微管相关蛋白TAU与ALZHEIMER病神经原纤维退变

Alzheimer AD NFT NFT tau tau PHF NFT AD AD AD tau tau tau 2 3 AD tau tau 5 9 1 1M 1mol L AD tau tau 2 tau PHF PHF tau 21 PHF tau tau 3 AD tau tau AD tau 4 5 4 AD tau 1 tau C tau 2 tau AD P tau 3 PHF tau PHF tau 1 PHF tau 2 SDS PHF tau PHF tau AD tau tau C tau AD P tau PHF tau PHF tau 6 PHF tau AD tau Ca2 7 tau AD PP 2A PP 2B PP 1 8 PP 2A PP 2B tau 9 AD P tau PP 2A PP 2B PP 1 tau 57 36 30 10 PP 2A AD P tau Km 8 0 2 8 mol L 8 PP 2A PP 2B PHF tau AD P tau 7 Yamamoto 11 PHF tau PP 2A PP 2B PP 1 tau PHF NFT tau AD tau empirenews page PP 2A PP 2B AD tau Mn2 Mg2 7 Mn2 Ca2 PP 2B tau AD tau tau 1 2 AD tau PP 2A PP 2B PP 1 AD P tau Wang PP 2A AD P tau PP 2B PP 1 9 PP 2A PP 2B PHF tau PP 2A PHF tau PP 2B 7 tau tau 4 tau PHF NFT PHF 22 24 nm 80 nm 10 nm PHF PHF AD PHF NFT PP 2A PP 2A PHF NFT PP 2A PHF NFT tau 7 F N F AD P tau PHF NFT tau 4 2 5 0 5 nm tau PHF NFT PP 2A PHF NFT tau PP 2A tau 4 7 tau PHF NFT PHF tau AD P tau 2 1 3 3 nm 12 PHF 4 AD P tau PHF tau AD P tau PHF PHF tau tau 1 PDPK X S T P X S T P 2 non PDPK 21 PHF tau PDPK non PDPK AD tau tau tau ManderKow tau ser 262 13 Singh ser 262 40 tau 14 tau ser 262 AD GSK 3 50 15 empirenews page AD tau tau AD PP 2A PP 2B PP 1 ADP tau PHF tau AD P tau 1 2 PHF tau PP 2A PP 2B PHF NFT PHF tau PHF NFT 2 5 0 5 nm tau AD P tau AD P tau PHF tau PHF tau