[医学]传出神经系统药理英文睢大员.ppt

pharmacology,departmentofpharmacologyschoolofpharmacyjilinuniversitysuida-yuan睢大筼,whatisefferentnervoussystem(ens)?,chapter5pharmacologyofefferentnervoussystem,ceptor,effector,cns,ans,ens,（2）motornervoussystem,chapter5pharmacologyofens,section1structureandfunction,classificationofanatomy,（1）autonomicnervoussystemsympatheticnerveparasympatheticnerve,突触间隙synapticcleft,synapse,chapter5pharmacologyofens,section2transmitterandreceptor,transmitters,（1）noradrenaline(na)norepinephrin(ne),transmitters,synthesis,releasingandeliminationofna,synthesis,releasing,elimination,1,2,na,na,（2）acetylcholine(ach),chapter5pharmacologyofens,section2transmitterandreceptor,transmitters,ache,ach,synthesis,releasingandeliminationofach,synthesis,releasing,elimination,（2）adrenoceptorsreceptor：1and2receptor：1、2and3,chapter5pharmacologyofens,section2transmitterandreceptor,receptors,（1）cholinceptorsmuscarinereceptor(mr):m1andm2nicotinereceptor(nr)：n1andn2,（3）dopaminereceptors:d1andd2,（2）noradrenergicnerve(adrenergicnerve),chapter5pharmacologyofens,section2transmitterandreceptor,classificationoftransmitters,（1）cholinergicnerve,ach,chapter5pharmacologyofens,section3biologicaleffectandmechanism,biologicaleffectofens,seeundertable,chapter5pharmacologyofens,section3biologicaleffectandmechanism,molecularmechanismofbiologicaleffect,ligandgatedionchannelreceptor，regulatena+、k+、ca2+flux.,g-protein-coupledreceptors）,drugactionandsignaitransduction,chapter5pharmacologyofens,section4actionmannersandclassificationofdrugs,actionmanners,（1）direct:,（2）indirect:,agonistantagonist,affectreleaseaffecttransportandstorage,chapter5pharmacologyofens,section4actionmannersandclassificationofdrugs,classificationofdrugs,acetylcholine,chapter6cholinoceptoragonistsandcholinesteraseinhibitingdrugs,section1cholinoceptoragonists,1.m、n-cholinoceptoragonists,carbaylcholine,2.n-cholinoceptoragonists,nicotine,pilocarpine,chapter6cholinoceptoragonistsandcholinesteraseinhibitingdrugs,section1cholinoceptoragonists,3.m-cholinoceptoragonists,stimulatesm-receptor,3、m-cholinoceptoragonists,pilocarpine,1.eye,pharmacologiceffects,3.m-cholinoceptoragonists,pilocarpine,1.eye,a.miosis(constrictpupil),b.decreaseintraocularpressure,c.cyclospasm(spasmofaccommodation),circularmuscle,radialmuscle,3、m-cholinoceptoragonists,pilocarpine,1.eye,2.glandsincreasesecretionofsweatglandandsalivarygland,3.smoothmuscle,3.m-cholinoceptoragonists,pilocarpine,1.glaucoma,clinicaluses,open-angleglaucomaclose-angleglaucoma,2.iritis,chapter6cholinoceptoragonistsandcholinesteraseinhibitingdrugs,section2cholinesteraseinhibitors,reversiblecholinesteraseinhibitors,non-reversiblecholinesteraseinhibitors,neostigminephysostigmine,organophosphates,chapter6cholinoceptoragonistsandcholinesteraseinhibitingdrugs,section2cholinesteraseinhibitors,hydrolysisofach,ach,ache,choline,aceticacid,drugs,neostigmine,chapter6cholinoceptoragonistsandcholinesteraseinhibitingdrugs,section2cholinesteraseinhibitors,reversibleinhibitache,reversiblecholinesteraseinhibitors,ach,m-receptorn-receptor,reversiblecholinesteraseinhibitors,neostigmine,1.contractingskeletalmuscle,pharmacologiceffects,verystrong,-directactivatingn2receptors-releaseachatthemotornerveendings,2.stimulatinggitractandgallbladdersmoothmuscle,reversiblecholinesteraseinhibitors,neostigmine,1.myastheniagravis,clinicaluses,2.postoperativeileusandurinaryretention,cholinergiccrisis,3.paroxysmalsupraventriculartachycardia,4.overdosageofmusclerelaxants,reversiblecholiesteraseinhibitors,neostigmine,largedosage,adversedrugreaction,nausea,cholinergiccrisis,vomiting,abdominalpain,musclethrillorparalysis,reversiblecholinesteraseinhibitors,neostigmine,mechanicalintestinalobstruction,contraindications,urinaryobstruction,bronchialasthma,reversiblecholinesteraseinhibitors,physostigmine,eye,a.miosis,b.decreaseintraocularpressure,c.cyclospasm,reversiblecholinesteraseinhibitors,galanthamine,tensilon,tacrine,donepezil,chapter7cholinoceptorantagonists,1.m-cholinoceptorantagonists,2.n1-cholinoceptorantagonists,3.n2-cholinoceptorantagonists,depolarizingdrugs,nondepolarizingdrugs,succinylcholine,tubocurarine,m-cholinoceptorantagonists,atropine,pharmacologiceffects,1.inhibitingthesecretionofglandsalivaryglandsweatglandbronchialsecretaryglandstomachgland,m-cholinoceptorantagonists,atropine,pharmacologiceffects,2.relaxingvisceralsmoothmusclestomachintestinedetrusorofbladderurinarytractbronchialmusclebiliarytractuterus,m-cholinoceptorantagonists,atropine,pharmacologiceffects,3.eyemydriasisincreasesintraocularpressurecycloplegia,circularmuscle,radialmuscle,m-cholinoceptorantagonists,atropine,pharmacologiceffects,4.heartsmalldose:-decreasesheartratelargedose:-increasestheheartrate,m-cholinoceptorantagonists,atropine,pharmacologiceffects,5.dilatingbloodvesselsandimprovemicrocirculationtherapeuticdose:-nosignificanteffectlargedose:-dilatingbloodvessels,m-cholinoceptorantagonists,atropine,pharmacologiceffects,6.cnstherapeuticdose(0.51.0mg)maximaldose(1.02.0mg)morelargedose(2.05.0mg)toxicdose(over10mg),m-cholinoceptorantagonists,atropine,clinicaluses,1.relievingspasmofsmoothmuscle-visceralcolicpain,gastricandintestinalcolicpainbladderirritatingsymptomsgallbladdercolicpainrenalcolicpain,m-cholinoceptorantagonists,atropine,clinicaluses,2.inhibitingsecretionofgland,preanaestheticmedicationforcontrollingthesideeffectofetherseverenightsweatandslaversadjunctivetherapyforpepticulcers,m-cholinoceptorantagonists,atropine,clinicaluses,3.ophthalmology,iridocyclitisexaminingeyegroundexaminingeyesight,m-cholinoceptorantagonists,atropine,clinicaluses,4.cardiovasculardisorder,slowtypearrhythmia-bradycardia,s-ablock,a-vblock-adams-stokessyndromeinducedbyantimonyintoxication,m-cholinoceptorantagonists,atropine,clinicaluses,5.antishock,6.organophosphateintoxication,m-cholinoceptorantagonists,atropine,adversedrugreaction,contraindications,glaucoma,pyloricobstruction,prostatichypertrophy,usewithcaution,oldpeople,m-cholinoceptorantagonists,anisodamine(654-2),scopolamine,chapter8adrenoceptor-activatingdrugs,catechol,catecholamines,ca,adrenoceptor-activatingdrugs,1.-receptoragonists,2.、-receptoragonists,3.-receptoragonists,4.dopaminereceptoragonists,noradrenaline,metaraminol,adrenaline,ephedrine,isoprenaline,dobutamine,salbutamol,dopamine,、-adrenoceptoragonists,adrenalineadr,epinephrine,pharmacologiceffects,1.stimulatingtheheartcontractionforceheartrateconduction,co,2.contractandrelaxbloodvesselsskin,mucousmembranes-constrictionsplanchnicvesselsrenalandmesenteric-constrictioncerebralandpulmonary-weakconstrictionskeletalmuscle-dilatationcoronaryarteryvessels-dilatation,3.bloodpressure(1)systolicbloodpressure(2)diastolicbloodpressuresmalldose=largerdose,4.relaxationofbronchialsmoothmuscle5.metaboliceffects-increasemetabolism-energy-increaseinsulinsecretion-increaseoxygenconsumption,1.cardiacarrest2.allergicshock3.bronchialasthma4.localapplication,clinicaluses,hypertensionsclerosisofcerebralarteryischemicheartdiseasecongestiveheartfailurehyperthyreadiabetes,adversedrugreaction,contraindications,ephedrine,pharmacologiceffects,-similartoadrenaline-actionisweakandlonger-enhancesthereleaseofna-centralactions,-preventhypotension-bronchialasthma-nasalcongestion-allergy,clinicaluses,dopamine,pharmacokinetics,-precursorofnaandadr-metabolizedbycomtandmao-enhancesthereleaseofna-noeffectwithp.o.(ivggt)-noeffectoncns(notpenetratebbb),pharmacologiceffects,lowdose(1)increasecardiaccontractility-1+nareleasesbp(2)vasoconstriction(1)dbp=vasodilation(d1)(3)increaseinglomerularfiltrationrate,renalbloodflowandna+excretion(d1)largedose1d1,(1)sometypesofshock-cardiogenic,septicshockandhemorrhagicshockespeciallywithcardiacdysfunction,oliguriaoranuria(2)acuterenalinsufficiency-withdiuretics(3)congestiveheartfailure,clinicaluses,-adrenoceptoragonists,noradrenalinena,norepinephrine,pharmacologiceffects,1.stimulatingtheheart2.contractbloodvessels3.increasingbloodpressure,1.hypotension2.earlyphaseofneurogenicshock3.uppergastrointestinaltractbleeding,clinicaluses,hypertensionatherosclerosiscoronaryheartdiseaseoliguriaandanuria,adversedrugreaction,contraindications,metaraminol,pharmacologiceffects,-actson1receptor-causesnarelease-increasesbpandcardiacoutput-decreasesheartrate,-adrenoceptoragonists,isoprenaline,isoproterenol,pharmacologiceffects,1.stimulatingtheheart2.relaxbloodvessels3.decreasingbloodpressure4.relaxationofbronchialsmoothmuscle5.metaboliceffects,1.bronchialasthma2.cardiacarrest3.atrioventricularconductionblock4.shock,clinicaluses,coronaryheartdiseasemyocarditishyperthyroidism,adversedrugreaction,contraindications,naadrisoda,min,peripheralresistance,arterialpressure,pr,拟肾上腺素药基本作用的比较,1、2-receptoragonistsphentolamine,tolazoline,phenoxybenzamine1-receptoragonistsprazosin,dorazosin,terazosin,chapter9adrenoceptorblockingdrugs,s1.-receptorantagonists,s2.-receptorantagonists,1、2-receptoragonistspropranolol,timolol,pindolol1-receptoragonistsatenolol,metoprolol,acebutolol,s1.-receptorantagonists,blockreceptor,antagonizetheeffectsof-agonistsafterpretreatmentwith-antagonist-adrshowsdecreasebpcalled“epinephrinereversal”,1、2-receptorantagonists,phentolamine,pharmacologiceffects,1.reducesperipheralresistance-block1-relaxbloodvessels2.cardiacstimulation-reflexcardiacmechanisms-blockspresynaptic2enhancednarelease3.m,h1,h2agonist,1.periphera