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一、翻译(共20分,每题1分)。1 Hexane2 Mercury3 Potassium4 Cysteine 5 Methionine6 Amide7 Ethyl acetate8 Potassium carbonate9 Sodium bicarbonate10 Pentane11 苏氨酸12 腺苷酸13 氯14 碘 15 脯氨酸16 色氨酸 17 酮18 环己烷19 CaCO320 氯化钠 答案:1 己烷2 汞3 钾4 半胱氨酸5 甲硫氨酸6 酰胺7 乙酸乙酯8 碳酸钾9 碳酸氢钠10 戊烷11 Threonine12 Adenylic acid13 Chlorine14 Iodine15 Proline16 Tryptophan17 Acetone18 Cyclohexane19 Calcium carbonate20 Sodium chloride二、写出下列缩写的英文全称并翻译(共10分,每题2分)。1 QSAR: 2 TLC: 3 UV/visible: 4 MBA: 5 CEO: 答案:1 Quantitative Structure-Activity Relationship 定量构效关系2 Thin Layer Chromatography 薄层层析法3 Ultraviolet-visible spectroscopy 紫外分光光度法4 Master (Management) of Business Administration 工商管理硕士5 Chief Executive Officer 首席执行官三、判断(共16分,每题2分),并用 表示。1 ( )Analytical chemists work to improve the reliability of existing techniques to meet the demands for better chemical measurements which arise constantly in our society.2 ( )A specific reaction or test is one that occur only with the substance of interest.3 ( )The lead compound is not intended to be used as a clinical agent.4 ( )Biomolecules are compounds of carbon.5 ( )Highly polar water-soluble drugs being transferred slowly whereas highly lipidsoluble, non-polar drugs are transferred rapidly across the lipid-rich membranes of cells.6 ( )The degree of aqueous solubility of the drug affects the rate of the dissolution.7 ( )Direct comparison with authentic (if available) should not be carried out as final confirmation.8 ( )Lead compounds can be obtained from a variety of different sources such as the flora and fauna of the natural world, or synthetic compounds made in the laboratory. There is also the potential of designing lead compounds using computer modeling or NMR spectroscopic studies.答案: 1 2 3 4 5 6 7 8 四、单选题(共14分,每题2分)。1 Quantitative analysis D with the determination of how much of one or more constituents is present.A do B research C seek D deal2 Presently, D , it is applied in a very general manner to synthetic as well as to natural compounds in the search for new lead compound.A UV B NMR C IR D HTS3 alcohols have one or more C groups A acetyl B aldehyde C hydroxyl D carboxyl4 C view of the complexity of the human body, it is inevitable that pharmacokinetic formulations must be based on drastically simplifying assumptions.A In B At C By D As5 A the temperature is maintained at a constant 37 , and the agitation of stirring rate is held to a specified constant. A In vivo B In vitro C In aqueous solution D In vacuum6 In UV A of the material are required, since the standard spectrophotometric cell only hold 3 mL of solution and, using special cells, only one tenth of this volume need be available for spectrophotometry.A only traces B many C little D much7 In the UK, only drug products and biological manufacturers (not A ; except some specified antibiotics) were inspected by the regulatory authority for compliance to GMP.A APIs B drug C manufacturers D OTCs答案: 1 D 2 D 3 C 4 C 5 A 6 A 7 A五、英译汉(共20分,每题5分)。1 The four most abundant elements in living organisms, in terms of the percentage of the total number of atoms, are hydrogen, oxygen, nitrogen, and carbon, which together make up over 99% of the mass of most cells.答案: 四种含量最丰富的元素在生物体中的原子总数的百分比计算,是氢,氧,氮,碳,加起来超过全部细胞总重的99。2 A one-compartment model with first-order elimination often approximates the clinical situation surprisingly well once absorption and distribution have occurred.答案:当吸收分布过程完成后,一个遵循一级消除的一室模型与临床情况十分相似。3 Analytical chemists work to improve the reliability of existing techniques to meet the demands for better chemical measurements which arise constantly in our society.答案: 分析化学家的工作是改善现有技术的可靠性,以更好的化学检测方法满足我们社会不断的需求。4 Solid drug products exempted from disintegration tests include troches, tablets which are intended to be chewed, and drug products intended for sustained release or prolonged or repeat action.答案: 免除崩解测试的固体药品包括含片、咀嚼片和缓控释释放、长效释放、重复释放制剂。六、问答题(共20分,每题5分)。1 According to the Noyes-Whitney equation, what may be influence the dissolution kinetics?答案: It can be seen from the Noyes-Whitney equation that dissolution kinetics may be influenced by the physicochemical characteristics of the drug, the formulation, and the solvent.2 If authentic material is not available, what should to be done for its identification?答案: Careful comparison with literature data many suffice for its identification.3 What is the selective reaction or test?答案: A selective reaction or test is one that can occur with other substances
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