Ambroxol aerosol inhalation 69 cases of bronchial pneumonia in children observed_41197.doc

ambroxol aerosol inhalation 69 cases of bronchial pneumonia in children observed标签:作者标签:来源标签:时间 abstract objective to observe ambroxol hydrochloride inhalation aerosol effect of bronchial pneumonia in children. methods 136 cases of patients with children were randomly divided into treatment group and control group were given conventional treatment such as antibiotics and symptomatic treatment group increased inhalation of oxygen-driven pumps applications ambroxol hydrochloride injection, the control group received inhalation of oxygen-driven pump chymotrypsin treatment. results the total effective rate was 91.30% in the control group, the total effective rate was 77.61%, compared the two groups significant difference (p 0.05), treatment group was significantly better than the control group. conclusion ambroxol aerosol inhalation bronchitis in children is good. keywords: ambroxol hydrochloride; bronchial pneumonia; children bronchial pneumonia is a common pediatric respiratory system, frequently-occurring disease, patients showed different degrees of fever, cough, asthma and other symptoms. our department from february 2008 to december 2009 application of ambroxol (ambroxol) fog inhalation of 69 cases of bronchial pneumonia in children, and achieved satisfactory results, are summarized below. materials and methods 1. general information all from the hospital 136 cases of pediatric patients hospitalized patients, diagnosis diagnostic criteria 1, randomly divided into two groups. the treatment group 69 cases, male 40 cases, female 29, age 8 months to 13 years (mean 4.73 + -1.15) years; the control group 67 cases, 37 males and 30 females, aged 8 months to 12 years (mean 4.86 + -1.33 years). two children in the age, gender, disease duration was no significant difference (p 0.05), no respiratory failure, heart failure complications. 2. treatment groups were routinely given antibiotics, cough, asthma, fever, correct water and electrolyte balance, combined therapy, the treatment group in the above treatment based on the use of oxygen inhalation-driven pump ambroxol hydrochloride injection 7.5 mg, 2 times a day, every 15 20 min, used in conjunction 7 d; the control group were treated with inhalation of oxygen-driven pump chymotrypsin 1000 2000 u, 2 times a day, every 15 20 min, for 7 d. 3. efficacy of standard clinical cure: 7 d after treatment, normal body temperature, cough and asthma disappeared, lungs rales disappeared, review the chest x-ray photograph showed the infection foci, or was absorbed completely. improvement: the treatment 7 d after the normal body temperature, cough reduce asthma, significantly reduced both lungs rales, review the chest x-ray photograph showed significant absorption of infected lesions improved. invalid: 7 d after treatment, admission symptoms, signs were not improved, reviewed the chest x-ray photograph showed no absorption in infected lesions or even worse. 4. pems 3.0 statistical package was used for statistical analysis, the total effective application of the two groups chi-square test, p 0.05 as significant difference. links to research papers download http:/ results treatment group, 46 cases of clinical cure, improvement in 17 cases, 6 cases, total effective rate was 91.30%; control group, 32 cases of clinical cure, improvement in 20 cases, 15 cases ineffective, the total effective rate was 77.61%, total effective rate between the two groups by chi-square test, ?2 = 4.881, significant difference (p 0.05). discussions and more children with bronchial pneumonia caused by bacteria or viruses, symptoms of fever, cough, sputum, asthma and so on. immature respiratory system in children mature small airway lumen, thin mucosa, lymph nodes, blood vessel rich, easy-to-infection, but the expectoration is weak. once the infection, respiratory secretions increase, easily lead to airway obstruction. treatment of phlegm as quickly as possible on how to maintain airway patency is a critical treatment of the disease. endopeptidase with chymotrypsin enzyme, the protein molecules of the peptide chain cut into smaller molecular weight peptides, proteins or peptides in the side effect in that the protein molecules break down the amino acids, digestible pus, plot blood, necrotic tissue from the wound clean, digestion, inflammation, swelling effect, due to its stability has been widely used in clinical efficacy. ambroxol hydrochloride bromine has a new metabolite in the body, is a novel expectorant 2. research shows that the ciliated epithelium can promote the regeneration and restoration of normal function of cilia, mucociliary movement speed, so as to maintain self-purification of the respiratory tract against harmful factors, injury, and has strong adhesive dissolving secretions and to promote sputum discharge characteristics, it can make sputum acid mucopolysaccharide fibers break down, and inhibition of bronchial mucous gland and goblet cells in the acid glycoprotein synthesis, so that the acid mucopolysaccharide composition of sputum in one of the sialic acid content reduce, reduce sputum viscosity, so that diluted sputum, promoting the airway and reduce the discharge of thick mucus secretions retention, which could significantly promote expectoration, significantly reduce the sputum volume, respiratory mucosa of surfactant which can play its normal protective function, mucus secretion is also restored the normal state 3. ambroxol inhalation of people with breathing disorders in infants, can increase the tidal volume per kilogram, significantly relieve airway obstruction in the respiratory tract, small airway obstruction partial remission 4. the treatment group, inhalation of oxygen-driven pump ambroxol, formed by atomization of drug particles into the respiratory tract with breathing in children, the local lesions, in particular the elimination of deep inflammatory lesions and sputum clearance played a a more effective role than simply a good anti-infection therapy. the simple, easy to accept patients, the course of treatment no significant adverse reactions, easy application. ref