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一 核酸及其相关数据库一 核酸及其相关数据库 1 1 核酸序列数据库核酸序列数据库 BIOSINOBIOSINO 我国的核酸序列公共数据库我国的核酸序列公共数据库 1 1 核酸序列数据库核酸序列数据库 BIOSINOBIOSINO 我国的核酸序列公共数据库我国的核酸序列公共数据库 EMBLEMBL EMBLEMBL NucleotideNucleotide sequencesequence databasedatabase EBI EBI GenBankGenBank GenBankGenBank NucleotideNucleotide SequenceSequence databasedatabase NCBI NCBI DDBJDDBJ DNADNA DataData BankBank ofof JapanJapan dbESTdbEST DatabaseDatabase ofof ExpressedExpressed SequenceSequence TagsTags NCBI NCBI dbSTSdbSTS DatabaseDatabase ofof SequenceSequence TaggedTagged SitesSites NCBI NCBI 2 2 基因组及相关数据库基因组及相关数据库 GenomicGenomic DatabasesDatabases GenomeWeb HGMP GenomeWeb HGMP A A cataloguecatalogue ofof usefuluseful WebWeb sitessites forfor GenomicsGenomics withwith a a setset ofof collectionscollections ofof genomegenome databasesdatabases GSDBGSDB GenomeGenome SequenceSequence databasedatabase NCGR NCGR GOLDGOLD GenomesGenomes On lineOn line dbdb 一些数据库的直接链接一些数据库的直接链接 DOGSDOGS DatabaseDatabase ofof GenomeGenome SizesSizes GenomicsGenomics webweb sitesite John John WileyWiley SonsSons Ltd Ltd The The GenomicsGenomics websitewebsite atat WileyWiley isis a a newnew andand DYNAMICDYNAMIC resourceresource forfor thethe genomicsgenomics community community offeringoffering FREEFREE specialspecial featurefeature articlesarticles andand newnew informationinformation EACHEACH MONTH MONTH HUGOHUGO HUmanHUman GenomeGenome OrganizationOrganization 3 3 核酸三维结构数据库核酸三维结构数据库 NDBNDB NucleicNucleic AcidAcid DatabankDatabank 3D 3D structures structures BNASDBBNASDB NucleicNucleic acidacid structurestructure dbdb fromfrom UniversityUniversity ofof PunePune 4 4 转基因数据库 转基因数据库 TransgenicsTransgenics CreCre TransgenicTransgenic DatabaseDatabase CreCre transgenictransgenic mousemouse lineslines Transgenic TargetedTransgenic Targeted MutationMutation DatabaseDatabase InformationInformation onon transgenictransgenic animalsanimals andand targetedtargeted mutationsmutations 5 5 其他其他 AsDbAsDb AberrantAberrant SplicingSplicing dbdb ACUTSACUTS AncientAncient conservedconserved untranslateduntranslated DNADNA sequencessequences dbdb CodonCodon UsageUsage DbDb TheThe frequencyfrequency ofof codoncodon useuse inin eacheach organismorganism isis mademade searchablesearchable throughthrough thisthis WorldWorld WideWide WebWeb site site EPDEPD EukaryoticEukaryotic PromoterPromoter dbdb HOVERGENHOVERGEN HomologousHomologous VertebrateVertebrate GenesGenes dbdb IMGTIMGT ImMunoGeneTicsImMunoGeneTics dbdb Mirror Mirror atat EBI EBI ISISISIS IntronIntron SequenceSequence andand InformationInformation SystemSystem RDPRDP RibosomalRibosomal dbdb ProjectProject gRNAsgRNAs dbdb GuideGuide RNARNA dbdb PLACEPLACE PlantPlant cis actingcis acting regulatoryregulatory DNADNA elementselements dbdb PlantCAREPlantCARE PlantPlant cis actingcis acting regulatoryregulatory DNADNA elementselements dbdb sRNAsRNA dbdb SmallSmall RNARNA dbdb ssussu rRNArRNA SmallSmall ribosomalribosomal subunitsubunit dbdb lsulsu rRNArRNA LargeLarge ribosomalribosomal subunitsubunit dbdb 5S5S rRNArRNA 5S5S ribosomalribosomal RNARNA dbdb tmRNAtmRNA WebsiteWebsite tmRDBtmRDB tmRNAtmRNA dBdB tRNAtRNA tRNAtRNA compilationcompilation fromfrom thethe UniversityUniversity ofof BayreuthBayreuth uRNADBuRNADB uRNAuRNA dbdb RNARNA editingediting RNARNA editingediting sitesite RNAmodRNAmod dbdb RNARNA modificationmodification dbdb TelDBTelDB MultimediaMultimedia TelomereTelomere ResourceResource TRADATTRADAT TRAnscriptionTRAnscription DatabasesDatabases andand AnalysisAnalysis ToolsTools SubviralSubviral RNARNA dbdb SmallSmall circularcircular RNAsRNAs dbdb viroid viroid andand viroid like viroid like MPDBMPDB MolecularMolecular probeprobe dbdb OPDOPD OligonucleotideOligonucleotide probeprobe dbdb VectorDBVectorDB VectorVector sequencesequence dbdb 二 基因表达数据库二 基因表达数据库 ASDBASDB ProteinProtein productsproducts andand expressionexpression patternspatterns ofof alternatively splicedalternatively spliced genesgenes AxeldbAxeldb GeneGene expressionexpression inin XenopusXenopus BodyMapBodyMap HumanHuman andand mousemouse genegene expressionexpression datadata EpoDBEpoDB GenesGenes expressedexpressed inin vertebratevertebrate RBCRBC FlyViewFlyView DrosophilaDrosophila developmentdevelopment andand geneticsgenetics GeneGene ExpressionExpression DatabaseDatabase GXD GXD MouseMouse genegene expressionexpression andand genomicsgenomics KidneyKidney DevelopmentDevelopment DatabaseDatabase KidneyKidney developmentdevelopment andand genegene expressionexpression MAGESTMAGEST AscidianAscidian Halocynthia Halocynthia roretzi roretzi genegene expressionexpression patternspatterns MouseMouse AtlasAtlas andand GeneGene ExpressionExpression DatabaseDatabase Spatially mappedSpatially mapped genegene expressionexpression datadata PEDBPEDB NormalNormal andand aberrantaberrant prostateprostate genegene expressionexpression ToothTooth DevelopmentDevelopment DatabaseDatabase GeneGene expressionexpression inin dentaldental tissuetissue TRIPLESTRIPLES TRansposon InsertionTRansposon Insertion Phenotypes Phenotypes LocalizationLocalization andand ExpressionExpression inin SaccharomycesSaccharomyces 三 蛋白质及其相关数据库三 蛋白质及其相关数据库 1 1 蛋白质序列和相关数据库蛋白质序列和相关数据库 SWISS PROTSWISS PROT SWISS PROTSWISS PROT annotatedannotated proteinprotein sequencesequence dbdb PIR internationalPIR international The The ProteinProtein InformationInformation ResourceResource protein protein sequence sequence MIPSMIPS MartinsriedMartinsried instituteinstitute forfor proteinprotein sequencesequence andand homologyhomology datadata andand yeastyeast genomegenome informationinformation PROSITEPROSITE PROSITEPROSITE dictionarydictionary ofof proteinprotein sitessites andand patternspatterns InterProInterPro IntegratedIntegrated ResourcesResources ofof ProteinsProteins DomainsDomains andand FunctionalFunctional SitesSites BLOCKSBLOCKS BLOCKSBLOCKS dbdb DOMODOMO ProteinProtein domaindomain dbdb Automatically Automatically generated generated PfamPfam ProteinProtein familiesfamilies dbdb HMM HMM derived derived Mirror Mirror atat Sanger Sanger PRINTSPRINTS ProteinProtein MotifMotif fingerprintfingerprint dbdb ProDomProDom ProteinProtein domaindomain dbdb Automatically Automatically generated generated PROTOMAPPROTOMAP AnAn automaticautomatic hierarchicalhierarchical classificationclassification ofof SWISS PROTSWISS PROT proteinsproteins SBASESBASE SBASESBASE domaindomain dbdb Protein Protein domaindomain sequencesequence library library SMARTSMART ProteinProtein signallingsignalling andand extracellularextracellular domaindomain patternspatterns Simple Simple ModularModular ArchitectureArchitecture ResearchResearch Tool Tool ProClassProClass ProteinProtein sequencesequence alignmentsalignments andand curationcuration ofof proteinprotein familiesfamilies KabatKabat KabatKabat dbdb ofof proteinprotein ofof immunologicalimmunological interestinterest PMDPMD ProteinProtein MutantMutant dbdb 2 2 蛋白质三维结构和相关数据库蛋白质三维结构和相关数据库 PDBPDB ProteinProtein DataData BankBank Mirrors Mirrors inin EBI EBI BioMagResBankBioMagResBank RepositoryRepository forfor datadata onon proteins proteins peptides peptides andand nucleicnucleic acidsacids fromfrom NMRNMR spectroscopyspectroscopy SWISS MODELSWISS MODEL RepositoryRepository AutomaticallyAutomatically generatedgenerated proteinprotein modelsmodels dbdb ModBaseModBase DbDb ofof comparativecomparative proteinprotein structurestructure modelsmodels CATHCATH UCLUCL BSMBSM structuralstructural classificationclassification ofof proteinsproteins SCOPSCOP StructuralStructural classificationclassification ofof proteinsproteins Mirror Mirror atat USAUSA IsraelIsrael SingaporeSingapore Australia Australia Mol R UsMol R Us MoleculesMolecules R R Us Us browserbrowser forfor PDBPDB BMMBMM DomainDomain ServerServer BiomolecularBiomolecular ModellingModelling LaboratoryLaboratory ICRF ICRF proteinprotein domaindomain serverserver PRESAGEPRESAGE CollaborativeCollaborative resourceresource forfor structuralstructural genomicsgenomics ReLiBaseReLiBase Receptor ligandReceptor ligand complexescomplexes dbdb Mirror Mirror inin USA USA TOPSTOPS ProteinProtein topologytopology atlasatlas CCDCCCDC CambridgeCambridge CrystallographicCrystallographic DataData CenterCenter Cambridge Cambridge StucturalStuctural DbDb CSD CSD HSSPHSSP Homology derivedHomology derived secondarysecondary structurestructure ofof proteinsproteins dbdb SWISS 3DIMAGESWISS 3DIMAGE 3D3D imagesimages ofof proteinsproteins andand otherother biologicalbiological macromoleculesmacromolecules BioImageBioImage BiologicalBiological imageimage dbdb contains contains imagingimaging datadata onon macromolecules macromolecules 3 3 蛋白质二维凝胶电泳数据库蛋白质二维凝胶电泳数据库 WORLD 2DPAGEWORLD 2DPAGE A A completecomplete indexindex ofof 2D PAGE2D PAGE dbdb andand serversservers PhoretixPhoretix linkslinks PhoretixPhoretix pagepage ofof linkslinks toto 2D2D gelgel dbdb 4 4 信号传导及蛋白质信号传导及蛋白质 蛋白质相互作用相关数据库蛋白质相互作用相关数据库 DIPDIP DbDb ofof InteractingInteracting ProteinsProteins INTERACTINTERACT Protein ProteinProtein Protein interactioninteraction dbdb ProNetProNet Protein ProteinProtein Protein interactioninteraction dbdb CANSITECANSITE SignalSignal Transduction sTransduction s WebWeb SPADSPAD SignalingSignaling pathwaypathway dbdb CSNDBCSNDB CellCell SignalingSignaling NetworksNetworks dbdb 5 DNA5 DNA 和蛋白质相互作用数据库和蛋白质相互作用数据库 DPInteractDPInteract DNA ProteinsDNA Proteins interactionsinteractions dbdb 五 糖类相关数据库五 糖类相关数据库 CarbBankCarbBank ComplexComplex CarbohydrateCarbohydrate StructureStructure DatabaseDatabase GlycoSuiteDBGlycoSuiteDB DbDb ofof glycanglycan structuresstructures TGNTGN TheThe GlycoscienceGlycoscience NetworkNetwork FCCAFCCA ForumForum CarbohydratesCarbohydrates ComingComing ofof AgeAge CARBHYDCARBHYD CarbohydrateCarbohydrate informationinformation WWWWWW sitessites MonosacharideMonosacharide browserbrowser SpaceSpace fillingfilling FischerFischer projectionprojection forfor monosaccharidesmonosaccharides 六六 蛋白质翻译后修饰相关数据库 蛋白质翻译后修饰相关数据库 O GlycBaseO GlycBase O glycosylatedO glycosylated proteinsproteins dbdb PhosphoBasePhosphoBase PhosphorylationPhosphorylation sitessites dbdb RESIDRESID DbDb ofof AminoAmino AcidAcid ModificationsModifications 七 人类基因突变及疾病相关数据库七 人类基因突变及疾病相关数据库 HMGDHMGD HumanHuman GeneGene MutationMutation dbdb SVDSVD SequenceSequence variationvariation dbdb HGBASEHGBASE HumanHuman GenicGenic Bi AllelicBi Allelic SequencesSequences dbdb TheThe SNPSNP consortiumconsortium dbSNPdbSNP HumanHuman singlesingle nucleotidenucleotide polymorphismpolymorphism SNP SNP dbdb ListList ofof mutationmutation databasesdatabases fromfrom OMIMOMIM ListList ofof mutationmutation databasesdatabases fromfrom IMTIMT Finland Finland ADBADB AlbinismAlbinism dbdb Mutations Mutations inin humanhuman genesgenes causingcausing albinism albinism Alpha glucosidaseAlpha glucosidase InformationInformation aboutabout humanhuman acidacid alpha glucosidasealpha glucosidase GSD II GSD II ARAR mutationsmutations HumanHuman androgenandrogen receptorreceptor mutationmutation dbdb AntithrombinAntithrombin mutationmutation dbdb AsthmaAsthma andand AllergyAllergy genegene dbdb BIOMDBBIOMDB DbDb ofof mutationsmutations causingcausing tetrahydrobiopterintetrahydrobiopterin deficienciesdeficiencies BLMbaseBLMbase HumanHuman BLMBLM mutationmutation dbdb Bloom Bloom snydrom snydrom BTKbaseBTKbase HumanHuman BTKBTK mutationmutation dbdb X linked X linked agammaglobulinemia agammaglobulinemia CD40LbaseCD40Lbase HumanHuman CD40CD40 ligandligand mutationmutation dbdb COL1 3COL1 3 mutationmutation HumanHuman TypeType I I andand IIIIII collagencollagen mutationmutation dbdb CFTRCFTR mutationmutation HumanHuman cysticcystic fibrosisfibrosis mutationmutation dbdb CFTR CFTR EMDEMD dbdb HumanHuman EmerinEmerin EMD EMD mutationmutation dbdb Emery Dreifuss Emery Dreifuss muscularmuscular dystrophy dystrophy KMeyeDBKMeyeDB EyeEye diseasedisease genesgenes dbdb FVIIFVII mutationmutation HumanHuman FactorFactor VIIVII mutationmutation dbdb HAMSTeRSHAMSTeRS HumanHuman FactorFactor VIIIVIII mutationmutation dbdb Haemophilia Haemophilia A A HAeMBHAeMB HumanHuman FactorFactor IXIX mutationmutation dbdb Haemophilia Haemophilia B B FBN1FBN1 mutationmutation HumanHuman fibrillinfibrillin 1 1 mutationmutation dbdb Marfan Marfan syndrome syndrome G6PDG6PD HumanHuman G6PDG6PD deficiencydeficiency resourceresource GaltGalt mutationmutation HumanHuman galactose 1 phosphategalactose 1 phosphate uridylyltransferaseuridylyltransferase mutationmutation dbdb Galactosemia Galactosemia HEXAdbHEXAdb HumanHuman HexosaminidaseHexosaminidase A A mutationmutation dbdb Tay sachs Tay sachs disease disease IL2RGbaseIL2RGbase HumanHuman IL2RGIL2RG Interleukin 2 Interleukin 2 receptorreceptor gamma gamma mutationmutation dbdb X SCID X SCID L1CAML1CAM mutationmutation HumanHuman L1CAML1CAM mutationmutation dbdb LDLRLDLR mutationmutation HumanHuman LDLRLDLR mutationmutation dbdb Familial Familial hypercholesterolemia hypercholesterolemia LQTSdbLQTSdb LongLong QTQT syndromesyndrome dbdb NCF1baseNCF1base HumanHuman NCF1NCF1 mutationmutation dbdb NCF2baseNCF2base HumanHuman NCF2NCF2 mutationmutation dbdb NeuromuscularNeuromuscular diseasesdiseases webweb sitesite NCLNCL NeuronalNeuronal CeroidCeroid LipofuscinosesLipofuscinoses mutationmutation dbdb OTCaseOTCase HumanHuman ornithineornithine transcarbamylasetranscarbamylase OTCase OTCase websitewebsite CytochromeCytochrome P450P450 allelesalleles nomenclaturenomenclature p53p53 mutationmutation dbdb UniversityUniversity ofof TokyoTokyo p53p53 mutationmutation dbdb GermlineGermline p53p53 mutationmutation dbdb UniversityUniversity ofof PraguePrague dbdb ofof germlinegermline p53p53 mutationsmutations PAHdbPAHdb HumanHuman phenylalaninephenylalanine hydroxylasehydroxylase PAH PAH mutationmutation dbdb PAX6PAX6 mutationmutation HumanHuman PAX6PAX6 mutationmutation dbdb PrionPrion PrionPrion andand prionprion diseasedisease webweb sitesite RAG1baseRAG1base HumanHuman RAG1RAG1 mutationmutation dbdb RAG2baseRAG2base HumanHuman RAG2RAG2 mutationmutation dbdb RB1baseRB1base HumanHuman retinoblastoma associatedretinoblastoma associated proteinprotein RB RB mutationmutation dbdb RetNetRetNet RetinalRetinal InformationInformation NetworkNetwork RetinaRetina InternationalInternational ScientificScientific NewsletterNewsletter InformationInformation onon RetinalRetinal genes genes proteinsproteins andand diseasesdiseases TSCTSC TSCTSC TSC1 TSC2 TSC1 TSC2 variationvariation dbdb TSC2TSC2 Cardiff RotterdamCardiff Rotterdam TuberousTuberous SclerosisSclerosis TS TS dbdb Tuberin Tuberin TSC2 TSC2 TGDBTGDB TumorTumor genegene dbdb
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