section 2 Potential Hazards + Safety precautions 1. Consult MSDS for potential hazards of a specific chemical it is essential that you know the risks of the chemicals you are working with *before* you begin hands-on work. Check with your supervisor if you are unsure about anything, especially if you are not sure the risks of the chemical can be adequately controlled. 2. Look for specific warning phrases such as “TOXIC”, “HIGHLY TOXIC”, “EXTREMELY TOXIC”, “CARCINOGENIC”, “MUTAGENIC”, “TERATOGENIC”. 3. Exposure to toxic chemicals by skin contact, inhalation, or ingestion may lead to immediate (acute) toxic effects, delayed (chronic) toxic effects, or sensitisation (allergic reaction). It is important to realise that toxic effects may only appear after a long period of exposure to the chemical. 4. Toxic chemicals may also have other hazardous properties such as “flammable”, “oxidiser”, “corrosive”, etc these properties should also be taken into account when storing/using chemicals. 5. Manipulation of toxic chemicals should be carried out in a working fume hood whenever possible. Access to safety shower and eyewash must be available in close proximity. Familiarise yourself with the locations of the shower and eyewash *before* you start work with toxic substances. 6. Very toxic substances (scheduled substances) or drugs (S4, S3) need to be kept locked up, and access to these restricted such that the general public cannot access themSection 3 Procedure1. Obtain and read MSDS for each toxic chemical to be handled.2. Know the location of spill kits, eyewashes, safety showers, fire extinguishers and fire blankets before starting work.3. Wear PPE, especially eye protection, lab coat and gloves, additional items such as filter mask, additional clothing may be required.4. Toxic chemicals should be manipulated and experiments conducted in a designated area with the appropriate hazardous warning labels.5. Manipulate toxic chemicals in a working fume hood (or glove box as required) in minimum amounts possible. Toxic liquids (e.g. organic solvents, aqueous solutions, etc.) should be dispensed using appropriate methods, e.g. automated pumps for large volumes, pipettes or dispensers for smaller volumes. Pre-weighed containers should be used to promptly weigh toxic solids.6. NEVER MOUTH-PIPETTE TOXIC LIQUIDS ! 7. Ensure all containers containing toxic chemicals are appropriately labelled with “name”, “concentration” and the warning “TOXIC”.8. Dispose of excess/unused toxic chemical waste into designated waste receptacles for disposal as hazardous wastes do not put down sink or into general waste. 9. Note: Cytotoxic waste must be segregated from all other waste streams and packaged in purple cytotoxic waste bags or cytotoxic sharps containers displaying the telophase cytotoxic symbol and the words CYTOTOXIC WASTE INCINERATE AT 1100 CELSIUS. The bags and sharps containers must then be placed into a Purple Cytotoxic Clinical Waste Bin. As the School does not have this system in place, please notify the Safety Officer if you intend to work with cytotoxic materials so that waste disposal can be arranged.10. Decontaminate/clean any spills on the outside of the container after use. Thoroughly decontaminate work area and equipment used.11. Wash hands and arms with soap and water immediately after handling toxic chemicals.Section 4 Spill Procedure and Waste Disposal1. Consult MSDS of specific chemical for spill procedure2. Keep an appropriate spill kit and appropriate PPE in lab and be informed how to use them (ensure you are properly trained). In some cases it may be appropriate to vacate the laboratory and call for assistance, especially in the event of a large spill of a toxic liquid or toxic fine powder. 3. Cleaning of spills will depend on chemical some toxic liquids may be able to be neutralised with other reagents, others liquids may be able to be absorbed with paper towel or left to evaporate overnight if in a fume hood. Any material used to clean up spills should be placed in a labelled plastic bag (eg. label ? spill waste TOXIC), then leave bag open in fume hood overnight to allow any residual vapours to disperse. Seal bag, and dispose of as hazardous chemical waste (See SOP/risk assessment for chemical waste). Solid waste should be carefully swept up using disposal material all waste should be deposited into plastic bag, sealed, labelled, and disposed of as hazardous chemical waste. Toxic waste must not go down sink or put into general waste.Section 5 First Aid1. First aid Consult MSDS of specific chemical for treatment advice2. Eye contact use emergency eye wash/shower and flush affected area on body (remove any jewellery) with copious amounts of water for at least 15 mins. Seek medical advice.3. Skin contact wash affected area with soap and water immediately.4. Inhalation Move exposed person to well ventilated area if safe to do so. Seek immediate medical advice.5. Ingestion Seek immediate medical advice.Section 6 Storage and transport1. Store toxic chemicals in a labelled and designated area consult individual chemicals MSDS for storage compatibilities with other chemicals.2. Acutely toxic chemicals must be stored securely. 3. Consult individual chemicals MSDS for transportation requirements.Section 7 Relevant Material safety data sheets & referencesConsult MSDS of specific chemical. Also see risk assessment for toxic chemicals, risk assessment and SOP for disposal of chemical waste. 1. WHSS website “Hazardous Waste Disposal Guidelines”.au/whs/guidelines/hazardouswaste/index.shtml2. WHSS website “Working with Chemicals” .au/whs/guidelines/chemical/hazsubs1.shtmlSOP Training Confirmation By signing below, these individuals confirm that they have read and understood the SOP, an