




已阅读5页,还剩51页未读, 继续免费阅读
版权说明:本文档由用户提供并上传,收益归属内容提供方,若内容存在侵权,请进行举报或认领
文档简介
Gene Expression Transcription Regulation,Dafna AradNoa Gordon20/5/02, Transcription Factors (TFs) Regulatory Motifs ., , , : cis / trans / on/off DNA , - RNA Pol ., , ? ? ? ?,Bucher P.:Regulatory elements and expression profilesCurr Opin Struct Biol 9 400-407, - . ., . , ., ,Bottom up ( ) ( )Top down . ( , ),Church GM: Computational Identification of Cis-regulatory Elements Associated with Groups of Functionally Related Genes in Saccharomyces cerevisiae J. Mol Biol 296 1205-1214, : AlignACE(Align nucleic Acid Conserved Elements) Gibbs Sampling algorithm,AlignACE, : . . . . .,AlignACE, , Regulon. : RNA - Clustering ,5- TCTCTCTCCACGGCTAATTAGGTGATCATGAAAAAATGAAAAATTCATGAGAAAAGAGTCAGACATCGAAACATACAT,5- ATGGCAGAATCACTTTAAAACGTGGCCCCACCCGCTGCACCCTGTGCATTTTGTACGTTACTGCGAAATGACTCAACG,5- CACATCCAACGAATCACCTCACCGTTATCGTGACTCACTTTCTTTCGCATCGCCGAAGTGCCATAAAAAATATTTTTT,5- TGCGAACAAAAGAGTCATTACAACGAGGAAATAGAAGAAAATGAAAAATTTTCGACAAAATGTATAGTCATTTCTATC,5- ACAAAGGTACCTTCCTGGCCAATCTCACAGATTTAATATAGTAAATTGTCATGCATATGACTCATCCCGAACATGAAA,5- ATTGATTGACTCATTTTCCTCTGACTACTACCAGTTCAAAATGTTAGAGAAAAATAGAAAAGCAGAAAAAATAAATAA,5- GGCGCCACAGTCCGCGTTTGGTTATCCGGCTGACTCATTCTGACTCTTTTTTGGAAAGTGTGGCATGTGCTTCACACA,AlignACE Example,300-600 bp of upstream sequence per gene are searched in Saccharomyces cerevisiae.,5- TCTCTCTCCACGGCTAATTAGGTGATCATGAAAAAATGAAAAATTCATGAGAAAAGAGTCAGACATCGAAACATACAT,5- ATGGCAGAATCACTTTAAAACGTGGCCCCACCCGCTGCACCCTGTGCATTTTGTACGTTACTGCGAAATGACTCAACG,5- CACATCCAACGAATCACCTCACCGTTATCGTGACTCACTTTCTTTCGCATCGCCGAAGTGCCATAAAAAATATTTTTT,5- TGCGAACAAAAGAGTCATTACAACGAGGAAATAGAAGAAAATGAAAAATTTTCGACAAAATGTATAGTCATTTCTATC,5- ACAAAGGTACCTTCCTGGCCAATCTCACAGATTTAATATAGTAAATTGTCATGCATATGACTCATCCCGAACATGAAA,5- ATTGATTGACTCATTTTCCTCTGACTACTACCAGTTCAAAATGTTAGAGAAAAATAGAAAAGCAGAAAAAATAAATAA,5- GGCGCCACAGTCCGCGTTTGGTTATCCGGCTGACTCATTCTGACTCTTTTTTGGAAAGTGTGGCATGTGCTTCACACA,AAAAGAGTCA,AAATGACTCA,AAGTGAGTCA,AAAAGAGTCA,GGATGAGTCA,AAATGAGTCA,GAATGAGTCA,AAAAGAGTCA,*, ,MAP score = 20.37 (maximum),HIS7,ARO4,ILV6,THR4,ARO1,HOM2,PRO3,5- TCTCTCTCCACGGCTAATTAGGTGATCATGAAAAAATGAAAAATTCATGAGAAAAGAGTCAGACATCGAAACATACAT,5- ATGGCAGAATCACTTTAAAACGTGGCCCCACCCGCTGCACCCTGTGCATTTTGTACGTTACTGCGAAATGACTCAACG,5- CACATCCAACGAATCACCTCACCGTTATCGTGACTCACTTTCTTTCGCATCGCCGAAGTGCCATAAAAAATATTTTTT,5- TGCGAACAAAAGAGTCATTACAACGAGGAAATAGAAGAAAATGAAAAATTTTCGACAAAATGTATAGTCATTTCTATC,5- ACAAAGGTACCTTCCTGGCCAATCTCACAGATTTAATATAGTAAATTGTCATGCATATGACTCATCCCGAACATGAAA,5- ATTGATTGACTCATTTTCCTCTGACTACTACCAGTTCAAAATGTTAGAGAAAAATAGAAAAGCAGAAAAAATAAATAA,*,TGAAAAATTC,GACATCGAAA,GCACTTCGGC,GAGTCATTAC,GTAAATTGTC,CCACAGTCCG,TGTGAAGCAC,5- TCTCTCTCCACGGCTAATTAGGTGATCATGAAAAAATGAAAAATTCATGAGAAAAGAGTCAGACATCGAAACATACAT,5- ATGGCAGAATCACTTTAAAACGTGGCCCCACCCGCTGCACCCTGTGCATTTTGTACGTTACTGCGAAATGACTCAACG,5- CACATCCAACGAATCACCTCACCGTTATCGTGACTCACTTTCTTTCGCATCGCCGAAGTGCCATAAAAAATATTTTTT,5- TGCGAACAAAAGAGTCATTACAACGAGGAAATAGAAGAAAATGAAAAATTTTCGACAAAATGTATAGTCATTTCTATC,5- GGCGCCACAGTCCGCGTTTGGTTATCCGGCTGACTCATTCTGACTCTTTTTTGGAAAGTGTGGCATGTGCTTCACACA,*,TGAAAAATTC,GACATCGAAA,GCACTTCGGC,GAGTCATTAC,GTAAATTGTC,CCACAGTCCG,TGTGAAGCAC,MAP score = -10.0,HIS7,ARO4,ILV6,THR4,ARO1,HOM2,PRO3,5- TCTCTCTCCACGGCTAATTAGGTGATCATGAAAAAATGAAAAATTCATGAGAAAAGAGTCAGACATCGAAACATACAT,5- ATGGCAGAATCACTTTAAAACGTGGCCCCACCCGCTGCACCCTGTGCATTTTGTACGTTACTGCGAAATGACTCAACG,5- CACATCCAACGAATCACCTCACCGTTATCGTGACTCACTTTCTTTCGCATCGCCGAAGTGCCATAAAAAATATTTTTT,5- TGCGAACAAAAGAGTCATTACAACGAGGAAATAGAAGAAAATGAAAAATTTTCGACAAAATGTATAGTCATTTCTATC,5- ACAAAGGTACCTTCCTGGCCAATCTCACAGATTTAATATAGTAAATTGTCATGCATATGACTCATCCCGAACATGAAA,5- ATTGATTGACTCATTTTCCTCTGACTACTACCAGTTCAAAATGTTAGAGAAAAATAGAAAAGCAGAAAAAATAAATAA,5- GGCGCCACAGTCCGCGTTTGGTTATCCGGCTGACTCATTCTGACTCTTTTTTGGAAAGTGTGGCATGTGCTTCACACA,*,sampling,TGAAAAATTC,GACATCGAAA,GCACTTCGGC,GAGTCATTAC,GTAAATTGTC,CCACAGTCCG,TGTGAAGCAC,Add?,*,TGAAAAATTC,GACATCGAAA,GCACTTCGGC,GAGTCATTAC,GTAAATTGTC,CCACAGTCCG,TGTGAAGCAC,TCTCTCTCCA,HIS7,ARO4,ILV6,THR4,ARO1,HOM2,PRO3, 2 -?alignments,5- TCTCTCTCCACGGCTAATTAGGTGATCATGAAAAAATGAAAAATTCATGAGAAAAGAGTCAGACATCGAAACATACAT,5- ATGGCAGAATCACTTTAAAACGTGGCCCCACCCGCTGCACCCTGTGCATTTTGTACGTTACTGCGAAATGACTCAACG,5- CACATCCAACGAATCACCTCACCGTTATCGTGACTCACTTTCTTTCGCATCGCCGAAGTGCCATAAAAAATATTTTTT,5- TGCGAACAAAAGAGTCATTACAACGAGGAAATAGAAGAAAATGAAAAATTTTCGACAAAATGTATAGTCATTTCTATC,5- ACAAAGGTACCTTCCTGGCCAATCTCACAGATTTAATATAGTAAATTGTCATGCATATGACTCATCCCGAACATGAAA,5- ATTGATTGACTCATTTTCCTCTGACTACTACCAGTTCAAAATGTTAGAGAAAAATAGAAAAGCAGAAAAAATAAATAA,5- GGCGCCACAGTCCGCGTTTGGTTATCCGGCTGACTCATTCTGACTCTTTTTTGGAAAGTGTGGCATGTGCTTCACACA,*,TGAAAAATTC,GACATCGAAA,GCACTTCGGC,GAGTCATTAC,GTAAATTGTC,CCACAGTCCG,TGTGAAGCAC,Add?,*,TGAAAAATTC,GACATCGAAA,GCACTTCGGC,GAGTCATTAC,GTAAATTGTC,CCACAGTCCG,TGTGAAGCAC,Remove.,ATGAAAAAAT,HIS7,ARO4,ILV6,THR4,ARO1,HOM2,PRO3, 2 -?alignments,5- TCTCTCTCCACGGCTAATTAGGTGATCATGAAAAAATGAAAAATTCATGAGAAAAGAGTCAGACATCGAAACATACAT,5- ATGGCAGAATCACTTTAAAACGTGGCCCCACCCGCTGCACCCTGTGCATTTTGTACGTTACTGCGAAATGACTCAACG,5- CACATCCAACGAATCACCTCACCGTTATCGTGACTCACTTTCTTTCGCATCGCCGAAGTGCCATAAAAAATATTTTTT,5- TGCGAACAAAAGAGTCATTACAACGAGGAAATAGAAGAAAATGAAAAATTTTCGACAAAATGTATAGTCATTTCTATC,5- ACAAAGGTACCTTCCTGGCCAATCTCACAGATTTAATATAGTAAATTGTCATGCATATGACTCATCCCGAACATGAAA,5- ATTGATTGACTCATTTTCCTCTGACTACTACCAGTTCAAAATGTTAGAGAAAAATAGAAAAGCAGAAAAAATAAATAA,5- GGCGCCACAGTCCGCGTTTGGTTATCCGGCTGACTCATTCTGACTCTTTTTTGGAAAGTGTGGCATGTGCTTCACACA,*,GACATCGAAA,GCACTTCGGC,GAGTCATTAC,GTAAATTGTC,CCACAGTCCG,TGTGAAGCAC,* *,GACATCGAAAC,GCACTTCGGCG,GAGTCATTACA,GTAAATTGTCA,CCACAGTCCGC,TGTGAAGCACA,HIS7,ARO4,ILV6,THR4,ARO1,HOM2,PRO3, 2 -?alignments,5- TCTCTCTCCACGGCTAATTAGGTGATCATGAAAAAATGAAAAATTCATGAGAAAAGAGTCAGACATCGAAACATACAT,5- ATGGCAGAATCACTTTAAAACGTGGCCCCACCCGCTGCACCCTGTGCATTTTGTACGTTACTGCGAAATGACTCAACG,5- CACATCCAACGAATCACCTCACCGTTATCGTGACTCACTTTCTTTCGCATCGCCGAAGTGCCATAAAAAATATTTTTT,5- TGCGAACAAAAGAGTCATTACAACGAGGAAATAGAAGAAAATGAAAAATTTTCGACAAAATGTATAGTCATTTCTATC,5- ACAAAGGTACCTTCCTGGCCAATCTCACAGATTTAATATAGTAAATTGTCATGCATATGACTCATCCCGAACATGAAA,5- ATTGATTGACTCATTTTCCTCTGACTACTACCAGTTCAAAATGTTAGAGAAAAATAGAAAAGCAGAAAAAATAAATAA,5- GGCGCCACAGTCCGCGTTTGGTTATCCGGCTGACTCATTCTGACTCTTTTTTGGAAAGTGTGGCATGTGCTTCACACA,AAAAGAGTCA,AAATGACTCA,AAGTGAGTCA,AAAAGAGTCA,GGATGAGTCA,AAATGAGTCA,GAATGAGTCA,AAAAGAGTCA,*, ,MAP score = 20.37 (maximum),HIS7,ARO4,ILV6,THR4,ARO1,HOM2,PRO3,5- TCTCTCTCCACGGCTAATTAGGTGATCATGAAAAAATGAAAAATTCATGAGAAAAXAGTCAGACATCGAAACATACAT,5- ATGGCAGAATCACTTTAAAACGTGGCCCCACCCGCTGCACCCTGTGCATTTTGTACGTTACTGCGAAATXACTCAACG,5- CACATCCAACGAATCACCTCACCGTTATCGTGACTXACTTTCTTTCGCATCGCCGAAGTGCCATAAAAAATATTTTTT,5- TGCGAACAAAAXAGTCATTACAACGAGGAAATAGAAGAAAATGAAAAATTTTCGACAAAATGTATAGTCATTTCTATC,5- ACAAAGGTACCTTCCTGGCCAATCTCACAGATTTAATATAGTAAATTGTCATGCATATGACTXATCCCGAACATGAAA,5- ATTGATTGACTXATTTTCCTCTGACTACTACCAGTTCAAAATGTTAGAGAAAAATAGAAAAGCAGAAAAAATAAATAA,5- GGCGCCACAGTCCGCGTTTGGTTATCCGGCTGACTXATTCTGACTXTTTTTTGGAAAGTGTGGCATGTGCTTCACACA,AAAAGAGTCA,AAATGACTCA,AAGTGAGTCA,AAAAGAGTCA,GGATGAGTCA,AAATGAGTCA,GAATGAGTCA,AAAAGAGTCA,*,masking,HIS7,ARO4,ILV6,THR4,ARO1,HOM2,PRO3, . . sampling .,MAP ScoreMaximum a priori log likelihood, .MAP Score = N log R :N - .R - , : -1000 , 10 -2000 5=R.,MAP Score, MAP Score :N ( ) . . ., AlignACE , :248 . 29 . false positive ORFs, AlignACE (), 3311 . :Group specificityPositional bias,Group Specificity Score, MAP Score , . A-rich motifs .Group Specificity Score (ScanACE ). , .,ScanACE, . AlignACE . , .,Positional Bias, ( ScanACE) . .,Clustering, CompareACE. clustering 6 . 1 - 1- -1 ., AlignACE (), AlignACE (), , - clustering 54 , -25 . AlignACE . . S12 RRPE - positional bias . rRMA., AlignACE (),
温馨提示
- 1. 本站所有资源如无特殊说明,都需要本地电脑安装OFFICE2007和PDF阅读器。图纸软件为CAD,CAXA,PROE,UG,SolidWorks等.压缩文件请下载最新的WinRAR软件解压。
- 2. 本站的文档不包含任何第三方提供的附件图纸等,如果需要附件,请联系上传者。文件的所有权益归上传用户所有。
- 3. 本站RAR压缩包中若带图纸,网页内容里面会有图纸预览,若没有图纸预览就没有图纸。
- 4. 未经权益所有人同意不得将文件中的内容挪作商业或盈利用途。
- 5. 人人文库网仅提供信息存储空间,仅对用户上传内容的表现方式做保护处理,对用户上传分享的文档内容本身不做任何修改或编辑,并不能对任何下载内容负责。
- 6. 下载文件中如有侵权或不适当内容,请与我们联系,我们立即纠正。
- 7. 本站不保证下载资源的准确性、安全性和完整性, 同时也不承担用户因使用这些下载资源对自己和他人造成任何形式的伤害或损失。
最新文档
- 《谁的本领大》说课稿课件
- 《诗经》二首课件
- 连续性血液净化护理查房
- 亮眼找秘密课件
- 逆向派遣相关条例解读
- 骨伤疼痛病人的护理
- 视传毕业设计中期汇报
- 《蒲公英旅行记》课件
- 《茅屋被大风所破歌》课件
- 钾代谢紊乱病人的护理
- 人教版三年级语文上册第一次月考试卷含答案
- 毕业设计:平谷新城某高层住宅楼室内给排水、消防与采暖系统设计
- 《装饰艺术运动》课件
- 《公路工程量计算》课件
- 医院建筑综合设计与布局优化
- 阴道镜项目质量管理方案
- 边坡工程第3章 边坡工程地质勘察
- 索思医疗卓越产品系列穿戴式动态心电监测产品
- 全国医药行业特有职业技能竞赛中药调剂员赛项备赛试题库(含答案)
- 房屋交易诚意金合同范本模板
- 《毛泽东思想的形成与发展》参考课件3
评论
0/150
提交评论