高分子磁性微球的制备.doc

高分子磁性微球的制备 Polymer preparation of magnetic microsphere 姓名：田超 学号：0943012008 指导老师：胡静 课序号4检索词中文：高分子 磁性 微球 制备英文：polymer magnetic microsphere preparation中文数据库1、维普数据库检索式： T=高分子*M=磁性*R=微球*U=制备输出结果 1、磁性高分子复合微球的制备 作者 梁方毅 顾顺超 周锦鑫机构 上海交通大学化工系,上海200240 刊名 材料导报：纳米与新材料专辑-2010(2).-170-173 关键词 磁性高分子复合微球 硅烷偶联剂 悬浮聚合 粒径分布 ISSN 分类号 TB34文摘 通过选用含有乙烯基的有机硅烷偶联剂对自制的纳米Fe3O4进行表面修饰后，采用悬浮聚合法成功制备了单分散磁性高分子复合微球，并重点研究了分散剂浓度、搅拌速度、磁含量等因素对制备的磁性高分子复合微球的影响。结果表明，合适的分散剂浓度和搅拌速度可以获得球径分布良好的磁性高分子复合微球，微球的磁感应强度可以通过改变Fe3O4磁性粒子的含量进行调节。相关文献 主题相关 2、药物载体磁性高分子微球的制备及应用研究进展 作者 宋佳 朱春山 张强 邱莉机构 河南工业大学化学化工学院,河南郑州450001 刊名 辽宁化工-2010.39(8).-820-823 关键词 药物载体 磁性高分子微球 研究进展 ISSN 1004-0935分类号 TQ460文摘 介绍了药物载体磁性高分子微球的研究现状，总结了常用的制备方法及应用进展，展望了磁性高分子微球的发展前景。相关文献 主题相关 3、反相悬浮法制备磁性高分子微球的研究 作者 李春蛟1 林志勇2 钱浩2机构 1华侨大学化工学院 2华侨大学李希料科学与工程学院,福建厦门361021 刊名 化学工程与装备-2010(8).-30-33 关键词 磁性高分子微球 聚乙烯醇 戊二醛 反相悬浮法 ISSN 1003-0735分类号 TQ633文摘 本文采用反相悬浮法,通过聚乙二醇的缩醛化反应,制备了具有灵敏磁响应性、表面富含羟基的微米级的磁性高分子微球。主要探讨了反应时间、聚乙烯醇浓度、搅拌速度、戊二醛（GA）用量及磁流体用量的变化对磁性高分子微球制备及性质的影响,用红外（FTIR）、激光粒径分析仪、扫描电子显微镜（SEM）、振动样品磁强计（VSM）进行表征。结果表明,所制备磁球表面羟基含量高,分散性好,磁含量高,具有超顺磁性。相关文献 主题相关 4、大孔磁性高分子微球的制备及应用 作者 陈莉机构 广东省国际工程咨询公司 刊名 广东建材-2010.26(8).-16-18 关键词 磁性微球 悬浮聚合法 磁性性能 ISSN 1009-4806分类号 TQ586.1文摘 向苯乙烯希和二乙烯笨中加入一定量的-Fe2O3，采用悬浮聚合法制备磁性微球，可以得到含128-Fe2O3,比表面积为3234m2g，平均孔径为695Am的聚内乙烯磁性微球，电镜湿微照片显示其内部为多孔性蜂窝状结构。磺化后得到磺酸型刚离子微球，其交换容量为322megg。此种磁性微球具有一定的耐碱性利抗氧化性。相关文献 主题相关 5、生物高分子磁性微球的制备及靶向给药应用 作者 刘尚莲1 崔晗2机构 1健雄职业技术学院化学工程系,江苏太仓215411 2辽宁出入境检验检疫局技术中心庄河分中心,辽宁大连116400 刊名 化工时刊-2010.24(7).-34-38 关键词 磁效应 生物相容性 靶向给药载体 ISSN 1002-154X分类号 TQ460.4文摘 生物高分子磁性微球因具有磁效应、生物相容性和多种反应活性功能基团等特性，使其能广泛应用于生物医学、细胞学和生物工程等领域。综述了近年来生物高分子磁性微球的制备方法以及作为靶向给药载体的应用。相关文献 主题相关 T=高分子*K=磁性*R=微球+制备输出结果6、磁性高分子复合微球的制备 作者 梁方毅 顾顺超 周锦鑫机构 上海交通大学化工系,上海200240 刊名 材料导报：纳米与新材料专辑-2010(2).-170-173 关键词 磁性高分子复合微球 硅烷偶联剂 悬浮聚合 粒径分布 ISSN 分类号 TB34文摘 通过选用含有乙烯基的有机硅烷偶联剂对自制的纳米Fe3O4进行表面修饰后，采用悬浮聚合法成功制备了单分散磁性高分子复合微球，并重点研究了分散剂浓度、搅拌速度、磁含量等因素对制备的磁性高分子复合微球的影响。结果表明，合适的分散剂浓度和搅拌速度可以获得球径分布良好的磁性高分子复合微球，微球的磁感应强度可以通过改变Fe3O4磁性粒子的含量进行调节。相关文献 主题相关7、药物载体磁性高分子微球的制备及应用研究进展 作者 宋佳 朱春山 张强 邱莉机构 河南工业大学化学化工学院,河南郑州450001 刊名 辽宁化工-2010.39(8).-820-823 关键词 药物载体 磁性高分子微球 研究进展 ISSN 1004-0935分类号 TQ460文摘 介绍了药物载体磁性高分子微球的研究现状，总结了常用的制备方法及应用进展，展望了磁性高分子微球的发展前景。相关文献 主题相关8、反相悬浮法制备磁性高分子微球的研究 作者 李春蛟1 林志勇2 钱浩2机构 1华侨大学化工学院 2华侨大学李希料科学与工程学院,福建厦门361021 刊名 化学工程与装备-2010(8).-30-33 关键词 磁性高分子微球 聚乙烯醇 戊二醛 反相悬浮法 ISSN 1003-0735分类号 TQ633文摘 本文采用反相悬浮法,通过聚乙二醇的缩醛化反应,制备了具有灵敏磁响应性、表面富含羟基的微米级的磁性高分子微球。主要探讨了反应时间、聚乙烯醇浓度、搅拌速度、戊二醛（GA）用量及磁流体用量的变化对磁性高分子微球制备及性质的影响,用红外（FTIR）、激光粒径分析仪、扫描电子显微镜（SEM）、振动样品磁强计（VSM）进行表征。结果表明,所制备磁球表面羟基含量高,分散性好,磁含量高,具有超顺磁性。相关文献 主题相关9、大孔磁性高分子微球的制备及应用 作者 陈莉机构 广东省国际工程咨询公司 刊名 广东建材-2010.26(8).-16-18 关键词 磁性微球 悬浮聚合法 磁性性能 ISSN 1009-4806分类号 TQ586.1文摘 向苯乙烯希和二乙烯笨中加入一定量的-Fe2O3，采用悬浮聚合法制备磁性微球，可以得到含128-Fe2O3,比表面积为3234m2g，平均孔径为695Am的聚内乙烯磁性微球，电镜湿微照片显示其内部为多孔性蜂窝状结构。磺化后得到磺酸型刚离子微球，其交换容量为322megg。此种磁性微球具有一定的耐碱性利抗氧化性。相关文献 主题相关10、含羧基的磁性高分子微球的制备和表征 作者 王胜碧机构 安顺学院化学与生物农学系,贵州安顺561000 刊名 安顺学院学报-2009.11(6).-82-86 关键词 磁流体 分散聚合法 磁性高分子微球 ISSN 1673-9507分类号 O6-3文摘 在共沉淀法合成超细磁粉的基础上,以苯乙烯（St）为单体,过氧化苯甲酰（BPO）或过硫酸钾（KPS）为引发剂与丙烯酸共聚。用分散聚合法得到了含羧基（-COOH）的具有核壳结构的磁性高分子微球。并讨论了影响微球粒径的各种因素。同时采用SEM、IR等对样品进行了表征。相关文献 主题相关2、 CNKI数据库检索式：篇名=高分子*主题=磁性*主题=微球*主题=制备输出结果11、药物载体磁性高分子微球的制备及应用研究进展宋佳;朱春山;张强;邱莉;, 辽宁化工, 2010,(08), 820-823介绍了药物载体磁性高分子微球的研究现状,总结了常用的制备方法及应用进展,展望了磁性高分子微球的发展前景。12、反相悬浮法制备磁性高分子微球的研究李春蛟;林志勇;钱浩;, 化学工程与装备, 2010,(08), 30-33+15本文采用反相悬浮法,通过聚乙二醇的缩醛化反应,制备了具有灵敏磁响应性、表面富含羟基的微米级的磁性高分子微球。主要探讨了反应时间、聚乙烯醇浓度、搅拌速度、戊二醛(GA)用量及磁流体用量的变化对磁性高分子微球制备及性质的影响,用红外(FTIR)、激光粒径分析仪、扫描电子显微镜(SEM)、振动样品磁强计(VSM)进行表征。结果表明,所制备磁球表面羟基含量高,分散性好,磁含量高,具有超顺磁性。13、生物高分子磁性微球的制备及靶向给药应用刘尚莲;崔晗;, 化工时刊, 2010,(07), 34-38生物高分子磁性微球因具有磁效应、生物相容性和多种反应活性功能基团等特性,使其能广泛应用于生物医学、细胞学和生物工程等领域。综述了近年来生物高分子磁性微球的制备方法以及作为靶向给药载体的应用。14、磁性高分子微球及其在食品工业中的应用张铭明;冯志彪;, 农产品加工(学刊), 2009,(08), 4-7+10磁性高分子微球是指通过适当的方法使有机高分子与无机磁性物质结合起来形成的具有一定磁性及特殊结构的微球。与传统的固定化技术相比,磁性高分子微球易于修饰、分离,目前主要应用在生物医学和生物工程学领域。重点介绍磁性高分子微球在食品工业中的应用,介绍了磁性高分子微球的制备、性质和表面修饰方法。15、磁性高分子微球的研究进展及生物医学应用胡建;杨春雁;邱广亮;邱广明;, 内蒙古石油化工, 2009,(12), 3-5磁性高分子微球由于具有磁性和功能性基团,在许多领域尤其是细胞生物学、生物医学等领域具有广阔的应用前景。本文综述了磁性高分子微球的制备及生物医学应用等方面的研究进展。篇名=高分子*主题=磁性*关键词=微球*关键词=制备输出结果16、药物载体磁性高分子微球的制备及应用研究进展宋佳;朱春山;张强;邱莉;, 辽宁化工, 2010,(08), 820-823介绍了药物载体磁性高分子微球的研究现状,总结了常用的制备方法及应用进展,展望了磁性高分子微球的发展前景。17、反相悬浮法制备磁性高分子微球的研究李春蛟;林志勇;钱浩;, 化学工程与装备, 2010,(08), 30-33+15本文采用反相悬浮法,通过聚乙二醇的缩醛化反应,制备了具有灵敏磁响应性、表面富含羟基的微米级的磁性高分子微球。主要探讨了反应时间、聚乙烯醇浓度、搅拌速度、戊二醛(GA)用量及磁流体用量的变化对磁性高分子微球制备及性质的影响,用红外(FTIR)、激光粒径分析仪、扫描电子显微镜(SEM)、振动样品磁强计(VSM)进行表征。结果表明,所制备磁球表面羟基含量高,分散性好,磁含量高,具有超顺磁性。18、生物高分子磁性微球的制备及靶向给药应用刘尚莲;崔晗;, 化工时刊, 2010,(07), 34-38生物高分子磁性微球因具有磁效应、生物相容性和多种反应活性功能基团等特性,使其能广泛应用于生物医学、细胞学和生物工程等领域。综述了近年来生物高分子磁性微球的制备方法以及作为靶向给药载体的应用。19、磁性高分子微球及其在食品工业中的应用张铭明;冯志彪;, 农产品加工(学刊), 2009,(08), 4-7+10磁性高分子微球是指通过适当的方法使有机高分子与无机磁性物质结合起来形成的具有一定磁性及特殊结构的微球。与传统的固定化技术相比,磁性高分子微球易于修饰、分离,目前主要应用在生物医学和生物工程学领域。重点介绍磁性高分子微球在食品工业中的应用,介绍了磁性高分子微球的制备、性质和表面修饰方法。20、磁性高分子微球的研究进展及生物医学应用胡建;杨春雁;邱广亮;邱广明;, 内蒙古石油化工, 2009,(12), 3-5磁性高分子微球由于具有磁性和功能性基团,在许多领域尤其是细胞生物学、生物医学等领域具有广阔的应用前景。本文综述了磁性高分子微球的制备及生物医学应用等方面的研究进展。3、国家知识产权数据库检索式：名称=高分子and摘要=磁性微球输出结果21、名 称： 胺基聚丙烯酰胺磁性高分子微球制备方法 公 开 (公告) 号： CN1290721 申请(专利权)人： 哈尔滨工程大学 摘要 本发明公开了一种以超顺磁性的磁性流体为核，外包一层胺基聚丙烯酰胺高分子聚合物的磁性微球的制备方法。其主要工艺流程磁流体制备、引发剂吸附、反应单体分散和聚合、磁性微球磁分离和洗涤等。该微球悬浮性好，磁响应性高，粒径均匀。该磁性微球可作为各种酶、抗体、靶向药物的载体，广泛用于细胞分离、免疫分析、基因工程、酿酒发酵等众多领域。该制备方法简单，成本低，易于控制，微球质量好。 22、名 称： 具有光导性的磁性高分子微球及制备方法. 公 开 (公告) 号： CN1345885 申请(专利权)人： 中国科学院成都有机化学研究所 摘要 本发明涉及了一类新型兼具光导性、磁性和高分子微粒子特性的磁性微球及制备方法。它可以在外加磁场作用下快速移动，从而可以实现快速分离和纯化；因粒子表面键接有具有光导性的材料，且该材料具有可进一步反应的官能团，可以实现与抗原(抗体)或生物活性分子的结合，如应用于临床检测诊断领域，可望依赖光导性作为信号来获取生物活性分子间相互作用信息，从而为临床检测诊断领域提供一种新的方法。 23、名 称： 一种生物多糖高分子磁性微球及制备方法 公 开 (公告) 号： CN1600800 申请(专利权)人： 西北师范大学 摘要 本发明以罗望子胶、沙蒿胶、黄原胶、瓜尔豆胶等生物多糖高分子为制备材料，Fe3O4为磁流体，甲醛为交联剂，用对氨基苯磺酸磺酰化多糖羟基，制备了具有较高磁响应性的磁性微球。磁性微球呈表面多孔蜂窝状结构，粒径为2.0102-6.3102m，磁化率为1.393-1.726emu/g，表面功能基为-OSO2(C6H4)NH2。该类磁性微球，无毒、生物相容性好，操作性能和反应性能良好，可作为酶或其它生物材料的良好载体应用于不同领域。 24、名 称： 复乳法制备磁性高分子微球 公 开 (公告) 号： CN1616524 申请(专利权)人： 中国科学院过程工程研究所 摘要 本发明提供一种新型的磁性高分子微球的制备方法。该方法采用复乳化法制备磁性高分子微球，微球所包埋的磁性颗粒占整个微球的质量比为1-50，化学性质稳定，耐酸碱。其主要工艺流程为两种初乳液的制备、初乳液的混合、复乳化、溶剂去除、磁性微球的洗涤等。其特征在于不需事先制备磁性颗粒或高分子微球，可边使磁性颗粒生成边使其包埋在高分子微球内。微球粒径可由复乳化时外水相转速和外水相稳定剂含量来控制，磁含量可由内水相中溶质的浓度和内水相与油相的比例来控制。该磁性微球可作为酶、抗体、药物的载体，用于细胞分离、临床诊断、靶向药物载体、固定化酶、亲和分离等。本发明具有方法简单、重复性好、成本低、微球粒径可控、磁含量可控等特点。 25、名 称： 复乳法（W1/O/W2型）制备磁性高分子微球 公 开 (公告) 号： CN1834120 申请(专利权)人： 中国科学院过程工程研究所 摘要 本发明提供一种新型的磁性高分子微球的制备方法。这种方法使用复乳法制备磁性高分子微球，制备的磁性高分子微球粒径范围为50nm800m。微球所包埋的磁性颗粒占整个微球的质量比为0.550。其主要工艺流程为初乳乳液的制备、复乳化、碱的加入、有机溶剂的去除和复乳液滴的固化、磁性微球的洗涤和分离、微球干燥等。其特征在于先用复乳法制备内部包埋铁盐溶液的复乳乳液，然后再加入有机碱或无机碱使铁盐转化为磁性颗粒，再将复乳乳滴固化，制备出磁性高分子微球。微球粒径可由初乳乳液的黏度、复乳化时外水相的转速和外水相稳定剂的浓度来控制，磁含量可由内水相中溶质的浓度和内水相体积与油相体积的比例来控制。该磁性微球可作为各种酶、抗体、靶向药物的载体，广泛用于细胞分离、临床诊断、靶向药物载体、固定化酶、亲和分离等领域。本发明具有方法简单、重复性好、原料易得、成本低、微球粒径可控、微球磁含量均一、微球磁含量可控等特点。 外文数据库1、 SCI数据库检索式:主题=（polymer or macromolecule or high polymer）AND主题=（magnetic or magnetism）AND主题=（microspheres or microballon）AND主题=（preparation or manufacture）26、作者: Sun, L (Sun, Lei); Yu, XF (Yu, Xiaofang); Sun, MD (Sun, Mingda); Wang, HG (Wang, Hengguo); Xu, SF (Xu, Shufei); Dixon, JD (Dixon, John D.); Wang, YA (Wang, Y. Andrew); Li, YX (Li, Yaoxian); Yang, QB (Yang, Qingbiao); Xu, XY (Xu, Xiaoyi) 标题: Preparation of quantum dots encoded microspheres by electrospray for the detection of biomolecules 编码微球的制备方法,通过电喷雾量子点的检测生物分子来源出版物: JOURNAL OF COLLOID AND INTERFACE SCIENCE, 358 (1): 73-80 JUN 1 2011 摘要: In this paper, a novel method based on the electrospray technique has been developed for preparation of quantum dot (QD)-encoded microspheres for the fist time. By electrospraying the mixture of polymer solution and quantum dots solution (single-color QDs or multi-color QDs), it is accessible to obtain a series of composite microspheres containing the functional nanoparticle. Poly(styrene-acrylate) was utilized as the electrospray polymer materials in order to obtain the microsphere modified with carboxyl group on the surface. Moreover, to test the performance of the QD-encoded microsphere in bioapplication, it is carried out that immunofluorescence analysis between antigens of mouse IgG immobilized on the functional microsphere and FITC labeled antibodies of goat-anti-mouse IgG in experiment. To the best of our knowledge, this is the first report of QD-encoded microspheres prepared by electrospray technology. This technology can carry out the one-pot preparation of different color QD-encoded microspheres with multiple intensities. This technology could be also suitable for encapsulating other optical nanocrystals and magnetic nanoparticles for obtaining multifunctional microspheres. All of the results in this paper show that the fluorescence beads made by electrospray technique can be well applied in multiplex analysis. These works provide a good foundation to accelerate application of preparing microspheres by electrospray technique in practice. (c) 2011 Elsevier Inc. All rights reserved. DOI: 10.1016/j.jcis.2011.02.047 27、作者: Huang, L (Huang Lei); Xiong, ZY (Xiong Zhouyi); He, PS (He Pingsheng); Xiong, HG (Xiong Hanguo) 标题: PREPARATION AND ADSORPTION CHARACTERISTICS OF MAGNETIC MOLECULARLY IMPRINTED POLYMER MICROSPHERES 来源出版物: ACTA POLYMERICA SINICA, (1): 120-124 JAN 20 2011 摘要: Sulfanilamide magnetic molecularly imprinted polymer was prepared by using sulfanilamide as template molecule, methacrylic acid (MAA) as functional monomer and Fe3O4 magnetic fluid. The Fe3O4 magnetic fluid was successful preparedly by chemical co-precipitation method. The recognition mechanism of polymer was studied by UV spectrophotometry. The adsorption properties and selectivity ability were analyzed by Scatchard analysis and the equilibrium rebinding experiments. The results clearly exhibit that the synthesized magnetic molecularly-imprinted polymers have high sulfanilamide binding ability. Scatchard linear regression analysis indicated that the apparent maximum binding capacity (Q(max) was 280. 99 mu mol/g and the dissociation contents (K-D) of Sulfanilamide magnetic microsphere was 1.58 x 10(-3) mol/L. DOI: 10.3724/SP.J.1105.2011.10085 28、作者: Song, T (Song, Tao); Zhang, Q (Zhang, Qi); Lu, CL (Lu, Chaoliang); Gong, XQ (Gong, Xiaoqun); Yang, QH (Yang, Qiuhua); Li, YH (Li, Yunhong); Liu, JQ (Liu, Junqing); Chang, J (Chang, Jin) 标题: Structural design and preparation of high-performance QD-encoded polymer beads for suspension arrays 结构设计和制备高性能聚合物QD-encoded珠为悬浮阵列来源出版物: JOURNAL OF MATERIALS CHEMISTRY, 21 (7): 2169-2177 2011 摘要: Fluorescence-encoded polymer bead-based suspension arrays are widely used in biomolecular screening and diagnostic applications. The interior structure of polymer beads, especially the pore size, plays an important role in the preparation of fluorescent beads with a large encoding capacity and stability. Here, highly cross-linked carboxylated poly(styrene-co-ethylene glycol dimethacrylate-co-methacrylic acid) beads (PSEMBs) with optimum pore sizes were designed, fabricated, and further employed in the preparation of high-performance QD-encoded microbeads via a gradual solvent evaporation method. The PSEMBs and QD-encoded PSEMBs were characterized by scanning electron microscopy (SEM), laser scanning confocal microscopy, and spectrofluorometry. The SEM images and flow cytometry results of PSEMBs demonstrate the good sphericity and uniform particle size distribution. Confocal microscope images illustrate that highly uniform, bright fluorescent beads are obtained and the quantum dots (QDs) have filtrated into the entire microspheres, with the required pore size achieved by adjusting the content of porogen. Furthermore, QD-encoded PSEMBs were found to be photostable without leakage of QDs, and to retain their bright fluorescence for at least 20 days. Immunoassay performances for human IgG detections indicate that carboxyl groups on the fluorescent microsphere surface facilitate efficient attachment of biomacromolecules, and therefore enable high detection sensitivity (0.01 ng mL(-1) in sandwich immunoreactions. These results indicate that designed optical encoding microcarriers can be successfully applied to high-throughput and multiplexed biomolecular assays. Moreover, the new porous PSEMBs designed and fabricated in this report can efficiently load other nanoparticles (e.g. magnetic nanoparticles, Au and Ag nanoparticles) for a wide range of applications. DOI: 10.1039/c0jm02447c 29、作者: Zhang, XJ (Zhang, Xiaojuan); Jiang, W (Jiang, Wei); Ye, YF (Ye, Yuanfeng); Feng, ZQ (Feng, Zhiqiang); Sun, ZD (Sun, Zhendong); Li, FS (Li, Fengsheng); Hao, LY (Hao, Lingyun); Chu, JJ (Chu, Jianjun) 标题: A facile method to synthesize magnetic polymer nanospheres with multifunctional groups 一个很肤浅的方法合成纳米磁性高分子来了多功能组来源出版物: JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 323 (11): 1440-1444 JUN 2011 摘要: Magnetic poly(styrene methyl methacrylate)/Fe3O4 nanospheres with ester groups were prepared by a modified one-step mini-emulsion polymerization in the presence of Fe3O4 ferrofluids. The effects of monomer dose, surfactant content, ferrofluid concentration and initiator content on the particle characteristics such as the size, morphology and magnetic properties were investigated by Fourier-transform infrared spectroscopy, transmission electron microscopy, thermogravimetric analysis and vibrating sample magnetometer. The results indicated that magnetic nanospheres were superparamagnetic with high saturation magnetization of 51.0 emu/g and corresponding magnetite content of 61.5 wt%. Subsequently, magnetic nanospheres with carboxyl and amino groups were also obtained by hydrolysis and ammonolysis reaction. These magnetic nanospheres with multifunctional groups have biomedical applications. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved. DOI: 10.1016/j.jmmm.2010.12.033 30、作者: Niu, M (Niu Mu); Du, MH (Du Mei-Hong); Deng, Y (Deng Yi); Gao, MY (Gao Ming-Yuan) 标题: Preparation and Application in Capturing Bacteria of Submicron Immunomagnetic Beads 来源出版物: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 32 (2): 322-326 FEB 10 2011 摘要: Based on the submicron monodispersed magnetic beads, the immunomagnetic beads covered with anti-Salmonella antibody were obtained. The adsorption behavior of IgG on the surface of magnetic beads was investigated through surface electric potential, fluorescence and enzyme-linked immunosorbent assay (ELISA) method. In the immunoassay experiment, by adjusting the initial concentration of IgG, the relativity between surface concentration of IgG on magnetic beads and magnetic capture efficiency was also investigated. Finally, comparison with commercial Dynabeads, the submicron immunomagnetic beads represents higher capture efficiency for Salmonella 主题=（polymer or macromolecule or high polymer）AND标题=（magnetic or magnetism）AND标题=（microspheres or microballon）AND标题=（preparation or manufacture） 31、作者: Yang, WH (Yang Weihai); Wu, Y (Wu Yao); Zhang, Y (Zhang Yi); Wei, C (Wei Chen); Yan, SL (Yan Shoulei); Wang, QZ (Wang Qingzhang) 标题: Preparation and Application of Core-Shell Magnetic Molecularly Imprinted Polymer Microspheres 制备和应用的分子印迹聚合物微球具有核壳结构的磁性来源出版物: PROGRESS IN CHEMISTRY, 22 (9): 1819-1825 SEP 2010 摘要: Molecular imprinting technology is a borderline subject newly developed from combining high polymer chemistry, biochemistry, etc. Molecularly imprinted polymer prepared by molecular imprinting technology is a new polymer material with many advantages, such as excellent selectivity, high adsorption, high efficiency in chromatography and easy design. It is being increasingly used for several high technology fields, for instance, solid-phase extraction, chromatographic separation, bio- and chemo-sensors, targeted drug delivery, catalysis, immunoassays and artificial enzyme, etc. As a kind of novel functional materials, magnetic polymer microspheres developed in recent years have been widely used in the collection or separation of bioactive substances, targeted drug delivery, and diseases diagnoses or therapy. The core-shell magnetic molecular imprinted polymer microspheres prepared by surface molecularly imprinting on magnetism particles have combined the advantages of both molecularly imprinted polymer and magnetic polymer microspheres, especially good superparamagnetism and high selective adsorption. This review focuses on the preparation, structure and properties of core-shell magnetic molecularly imprinted polymer microspheres, as well as their application in chemical analysis, biological separation, and targeted drug delivery in recent years. The problems and challenges that still should be resolved are pointed out and the development tendency in these researches is discussed. 32、作者: Ai, FR (Ai Fan-Rong); Yao, AH (Yao Ai-Hua); Huang, WH (Huang Wen-Hai); Wang, DP (Wang De-Ping) 标题: Preparation and Characterization of Composite Microspheres with Magnetic and Temperature Dual Stimuli-responsive Properties 复合微球的制备与特性研究与磁场和温度双Stimuli-responsive性质来源出版物: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 31 (9): 1701-1705 SEP 10 2010 摘要: Oleic acid-coated Fe3O4 nanoparticles were synthesized by partial reduction coprecipitation method. Magnetic and temperature dual responsive composite microspheres, consisting of superparamagnetic Fe3O4 nanopaticles and thermoresponsive poly(N-isopropylacrylamide-acrylamide) microgel, were prepared by emulsion-free copolymerization. TEM, FTIR and XRD measurements were performed to characterize the structure and morphol