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122.11 2.222.332.442.517%533.14.271. .j.2007.91014392. .j.2007,7117783. .j.200828(2):224. .j.2008,1342375. .2010.11:2457,.2009;(8):571-572. metapubmed8% 13.7%11: ; ; ; 2h2metapubmed1. rctrctrcth22. metametametaz = 6.79p 0.00001or = 7.8995% ci ( 4.3514.33)meta: 5 ; 1 ; 6 1 1meta3. 34. pubmedpubmed.5.pubmed1rct1160 80 45 35 40 29 4 7 16 41 3 +18+3 40 35 9 46 34 39 28 4 914 42 3 +19 +3 41 38 7 23-p0.054rct5. meta12cochrane lirarypubmed325 3325 282 ( ) 37 6 6: ( ) ; 4 5 ; 56( p = 0.94i2 = 0%) meta z = 6.79p 0.00001or =7.8995% ci ( 4.3514.33) 76. metameta 1.metarctmeta,metameta7. rctmeta8. 1 , . meta j. , 2012, 21(6): 528-5322 j 200828( 3) : 167-1683 , . j. , 2013, 30(2): 143-1462012 apr;107(4):507-20; quiz 521. doi: 10.1038/ajg.2011.474. epub 2012 jan 31.proton pump inhibitors vs. histamine 2 receptor antagonists for stress-related mucosal bleeding prophylaxis in critically ill patients: a meta-analysis. 1, , , .abstractobjectives:h2-receptor antagonists (h2ra) have been shown to reduce stress-related mucosal bleeding (srmb), yet randomized controlled trials assessing proton pump inhibitors (ppis) have yielded conflicting results. the objective of this study was to evaluate the efficacy of ppis vs. h2ras in the prophylaxis of srmb in critically ill adults with risk factors for bleeding.methods:conclusions:2013 mar;48(3):285-94. doi: 10.3109/00365521.2012.758764. epub 2013 jan 8. 100021.5?12?1234a41()()12?iso690iso690-2.a. .().1 .m.1957.15-18.2 .ac.1994.3 .d.1983.4 .lbbr.1997.b. .j.().5 .j.1998(3)167-173.6 .j.()199333(4)62-67.c. .a.().c.7 .a.c.1996.468-471.d. .n.().8 .n.1998-12-25(10).e. s.9 gb/t1615