眼底外科.doc

姓名张少冲年龄43学科、专业眼科学眼底外科NameZhang ShaochongDate of birth1963.10MajorOphthalmology/fundus disease职称教授传真02087330384联系电话02087330415Current positionProfessorFax02087330384Tel02087330415电子邮件ZE-mailZ一、 申请导师简介（中英文，500字以内）Introduction of supervisor(in both Chinese and English; aximum 500words)（包括研究方向及专业特长等Please include the field of research and speciality.）主要从事玻璃体视网膜疾病方面的临床、科研和教学工作。有多年玻璃体视网膜和黄斑部疾病的诊疗经验及丰富研究积累，在国内一级核心期刊发表第一作者学术论文数十篇。在临床上对黄斑疾病如黄斑前膜、黄斑裂孔及视网膜脱离、增殖性玻璃体视网膜病变和晚期糖尿病视网膜病变的手术处理及技巧上有深入的研究；手术技巧熟练，对各种难度较高病例的手术处理均可收到良好的治疗效果；近年来在对较复杂性视网膜视网膜脱离及晚期黄斑孔的手术治疗方面提出较多新的观点并进行了相应的临床试验研究，取得了好的效果。在国内眼科学界，尤其在眼底病的诊断治疗及学术研究方面享有较高的声誉和较大的影响力。在科研上主要致力于增殖性玻璃体视网膜病变的研究，进行了增殖膜的体外培养、膜组织成分分析鉴定进而进行其形成机制方面的一系列动物试验和体外试验研究，进行了该疾病的多种药物的抑制试验，为临床药物联合手术治疗该疾病提供一定的理论依据和临床经验。1. I engages in retina and vitreous diseases, including scientific research and teachering works , We endeavour to retina- vitreous and macula diseases. I have published many research papers as the first author in the domestic core periodical. We make intensive studies of operation and macular hole, macular membrance , retina detachment; PVR and PDR . 2. In research work we devote ourselves to the pathogenesy and biotherapy of proliferative vitreoretinopathy, which including animal experiments and external experiments cultivation on preretinal membrance, and analyses tissue component and so on. To provide theory basis and clinical experiences for many clinic drugs combine operation diseases. 二、招收博士后拟承担或开展的主要研究任务（中英文）main task for post-doctorate research(in both Chinese and English)所招收的博士后主要进行眼底病专业的科学研究，具体科研方向以增殖性玻璃体视网膜病变的发病机制及生物治疗为主。从RPE细胞发生结构变化时细胞内RhoA激酶信号途径着手，寻找其发生的分子机制来着手研究PVR。在分子水平上研究PVR发生中RPE细胞基因及功能学的改变，并通过多种生化研究其在RPE细胞过渡增殖中的作用，深入研究RPE细胞中的信号转导途径，更进一步阐明PVR的发生发展机制。并通过构建PVR的动物模型，来研究PVR所致牵拉性视网膜脱离的有效防治方法。The research will mainly focus on the molecular mechanism of proliferative vitreoretinopathy by using checkpoints of RhoA kinase signaling pathway to control the migration and proliferation of RPE cells. Results will be expected to offer new insights on the changes of RPE gene expression and cell function in PVR patients at molecular level. At the same tim