流行病学文献评价.doc

精品 文献评价报告学生姓名：* 班级: * 学号：* 本科专业：* 现攻读专业：*导师： * 评价论文题目：Association between low-dose folic acid supplementation and blood lipids concentrations in male and female subjects with atherosclerosis risk factors.出处： Med Sci Monit. 2013; 19: 733739.设计类型: DRUG CONTROLLED STUDIES药物对照研究 论文性质：预防1.选题是否具有科学性与创新性?文章的提出有科学性，有创新性，可行性，与临床密切相关However, the preventive effect of FA on cardiovascular disease remains unclear. Large-scale clinical trials failed to show a benefit from Hcy-lowering treatment in individuals with established cardiovascular disease or with history of myocardial infarction. However, those studies evaluated high-dose FA supplementation as secondary prevention and were not investigating low-dose FA supplementation as primary prevention of cardiovascular disease .2.研究目的是否明确? 是，明确。The aim of this study was to analyze the association of low-dose folic acid supplementation with blood lipids concentrations in subjects with atherosclerosis risk factors.3.设计方案是否作了优选? 研究对象是否明确?样本数量是否作了估算?类型：药物对照（自身前后对照），临床试验性研究样本选择：Initially, FA supplementation was offered to 147 subjects, 23 of whom (15.6%) were excluded in the course of the study due to non-compliance (irregular taking of FA, stopping it altogether, or not reporting for the follow-up examination at the end of the treatment period).未做样本含量估算。The study enrolled 124 Caucasian individuals (60 M, ages 2039; and 64 F, ages 1939) with atherosclerosis risk factors (family history of premature ischemic stroke, arterial hypertension, dyslipidemia, overweight and obesity, cigarette smoking, and low level of physical activity). 样本选取合适4.诊断标准/纳入标准/排除标准是否明确?衡量指标是否恰当?所用名词定义明确，诊断指标，测量方法，结局指标清晰，可靠性高5.研究或试验流程是否明确?有无质量控制措施？共5个表，结果清晰，资料详尽，内部符合性高6.统计方法是否正确?采用统计方法合理，按男女分层分析，再按不同危险因素分析，控制和调整了混杂因素7.对该论文的总体感受如何？设计清晰，数据清晰，指标明确，有创新，贴近临床版面清晰In view of our results, it seems that low-dose FA supplementation, used as primary prevention, has a beneficial effect on blood lipids through decreasing concentrations of total cholesterol and LDL and increasing concentrations of apoAI. To determine the value of FA in