免疫药物学博士.doc

张 彩 教授免疫药物学博士、硕士研究生导师，医学博士。1965年10月出生。1987年7月山东医科大学医学系毕业（本科，学士），1997-2000年山东医科大学（免疫学硕士），2001-2004年山东大学医学院（免疫学博士），2005年12月-2007年12月山东大学药学院（博士后）。2002年12月起为山东省医学科学院基础医学研究所研究员，2008年3月起为山东大学药学院免疫药理与免疫治疗研究所教授。电话传真-mail：学术兼职：中国免疫学会肿瘤免疫与生物治疗分会委员；山东免疫学会常务理事，山东免疫学会肿瘤免疫与肿瘤生物治疗专业委员会副主任委员；国家科学技术奖评审专家；863科技计划生物与医药技术领域网评专家；生物化学与生物物理研究进展、癌症、中国肿瘤生物治疗杂志审稿专家。研究方向：天然免疫识别与免疫药理学1. NK细胞受体及其配体的表达调控和信号通路；2. 基于RNA干扰技术的核苷酸类药物的设计和筛选；3. CD1d抗原递呈和NKT细胞Th1/Th2类细胞因子分泌的分子机制及新型糖脂类免疫增强剂的开发近五年承担的科研项目：1 国家自然科学基金重大研究计划：以荧光标记的小分子糖脂探针探讨CD1d抗原递呈和NKT细胞Th1/Th2类细胞因子分泌的分子机制，2008-20102 国家重点基础研究计划项目：“免疫系统起源的亿年超前追溯”子课题：“免疫球蛋白超家族分子、免疫细胞信号转导与死亡受体分子、天然免疫识别分子的起源及其信号转导系统研究”，2007-20123 “艾滋病和病毒性肝炎等重大传染病防治” 科技重大专项“十一五”课题：基于免疫学的抗乙肝病毒免疫治疗研究，2008-20104 国家自然科学基金：免疫干扰素对NKG2受体系统的负调节效应及其免疫学意义，2004-2006，已完成。 5 中国博士后基金（一等）和山东省博士后科研项目择优资助项目：干扰素和干扰素对肿瘤NKG2D配体的相反作用及其天然免疫逃逸价值，2006-2007，已完成。6 山东省优秀中青年科学家科研奖励基金：NKG2D配基在肿瘤的表达、调控及其天然免疫逃逸价值，2005-2007，已完成。近五年发表的代表性论文：1. Zhang C, Wang Y, Zhou Z, Zhang J, Tian Z. Sodium butyrate upregulates expression of NKG2D ligand MICA/B in HeLa and HepG2 cell lines and increases their susceptibility to NK lysis. Cancer Immunol Immunother, 2009, 2009;58:1275-1285.2. Zhang C, Niu J, Zhang J, Wang Y, Zhou Z, Zhang J, Tian Z. Opposing Effect of IFNa and IFNg on Expression of MHC class I chain-related A in Tumors. Cancer Science, 2008;99(6):1279-1286. 3. Zhang C, Zhang J, Niu J, Zhou Z, Zhang J, Tian Z. Interleukin-12 Improves Cytotoxicity of Natural Killer Cells via Upregulated Expression of NKG2D. Human Immunology, 2008;69(8):490-500. 4. Zhang C, Zhang J, Niu J, Zhang J, Tian Z. Interleukin-15 improves cytotoxicity of natural killer cells via up-regulating NKG2D and cytotoxic effector molecule expression as well as STAT1 and ERK1/2 phosphorylation. Cytokine, 2008;42(1):128-136. 5. Shang P, Zhang C, Xia C, Chen W, Han Q, Wang PG, Zhang J, Tian Z. Chemical Modification of iGb3 Increases IFN- Production by Hepatic NKT Cells. International Immunopharmacology, 2008;8(5):645-653. corresponding author6. Zhang C, Zhang J, Wei H, Sun R, Tian Z. Opposing effect of IFNg and IFNa on expression of NKG2 receptors: negative regulation of IFNg on NK cells. International Immunopharmacology, 2005;5(6):1057-1067. 7. Zhang C, Zhang J, Wei H, Tian Z. Imbalance of NKG2D and its inhibitory counterparts: how does tumor escape from innate immunity? International Immunopharmacology, 2005; 5(7-8):1099-111. 8. Dong Z, Zhang C, Wei H, Sun R, Tian Z. Impaired NK cell cytotoxicity by high level of interferon gamma in concanavalin A-induced hepatitis. Canadian Journal of Physiology and Pharmacology, 2005,83(11):1045-1053 co-first author9. Zhang C, Jian Zhang, Zhigang Tian. The regulatory effect of natural killer cells: do “NK-reg cells” exist? Cellular & Molecular Immunology, 2006;3(4):241-254.10. 张彩，田志刚. 天然免疫识别机制及其天然免疫受体的相互调节（特约述评）. 生物化学与生物物理进展，2008;35(2):124-128. Professor Zhang CaiBasic Information：Name: Cai Zhang Birthday: 09.10.1965Sex: femaleEducation Background: Ph.DTechnical Title: ProfessorMajor: ImmunopharmacologyTele:Fax-mail：2005-2007 School of pharmacy, Shandong University, Postdoctor20012004 School of Medicine, Shandong University, Ph.D in Immunology 19972000 Shandong Medical University, Master in Immunology19821987 Shandong Medical University, Bachelor in Clinical MedicineResearch Interests：Innate immune recognition and Immunopharmacology1. The expression machanisms and signal pathway of NK cell receptors and their ligands;2. The design and screening of RNA drugs based on RNA interence;3. The molecular mechanisms of antigen presenting by CD1d and secretion of Th1/Th2 cytokines by NKT cells;4. The exploration of new types of immuno-stimulatory drugs based on glycolipids.Projects：1. “Exploration on molecular mechanisms of antigen presenting by CD1d and secretion of Th1/Th2 cytokines by NKT cells by using fluorescence-lablelled glycolipid probes” supported by grants from the Natural Science Foundation of China (No.90713033), 2008-20102. “The trace on immune system evolution for hundreds million years” supported by grants from the Major State Basic Research Development Program of China (973 Program) (No.2007CB815800), 2007-20123. “The negative regulation of Interferon gamma on NKG2 system and its significance” supported by grants from the Natural Science Foundation of China (No.30371302), 2004-20064. “Opposing effect of IFNgamma and IFNalpha on expression of NKG2D ligands and the significance in tumor escape from innate immunity” supported by grants from the Postdoctoral Foundation of China and Shandong Province, 2006-20075. “The expression and regulation mechanisms of NKG2D ligands and the significance in tumor escape from innate immunity” supported by grants from the Foundation for excellent young scientists of Shandong Province, 2005-2007Publications1. Zhang C, Niu J, Zhang J, Wang Y, Zhou Z, Zhang J, Tian Z. Opposing Effect of IFNa and IFNg on Expression of MHC class I chain-related A in Tumors. Cancer Science, 2008;99(6):1279-1286.2. Zhang C, Zhang J, Niu J, Zhou Z, Zhang J, Tian Z. Interleukin-12 Improves Cytotoxicity of Natural Killer Cells via Upregulated Expression of NKG2D. Human Immunology, 2008;69(8):490-500.3. Zhang C, Zhang J, Niu J, Zhang J, Tian Z. Interleukin-15 improves cytotoxicity of natural killer cells via up-regulating NKG2D and cytotoxic effector molecule expression as well as STAT1 and ERK1/2 phosphorylation. Cytokine, 2008;42(1):128-136. 4. Shang P, Zhang C, Xia C, Chen W, Han Q, Wang PG, Zhang J, Tian Z. Chemical Modification of iGb3 Increases IFN- Production by Hepatic NKT Cells. International Immunopharmacology, 2008;8(5):645-653. corresponding author5. Zhang C, Wang Y, Zhou Z, Zhang J, Tian Z. Sodium butyrate upregulates expression of NKG2D ligand MICA/B in HeLa and HepG2 cell lines and increases their susceptibility to NK lysis. Cancer Immunol Immunother, 2009, 2009;58:1275-1285. 6. Zhang C, Zhang J, Wei H, Sun R, Tian Z. Opposing effect of IFNg and IFNa on expression of NKG2 receptors: negative regulation of IFNg on NK cells. International Immunopharmacology, 2005;5(6):1057-1067.7. Zhang C, Zhang J, We