课件：靶向分子适配文献总结报告.ppt

Aptamer 应用文献总结,靶向药物传递,Aptamer-functionalized PEGPLGA nanoparticles for enhanced antiglioma drug delivery (2011,Biomaterials) AS1411 DNA aptamer 5-TTGGTGGTGGTGGTTGTGGTGGTGGTGG-3 胶质瘤细胞（C6 glioma cell ）,1、,PEGylated Anti-MUC1 Aptamer-Doxorubicin Complex or Targeted Drug Delivery to MCF7 Breast Cancer Cells（2011，Macrolecular Bioscience） MUC1 DNA aptamer 乳腺癌细胞（MCF7）,2、,Tumor targeted quantum dot-mucin 1 aptamer-doxorubicin conjugate for imaging and treatment of cancer（2011, Journal of Controlled Release） MUC1 DNA aptamer 5-GCA-GTT-GATCCT-TTG-GAT-ACC-CTG-G-3 卵巢癌细胞（ovarian ）,3、,Novel Aptamer-Nanoparticle Bioconjugates Enhances Delivery of Anticancer Drug to MUC1-Positive Cancer Cells In Vitro（2011，PolS ONE） A modified aptamer S2.2-spacer : 5-GCA GTT GAT CCT TTG GAT ACC CTG GTT CCC TTC CTT CTC TCT TCC TCT CTC CTT CTC TCT TCC TCT CTC CTT C-3 乳腺癌细胞（MCF-7）,4、,Aptamer-Conjugated DNAIcosahedral Nanoparticles As a Carrier of Doxorubicin for Cancer Therapy（2011，ACS NANO） MUC1 aptamer MCF-7,5、,Engineering of Targeted Nanoparticles for Cancer Therapy Using Internalizing Aptamers Isolated by Cell-Uptake Selection（2012，ACSNANO） XE02/XE06/XE09 A10 前列腺癌细胞（PC3 cell）,6、,A liposome-based nanostructure for aptamer directed delivery（2010, Chem. Commun） Sgc8 T淋巴细胞急性白血病细胞（CEM),7、,8、,Nanoparticle-Aptamer Bioconjugates: A New Approach for Targeting Prostate Cancer Cells （2010, Chem. Commun） A10 PMSM 前列腺癌细胞（PC3）,Quantum Dot-Aptamer Conjugates forSynchronous Cancer Imaging, Therapy, and Sensing of Drug Delivery Based on Bi-Fluorescence Resonance Energy Transfer（2007，NANO LETTERS） A10 PMSM 前列腺癌细胞（LNCaP cell）,9、,10、,Aptamer Biosensor Based on Fluorescence Resonance Energy Transfer from Upconverting Phosphors to Carbon Nanoparticles for Thrombin Detection in Human Plasma（2011,Analytical Chemistry） thrombin aptamer (5-NH2- GGTTGGTGTGGTTGG-3) 凝血酶,量子点、上转换荧光检测,Aptamer-functionalized magnetic nanoparticle-based bioassay for the detection of ochratoxin a using upconversion nanoparticles as labels（2011，Analyst） OTA aptamer 5-GAT CGG GTG TGG GTG GCG TAA AGG GAG CAT CGG-C6-biotin-3 赫曲霉素（OTA）,11、,2019/8/7,10,可编辑,靶向光热治疗、光动力治疗,Gold Nano-Popcorn Attached SWCNT Hybrid Nanomaterial for Targeted Diagnosis and Photothermal Therapy of Human Breast Cancer Cells（2011，ACS APPLIED MATERIALS &INTERFACES） S6 aptamer 乳腺癌细胞（SK-BR-3）,12、,Regulation of Singlet Oxygen Generation Using Single-Walled Carbon Nanotubes（2008，JACS） B细胞淋巴瘤细胞Romas cell,13、,14、,Aptamer-Based Tumor-Targeted Drug Delivery for Photodynamic Therapy（ACS NANO） AS1411 : 5GGTGGTGGTGGTTGTGG TGGTGG TGG-3 MCF-7,靶向基因治疗,Molecular imaging of a cancer-targeting theragnostics probe using a nucleolin aptamer- and microRNA-221 molecular beacon-conjugated nanoparticle（2012，Biomaterials） AS1411 5-GGTGGTGGTGGTTGTGGTGGTGG TGG3 胶质瘤细胞（C6 cell）,15、,药物缓释,One-pot synthesis of sustained-released doxorubicin silica nanoparticles for aptamer targeted delivery to tumor cells（2011，Nanoscale） sgc8c aptamer :5-NH2-ATC TAA CTG CTG CGC CGC CGG GAA AAT ACT GTA CGG TTA GA-3 T 细胞急性淋巴细胞白血病CCRF-CEM,16、,Stimuli-responsive releasing of goldnanoparticles and liposomes from aptamer functionalized hydrogel（2011，Nanotechnology） 腺苷,17、,A hybrid particlehydrogel composite for oligonucleotide-mediated pulsatile protein release（2010，Sof