兽医药理学皮质激素系统药理

江苏农牧科技职业学院,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,外,用,醋酸肤轻松,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,肾上腺皮质激素的基本结构为甾核，构效关系非常密切： C3的酮基、C20的羰基及C4-5的双键是保持生理功能所必需； 糖皮质激素的C17上有-OH；C11上有=O或-OH； 盐皮质激素的C17上无-OH；C11上无=O或有O与C18相联； C1-2为双键（泼尼松、氢化泼尼松）以及C6引入-CH3（甲氢强的松）则抗炎作用增强、水盐代谢作用减弱； C9引入-F（氢氟可的松），C16引入-CH3或-OH（去炎松）则抗炎作用更强、水盐代谢作用更弱。 21 C H2O H,20,18,C,17,O,16,15,R,11,1,2,3,10,9,8,12,13,C,A,4,5,D,14,B,6,7,O,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,HSP70R HSP90 IPIP,S,S,S,R,（不稳定）,IPIP,IPIP,S,R*,S,R*,激素-受体二聚体（激活）,DNA,GRE,S,CBG,生物效应,功能蛋白,mRNA 编辑,细胞浆,S,S,S,R*R*,pre-mRNA细胞核,）,转录复合体（RNA聚合酶等）,糖皮质激素（GCS）基本作用模式,CBG：皮质激素转运球蛋白；S：糖皮质激素 ；R：糖皮质激素受体；R*：激活的糖皮质激素受体； HSP：热休克蛋白；IP：免疫亲和素,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,下丘脑,长负反馈,CRF,+,垂体前叶,ACTH,短负反馈,+,肾上腺,糖皮质激素,外源性糖皮质激素,（抗炎、免疫抑制）,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,PDF created with pdfFactory Pro trial version ,PDF cre