拉米夫定抗乙肝病毒感染治疗的数学模型及疗效预测.pdf

1 100083 jyslt bjliweidong lqmin Nowak HBV HBV HBV HBV 1 1 20 6 9 75 28 3 5 1 2 10 2 HBV 3 CHB interferon lamivudine adefovir 4 712 HBeAg CHB HBV DNA HBV DNA 1996 Nowak 3 HBV 5 HBV 1 Nos 60074034 70271068 No 20020008004 1 Nowak 6 HBV HBV HBV HBV HBV 2 HBeAg CHB 2005 6 New England J Med 712 HBeAg CHB 4 2 336 336 504 HBV DNA HBV DNA Nowak 5 CHB CHB HBV dx dt dx b k0 vx dy dt b k0 vx a k1 y pye dv dt k k2 y u k3 v k6e de dt k4y k5e 1 HBV dx dt dx bvx dy dt bvx ay pye dv dt ky uv k6e de dt k5e 2 x y v e dx b ay ky uv k4y k is p 3 1 48 2 48 HBV DNA HBV DNA 1 2 d b a p k u k0 k1 k2 k3 k4 k5 k6 2 4e 5 3 6e 3 1 3313e 12 3 6e 3 6e 15 5 4082e 1 4e 1 0 1 3313e 12 0 54 078 0 12 5e 3 1 6e 2 9e 13 d b a k u 2 4e 5 3 6e 3 1 3313e 12 3 6e 3 5 4082e 1 4e 1 2 0285684126168210252294336364420504 10 1 10 2 10 3 10 4 10 5 10 6 10 7 10 8 10 9 10 10 10 11 Plasma virus HBV DNA copies ml Time Weeks Treatment Follow up Treatment Follow up 1 336 168 HBV DNA CHB HBV DNA 0285684126168210252294336364420504 10 1 10 2 10 3 10 4 10 5 10 6 10 7 10 8 10 9 10 10 10 11 Plasma virus HBV DNA copies ml Time Weeks Treatment Follow up 2 336 168 HBV DNA 504 CHB HBV DNA HBeAg CHB HBV DNA 2 HBV DNA 336 2 5322 103 ml 504 HBV DNA 1 22 103 ml HBV DNA 7 92 104 ml 4 HBV HBV Nowak HBV 3 3 HBV HBV HBV HBV 1 Maddrey W C Hepatitis B an important public health issue Clin Lab 47 51 59 2001 2 10 2005 9 15 3 2003 12 15 htpp disparticle asp classid 3 id 15 4 George K K Lau M D Teerha Piratvisuth M D et al Peginterferon Alfa 2a Lamivudine and the Combination for HBeAg Positive Chronic Hepatitis B New England Journal of Medicine 352 26 2682 2695 2005 5 Nowak M J Bonhoeff er S Hill A M et al Viral dynamics in hepatitis B virus infection Proc Natl Acad Sci USA 93 4398 402 1996 6 Lequan Min Xisong Dong Research on viral dynamic models of