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一、英文文献:biofluid + bile (主题)以及 Biological fluid + bile (主题) (2013年1月13日)1 ) Application of Ultra Performance Liquid Chromatography-Mass Spectrometry to Profiling Rat and Dog Bile 作者: Plumb, RS (Plumb, Robert S.)2; Rainville, PD (Rainville, Paul D.)2; Potts, WB (Potts, Warren B., III)2; Johnson, KA (Johnson, Kelly A.)2; Gika, E (Gika, Eleni)1; Wilson, ID (Wilson, Ian D.)1 来源出版物: JOURNAL OF PROTEOME RESEARCH 卷: 8 期: 5 页: 2495-2500 DOI: 10.1021/pr801078a 出版年: MAY 20092 ) Comprehensive proteomic analysis of human bile作者: Barbhuiya, Mustafa A.; Sahasrabuddhe, Nandini A.; Pinto, Sneha M.; 等.来源出版物: PROTEOMICS 卷: 11 期: 23 页: 4443-4453 DOI: 10.1002/pmic.201100197 出版年: DEC 20113 ) Phase behavior and rheological properties of lecithin/TTAOH/H2O mixtures作者: Zhou, Xiangzhu; Dong, Shuli; Hao, Jingcheng来源出版物: COLLOID AND POLYMER SCIENCE 卷: 289 期: 13 页: 1451-1457 DOI: 10.1007/s00396-011-2468-y 出版年: AUG 20114 ) Statistical and Fractal Processing of Phase Images of Human Biological Fluids作者: Ushenko, Yuriy; Tomka, Yuriy; Marchuk, Yuriy; 等.来源出版物: ADVANCES IN ELECTRICAL AND COMPUTER ENGINEERING 卷: 10 期: 4 页: 161-166 DOI: 10.4316/AECE.2010.04026 出版年: 20105 ) A simulation of oral absorption using classical nucleation theory作者: Sugano, Kiyohiko来源出版物: INTERNATIONAL JOURNAL OF PHARMACEUTICS 卷: 378 期: 1-2 页: 142-145 DOI: 10.1016/j.ijpharm.2009.05.056 出版年: AUG 13 20096 ) Proteomic analysis of human bile and potential applications for cancer diagnosis作者: Farina, Annarita; Dumonceau, Jean-Marc; Lescuyer, Pierre来源出版物: EXPERT REVIEW OF PROTEOMICS 卷: 6 期: 3 页: 285-301 DOI: 10.1586/EPR.09.12 出版年: JUN 20097 ) Non-newtonian bile flow in elastic cystic duct: One- and three-dimensional modeling作者: Li, W. G.; Luo, X. Y.; Chin, S. B.; 等.来源出版物: ANNALS OF BIOMEDICAL ENGINEERING 卷: 36 期: 11 页: 1893-1908 DOI: 10.1007/s10439-008-9563-3 出版年: NOV 20088 ) One-step analysis of major bile components in human bile using H-1 NMR spectroscopy作者: Gowda, G. A. Nagana; Somashekar, B. S.; Ijare, Omkar B.; 等.来源出版物: LIPIDS 卷: 41 期: 6 页: 577-589 出版年: JUN 20069 ) Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability/bioequivalence studies作者: Kalantzi, L; Goumas, K; Kalioras, V; 等.来源出版物: PHARMACEUTICAL RESEARCH 卷: 23 期: 1 页: 165-176 DOI: 10.1007/s11095-005-8476-1 出版年: JAN 200610) Uranium(VI) solubility and speciation in simulated elemental human biological fluids作者: Sutton, M; Burastero, SR来源出版物: CHEMICAL RESEARCH IN TOXICOLOGY 卷: 17 期: 11 页: 1468-1480 DOI: 10.1021/tx049878k 出版年: NOV 200411) Development of an in vitro digestion model for estimating the bioaccessibility of soil contaminants作者: Oomen, AG; Rompelberg, CJM; Bruil, MA; 等.来源出版物: ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY 卷: 44 期: 3 页: 281-287 DOI: 10.1007/s00244-002-1278-0 出版年: APR 200312) Lead speciation in artificial human digestive fluid作者: Oomen, AG; Tolls, J; Sips, AJAM; 等.来源出版物: ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY 卷: 44 期: 1 页: 107-115 DOI: 10.1007/s00244-002-1225-0 出版年: JAN 200313) Analysis of the optical properties of bile.作者: Baldini, F; Bechi, P; Cianchi, F; 等.来源出版物: Journal of biomedical optics 卷: 5 期: 3 页: 321-9 DOI: 10.1117/1.430003 出版年: 2000-Jul14) Gas chromatography of bile acids.作者: Batta, A K; Salen, G来源出版物: Journal of chromatography. B, Biomedical sciences and applications 卷: 723 期: 1-2 页: 1-16 DOI: 10.1016/S0378-4347(98)00528-3 出版年: 1999-Feb-1915) Separation techniques for bile salts analysis.作者: Roda, A; Piazza, F; Baraldini, M来源出版物: Journal of chromatography. B, Biomedical sciences and applications 卷: 717 期: 1-2 页: 263-78 DOI: 10.1016/S0378-4347(98)00174-1 出版年: 1998-Oct-916) Cholesterol carriers in human bile: are lamellae involved?作者: Cohen, D E; Kaler, E W; Carey, M C来源出版物: Hepatology (Baltimore, Md.) 卷: 18 期: 6 页: 1522-31 DOI: 10.1016/0270-9139(93)90247-K 出版年: 1993-Dec17) Protein inhibitors of calcium salt crystal growth in saliva, bile and pancreatic juice.作者: Verdier, J M; Dussol, B; Berland, Y; 等.来源出版物: Scanning microscopy 卷: 7 期: 3 页: 1017-30 出版年: 1993-Sep18) Comparative study of methods for measuring cholesterol in biological fluids.作者: Cheillan, F; Lafont, H; Termine, E; 等.来源出版物: Lipids 卷: 24 期: 3 页: 224-8 DOI: 10.1007/BF02535239 出版年: 1989-Mar19) Phospholipid peroxidation as a factor in gallstone pathogenesis.作者: Lichtenberg, D; Ragimova, S; Peled, Y; 等.来源出版物: FEBS letters 卷: 228 期: 1 页: 179-81 DOI: 10.1016/0014-5793(88)80612-4 出版年: 1988-Feb-820) Mechanisms of hepatic bile formation.作者: Forker, E L来源出版物: Annual review of physiology 卷: 39 页: 323-47 DOI: 10.1146/annurev.ph.39.030177.001543 出版年: 197721) A model for gallbladder function and cholesterol gallstone formation. 作者: Cussler, E L; Evans, D F; DePalma, R G来源出版物: Proceedings of the National Academy of Sciences of the United States of America 卷: 67 期: 1 页: 400-7 DOI: 10.1073/pnas.67.1.400 出版年: 1970-Sep 摘要: An analysis of fluid mechanics and diffusion in the gallbladder predicts that there is a thin layer of high bile-constituent concentration near the gallbladder wall. Cholesterol may precipitate in this layer, even when the average cholesterol concentration in the gallbladder is below saturation. The amount precipitated increases with time, with increased average cholesterol concentration, and with decreased average lecithin concentration. If the gallbladder does not empty completely, the precipitated cholesterol particles may grow over many cycles of gall bladder filling and emptying. The analysis explains why cholesterol-gallstone formation is not correlated with bile-constituent concentration alone, why a flaccid, noncontractile, gallbladder has a greater chance of forming gallstones, why small stones are frequently found near the gallbladder wall, and why stones may be found in only one limb of a double gallbladder. 二、Bile + properties + gallstone(主题:98); Bile + properties + gall stone (5)22) Mucin and phospholipids determine viscosity of gallbladder bile in patients with gallstones作者: Jungst, D; Niemeyer, A; Muller, I; 等.来源出版物: WORLD JOURNAL OF GASTROENTEROLOGY 卷: 7 期: 2 页: 203-207 出版年: APR 200123) Formation of gall stones; physical properties of bile salts. 作者: RAINS, A J; CRAWFORD, N来源出版物: Nature 卷: 171 期: 4358 页: 829-31 DOI: 10.1038/171829b0 出版年: 1953-May-924) Involvement of osteopontin as a core protein in cholesterol gallstone formation 作者: Ichikawa, H (Ichikawa, Hideaki)1; Imano, M (Imano, Motohiro)1; Takeyama, Y (Takeyama, Yoshifumi)1; Shiozaki, H (Shiozaki, Hitoshi)1; Ohyanagi, H (Ohyanagi, Harumasa)1 来源出版物: JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY 卷: 16 期: 2 页: 197-203 DOI: 10.1007/s00534-009-0043-4 出版年: MAR 2009 25) A new physicochemical characterization of sodium taurodeoxycholate/water system 作者: Youssry, M (Youssry, Mohamed)1; Coppola, L (Coppola, Luigi)1; Furia, E (Furia, Emilia)1; Oliviero, C (Oliviero, Cesare)1; Nicotera, I (Nicotera, Isabella)1 来源出版物: PHYSICAL CHEMISTRY CHEMICAL PHYSICS 卷: 10 期: 45 页: 6880-6889 DOI: 10.1039/b809582e 出版年: 2008 26) Biliary bacterial factors determine the path of gallstone formation 作者: Stewart, L (Stewart, Lygia); Grifiss, JM (Grifiss, J. McLeod); Jarvis, GA (Jarvis, Gary A.); Way, LW (Way, Lawrence W.) 来源出版物: AMERICAN JOURNAL OF SURGERY 卷: 192 期: 5 页: 598-603 DOI: 10.1016/j.amjsurg.2006.08.001 出版年: NOV 2006 Conclusions: Bacterial properties determined the path of gallstone formation. Bacteria that produced all stone-forming factors promoted pigment stone formation, while those that produced only bGPhL promoted mixed stone formation. Bacteria that only produced slime lacked the ability to generate pigment solids, and consequently were more common in the centers of cholesterol stones. This shows how bacterial characteristics may govern the process of gallstone formation27) Use of novel cationic bile salts in cholesterol crystallization and solubilization in vitro 作者: Bhat, S (Bhat, Shreedhar); Leikin-Gobbi, D (Leikin-Gobbi, Diana); Konikoff, FM (Konikoff, Fred M.); Maitra, U (Maitra, Uday) 来源出版物: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 卷: 1760 期: 10 页: 1489-1496 DOI: 10.1016/j.bbagen.2006.06.013 出版年: OCT 2006 28) Formation of cholesterol crystals at a mucin coated substrate 作者: Liao, XM (Liao, Xiangmin); Wiedmann, TS (Wiedmann, Timothy S.) 来源出版物: PHARMACEUTICAL RESEARCH 卷: 23 期: 10 页: 2413-2416 DOI: 10.1007/s11095-006-9004-7 出版年: OCT 200629) Stability of patient bile and study on its influential factors 作者: Shen, YH (Shen, YH); Huang, FZ (Huang, FZ); Xie, AJ (Xie, AJ); Xiong, QR (Xiong, QR); Chen, KB (Chen, KB) SPECTROSCOPY AND SPECTRAL ANALYSIS 卷: 25 期: 10 页: 1648-1651 出版年: OCT 2005 语种: Chinese30) Influence of H+ on the aggregation properties of sodium deoxycholate aqueous solution 作者: Zhang, L (Zhang, L); Yang, ZL (Yang, ZL); Xiong, Y (Xiong, Y); Peng, TT (Peng, TT); Weng, SF (Weng, SF); Wu, JG (Wu, JG) 来源出版物: ACTA PHYSICO-CHIMICA SINICA 卷: 20 期: 10 页: 1196-1199 出版年: OCT 2004 语种: Chinese31) Physico-chemical properties of gallstones 作者: Nusier, M (Nusier, M); Shawakfeh, K (Shawakfeh, K); Otoom, S (Otoom, S) 来源出版物: ASIAN JOURNAL OF CHEMISTRY 卷: 16 期: 1 页: 213-219 出版年: JAN-MAR 2004 32) Influence of divalent metal ions on the aggregation properties of EYPC 作者: Yu, KB (Yu, KB); Yang, ZL (Yang, ZL); Zhang, L (Zhang, L); Wang, F (Wang, F); Weng, SF (Weng, SF); Wu, JG (Wu, JG) 出版物: ACTA PHYSICO-CHIMICA SINICA 卷: 19 期: 8 页: 747-750 出版年: AUG 2003 语种: Chinese33) Study on the relationship between the gallstone formation and the properties of patient bile 作者: Xie, AJ (Xie, AJ); Shen, YH (Shen, YH); Huang, FZ (Huang, FZ) 来源出版物: JOURNAL OF INORGANIC BIOCHEMISTRY 卷: 96 期: 1 页: 252-252 DOI: 10.1016/S0162-0134(03)80806-1 出版年: JUL 15 2003 34) Measurement of cholesterol gallstone growth in vitro. 作者: van Den Berg, A A; van Buul, J D; Ostrow, J D; Groen, A K来源出版物: Journal of lipid research 卷: 41 期: 2 页: 189-94 出版年: 2000-Feb35) A recombinant bovine gallbladder mucin polypeptide binds biliary lipids and accelerates cholesterol crystal appearance time. 作者: Nunes, D P; Afdhal, N H; Offner, G D出版物: Gastroenterology 卷: 116 期: 4 页: 936-42 DOI: 10.1016/S0016-5085(99)70077-6 出版年: 1999-Apr36) Anionic polypeptide fraction in bile of patients with and without gallstones. 作者: Domingo, N; Lafont, H; Halpern, Z; Peled, Y; Grosclaude, J; Gilat, T来源出版物: Hepatology (Baltimore, Md.) 卷: 17 期: 5 页: 778-80 DOI: 10.1016/0270-9139(93)90151-C 出版年: 1993-May 37) Surface chemistry of phospholipid vesicles relevant to their aggregation and fusion. 作者: MacDonald, R C来源出版物: Hepatology (Baltimore, Md.) 卷: 12 期: 3 Pt 2 页: 56S-60S 出版年: 1990-Sep 摘要: A general description of those forces that are important in the stability of the lipid bilayer is presented. The analysis focuses on those that may change under conditions in which aggregation or fusion of vesicles or exchange of their molecules may occur. It is that class of membrane forces that is most likely to play a role in the process(es) that leads to the formation of cholesterol crystals in bile, which eventually grow into gallstones. A specific, hypothetical mechanism for cholesterol crystal nucleation based on vesicle fusion is also given. This mechanism is consistent with the principles of surface chemistry outlined. 38) Cholesterol packing, crystallization and exchange properties in phosphatidylcholine vesicle systems. 作者: Phillips, M C出版物: Hepatology (Baltimore, Md.) 卷: 12 期: 3 Pt 2 页: 75S-80S; discussion 80S-82S 出版年: 1990-Sep 摘要: The properties of phosphatidylcholine/cholesterol vesicles have been studied extensively because of their relevance to the behavior of these components in cell membranes. At equilibrium, phosphatidylcholine bilayers are saturated when equimolar levels of cholesterol are incorporated; the cholesterol molecules interfere with the cooperative lateral interactions of the phosphatidylcholine acyl chains and restrict the fluidity relative to pure liquid-crystal phosphatidylcholine bilayers. Mixed cholesterol/phosphatidylcholine bilayers containing more than equimolar cholesterol are metastable; on storage excess cholesterol is released from the vesicles and forms cholesterol monohydrate crystals. This process models the formation of cholesterol gallstones in bile and the growth of the crystals probably involves, at least in part, diffusion of cholesterol molecules from the vesicle bilayer to the crystal surface. The cholesterol-phosphatidylcholine interaction energy in the lipid-water interface of the donor vesicle has a critical effect on the rate of this transfer process. 39) Principles of laser light-scattering spectroscopy: applications to the physicochemical study of model and native biles. 作者: Cohen, D E; Fisch, M R; Carey, M C出版物: Hepatology (Baltimore, Md.) 卷: 12 期: 3 Pt 2 页: 113S-121S; discussion 121S-122S, 1990-Sep 摘要: We present a nonmathematical treatment of the theoretical and experimental aspects of modern laser light-scattering techniques. We also describe the design of a home-built laser light-scattering apparatus used in the authors laboratory for the physicochemical study of model and native biles. These powerful techniques provide nonperturbing measurements of the sizes, polydispersities and, in suitable cases, concentrations and shapes of simple micelles, mixed micelles, vesicles and large proteins in bile. the sizes of these aggregates (10 to 2,000 A) fall within limits resolvable by laser light and are conventionally expressed as mean hydrodynamic radii, Rh. Static light-scattering measurements of biliary lipid aggregates provide molecular weights and important information concerning particle shape, whereas quasielastic (also referred to as dynamic) light-scattering measurements assess particle sizes and polydispersities. Under favorable circumstances, quasielastic light scattering allows simultaneous determinations of sizes and concentrations of coexisting particle populations. The use of laser light-scattering technology in solving the solution properties and the physicochemical structures of model and native biles is detailed. In view of the extraordinarily diverse backgrounds of researchers in the gallstone field (e.g., internists, surgeons, biochemists, physicists), we believe that the present article (which relies heavily on graphical representations) will afford a better understanding of the usefulness and limitations of laser light-scattering techniques, particularly in their applications to the study of bile. 40) Effects of somatostatin on hepatic bile formation. 作者: Magnusson, I; Einarsson, K; Angelin, B; Nyberg, B; Bergstrom, K; Thulin, L来源出版物: Gastroenterology 卷: 96 期: 1 页: 206-12 出版年: 1989-Jan 摘要: Somatostatin is a peptide that has anticholeretic properties in the dog. The purpose of the present work was to investigate if somatostatin is an anticholeretic agent in humans also. The effects of intravenous infusion of somatostatin on hepatic bile flow and biliary electrolytes and secretion of biliary lipids were studied in 7 patients with complete biliary drainage who had been operated on for choledocholithiasis. Somatostatin, 250 microgram/h, was found to decrease the hepatic bile secretion by approximately 30%. The peptide also reduced the outputs of bile acids, cholesterol, and phospholipids and the outputs of sodium, potassium, and chloride. The concentrations of the biliary lipids were not significantly changed. Somatostatin inhibited the erythritol clearance in the 2 patients studied by approximately 25%. The present study thus provides evidence that somatostatin inhibits bile formation in humans. It appears as if the reduction in bile production is mainly due to decreased canalicular bile flow. It is possible that this effect of somatostatin is attributable to inhibition of bile acid synthesis or of transport-secretion of bile acids, or both. 41) Thermodynamic and molecular basis for dissimilar cholesterol-solubilizing capacities by micellar solutions of bile salts: cases of sodium chenodeoxycholate and sodium ursodeoxycholate and their glycine and taurine conjugates. 作者: Carey, M C; Montet, J C; Phillips, M C; Armstrong, M J; Mazer, N A来源出版物: Biochemistry 卷: 20 期: 12 页: 3637-48 DOI: 10.1021/bi00515a052 出版年: 1981-Jun-9 摘要: The bile salts chenodeoxycholate (CDC) and its 7 beta-hydroxy epimer ursodeoxycholate (UDC) are administered therapeutically (as acids) to dissolve cholesterol gallstones in man. Since their micellarr solutions and those of their physiological conjugates differ strikingly in their capacities to solubilize cholesterol, we studied the interfacial and micellar properties of the epimers by a number of complimentary physical-chemical methods and correlated these with their solubilizing capacities. The critical micella concentrations (cmc) estimated by surface tension, dye titration, and turbidimetry were similar (1-5 mM), varying slightly with the bile salt species, the method employed, NaCl concentration (0-1 M), and temperature (10-50 degrees C). The weight-average aggregation number (number of monomers per micelle, nw) at the cmc, derived from Debye plots of conventional light-scattering data and from the mean hydrodynamic radii of the micelles obtained by quasi-elastic light-scattering spectroscopy, revealed no appreciable differences between the UDC-CDC epimers or between their conjugates. From the mean hydrodynamic radii, the taurine conjugates were found to form larger micelles (nw = 15-17) than the glycine conjugates (nw = 13) which in turn were larger than the free species (n w = 5), respectively. Consistent with previous experimental deductions, free and conjugated CDC micelles grew slightly in size with increases in total lipid concentration, but UDC mice

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