硕士学位论文模板.doc

分类号：学校代码： 10438密 级： 学 号： 硕士学位论文题目HIF-1、VEGF、uPA在胶质瘤中的表达及其与血管生成的关系院、系（所）临 床 学 院专业外 科 学学位类型医 学 专 业 学 位研究生 导师 教授 教授 论文起止日期: 2006年03月-2007年04月17潍坊医学院硕士学位论文目 录一、中文摘要1二、英文摘要3三、符号说明5四、正 文（一）前 言6（二）材料和方法7（三）结 果10（四）讨 论12（五）结 论29五、附图表30六、参考文献37七、文献综述42八、致 谢50九、攻读学位期间撰写的论文51十、学位论文原创性声明及使用授权声明52HIF-1、VEGF、uPA在胶质瘤中的表达及其与血管生成的关系研 究 生：专 业：导 师：中文摘要THE EXPRESSION OF HIF-1，VEGF AND UPA INGLIOMAS ANDTHE RELATION WITH ANGIOGENESISPostgraduateSpecialitySupervisor Professor Professor ABSTRACT符 号 说 明英文缩写英文全称中文全称前 言材料与方法结 果讨 论结 论附 图 表参考文献1 王忠诚主编神经外科学M第一版，武汉：湖北科学技术出版社, 1998: 397-399.2 Zetter BR.Angiogenesis and tumor metastasisJ.Ann Rev Med,1998,49,407-414.3Zagzag D, Friedlander DR, MargolisB et al. Molecular evens implicated in brain tumor angiogenesis and invasion J.Pediatr Neurosurg 2000,33(1):49-55.4 Zhong H, De Marzo AM, Laughner E. Overexlmession of hypoxia-inducible factor lalpha in common human cancers and theirmetastasesJ.Cancer.1999.59: 5830-5835.5 Zagag D, Zhong H, Scalziti JM. Exorosion of hvooxia-inducible factor 1 alpha in brain tumors association with anmo Qenests-invision and progressionJ. Cancer. 2000.88: 26-28.6 许良中,杨文涛.免疫组织化学反应结果的判断标准J. 中国癌症杂志，1996, (4): 29-31.7Bergers G, Benjamin LE. Tumor igenesis and the angiogenic switchJ. Nat Rev Cancer, 2003, 3(6): 401-410.8Zhang X, Yamashita M, Uetsuki H, et al. Angiogenesis in renal cell carcinoma: Evaluation of microvessel density, vascular endothelial growth factor and matrix metalloproteinasesJ. Int J Urol, 2002,9(9): 509-514.9Konno H, Baba M, Shoji T, et al. Cyclooxygenase-2 expression correlates with uPAR levels and is responsible for poor prognosis of colorectal cancerJ. Clin Exp Metastasis, 2002,19(6): 527-534.10 Maniotis AJ, Folberg R, Hess A, et al. Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicryJ. Am J Pathol, 1999, 155(3): 739-752.11Robert F, May J, Hendrix C. Maniotis: Vasculogenic Mimicry and Tumor Angio- genesis J. Am J Pathol,2000,156(2): 361-381.12Angela RH, Elisabeth AS, Lynn MG, et al. Molecular Regulation of Tumor Cell Vasculogenic Mimicry by Tyrosine Phosphorylation: Role of Epithelial Cell Kinase (Eck/EphA2)J. CancerRes,2001,61:3250-3255.13Brekken RA, Overholser JP, Stastny VA, et al. Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2(KDR/Flk-2) activity by a monoclonal anti-VEGF antibody blocks tumor growth in miceJ. Cancer Res, 2000, 60(18): 5117- 5124.14McMahon GA, Petitclere E, Stefansson S,et al. Plasminogen activation inhibitor-1 regulates tumor growth and angiogenesis J. Biol Chem, 2001, 276(36): 33964-33968.15Cronauer MV, Schulz WA, Seifert HH,et al. Fibroblast growth factors and their receptors in urological cancers: basic research and clinical implicationsJ. Eur Urol. 2003, 43(3):309-319.16 Birner P, Gatterbauer B, Oberhuber G, et al. Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas:its impact on prognosis and on neoangiogensis J. Cancer,2001,92(1): 165.17Zhong H, DeMarzo AM, Laughner E, et al. Overexpression of hypoxia indu- cible factor 1alpha in common human cancers and their metastasesJ.Cancer Res,1999,59(22):583.18 高文昌,于如同,潘昕,等.脑胶质瘤HIF-1、CD34表达与预后的关系J.实用临床医药杂志,2004,8 1:24-26.19郭克勤,于如同,高文昌.HIF-1、VEGF表达与脑胶质瘤预后的相关性J.徐州医学院学报, 2003,23(3):228-230.20 朱宏. 缺氧诱导因子与肿瘤血管生成J.国外医学肿瘤学分册,2004, 318: 24-26.21Korkolopoulou P, Patsouris E, Konstantinidiu AE, et al. Hypoxia-inducible factor 1alphavascular endothelial growth factor axis in astrocytomas. Associations with microvessel morphometry,prolife ration and prognosisJ.Neuropathol Appl Neurobiol. 2004,30(3):267-278.22陈治.缺氧诱导因子-1的研究与应用进展J.国外医学生理病理科学与临床分册, 2004,241:34-37.文献综述致 谢攻读学位期间撰写的论文学位论文原创性声明本人声明，所呈交的学位论文系在导师指导下本人独立完成的研究成果。文中依法引用他人的成果，均已做出明确标注或得到许可。论文内容未包含法律意义上已属于他人的任何形式的研究成果，也不包含本人已用于其它学位申请的论文或成果。本文如违反上述声明，愿意承担以下责任和后果：1、交回学校授予的学位证书；2、学校可在相关媒体上对作者本人的行为进行通报；3、本人按照学校规定的方式，对因学位论文不当取得学位而给学校造成的名誉损害进行公开道歉；4、本人负责因论文成果不实产生的法律纠纷。论文作者签名：_ 签字日期： 年 月 日学位论文版权使用授权书本学位论文作者完全了解潍坊医学院有关保留、使用学位论文的规定，同意学校保留并向国家有关部门或机构送交论文的复印件和电子版，允许