某些药物代谢动力学数据.docx

某些药物代谢动力学数据药 物生物利用度（%）尿排泄（%）血浆蛋白结合（%）清除率（mlmin-1kg-1）分布容积（L/kg）半衰期（h）醋丁洛尔 acebutolol3740266.81.22.7阿昔洛韦 aciclovir153075153.370.692.4别嘌醇 allopurinol809010900.460.7618阿米卡星 amikacin-9841.30.272.3胺碘酮 amiodarone4601001.96625d阿米替林 amitriptyline48294.811.51521.5氨苄西林 ampicillin6282181.70.281.3阿斯匹林 aspirin681.4499.30.150.25阿替洛尔 atenolol569452.40.956.1阿曲库铵 atracurium-1-5.50.160.33阿托品 atropine505714225.91.74.3硫唑嘌呤 azathioprine60709086145.10.250.77头孢曲松 ceftriaxone-4690950.240.167.3头孢呋辛 cefuroxime-96330.940.191.7苯丁酸氮芥 chlorambucil871992.60.291.3氯霉素 chloramphenicol759025532.40.944.0氯喹 chloroquine8961611.811541氯噻嗪 chlorothiazide9569294.64.50.201.5氯丙嗪 chlorpromazine3219598862130氯酞酮 chlortalidone6465751.63.944西米替丁 cimetidine6262198.31.02.0环丙沙星 ciprofloxacin6065406.01.84.1顺铂 cisplatin-23-6.30.280.53氯贝特 clofibrate955.796.50.120.1113氯硝西泮 clonazepam981861.553.223可乐定 clonidine9562203.12.112可卡因 cocaine57291322.00.8可待因 codeine5007112.62.9环磷酰胺 cyclophosphamide746.5131.30.787.5环孢霉素 cyclosporine231935.91.25.6氨苯砜 dapsone9315730.61.022地塞米松 dexamethasone782.6683.70.823.0地西泮 diazepam1009032970.0550.546.7d地高辛 digoxin7060250.88-39地尔硫diltiazem44478123.13.7苯海拉明 diphenhydramine721.9786.24.58.5丙吡胺 disopyramide8355-1.20.596.0多巴酚丁胺 dobutamine-590.22.4阿霉素 doxorublicin5157985172530多西环素 doxycycline9341880.530.7516依那普利 enalapril4188504.91.711依诺沙星 enoxacin79600-5红霉素 erythromycin3512849.10.781.6艾司洛尔 esmolol-1551701.90.13乙胺丁醇 ethambutol777958.61.63.1乙醇 ethanol803-0.540.24炔雌醇 ethinylestradiol40-986.31.54.3620法莫替丁 famotidine4567177.11.32.6芬太尼 fentanyl-884134.03.7氟卡尼 flecainide7043615.64.911氟氯西林 flucloxacillin494196-0.110.8氟尿嘧啶 fluorouracil289095584.90.832.5氢化可的松 hydrocortisone-80990.750.152米帕明 imipramine40290.1152318吲哚美辛 indometacin9815902.00.262.4胰岛素 insulin-25-0.080.10.3异烟肼 isoniazid-72903.77.40.671.13.1硝酸异山梨酯 isosorbide dinitrate2230128451.50.85-单硝酸异山梨酯 isosorbide-5-mononitrate93501.810.794.4卡那霉素 kanamycin-9001.40.262.1酮康唑 ketoconazole-1998.42.43.3拉贝洛尔 labetalol18550259.44.9左旋多巴 levodopa-7.7130.81.12.2利多卡因 lidocaine352709.21.11.8林可霉素 lincomycin1002072-0.445锂盐 lithium1009500.350.7922洛伐他汀 lovastatin51095521-1.11.7巯嘌呤 mercaptopurine122219110.560.9美沙酮 methadone9224891.43.835甲氨蝶呤 methotrexate7048342.10.557.2甲氧氯普胺 metoclopramide7620406.23.45.0美托洛尔 metoprolol381011154.23.2甲硝唑 metronidazole9910101.30.748.5美西律 mexiletine87415636.34.99.2米诺环素 minocycline9510011761.01.316米诺地尔 minoxidil-200242.73.1吗啡 morphine2461035243.31.9纳多洛尔 nadolol3473202.91.916纳洛酮 naloxone20-222.11.1萘普生 naproxen99199.70.130.1614新斯的明 neostigmine-67-8.40.71.3尼卡地平 nicardipine193818999.513.41.11.3硝苯地平 nifedipine500967.00.781.8硝西泮 nitrazepam781870.861.926硝酸甘油 nitroglycerin11-2303.32.3min炔诺酮 norethisterone65-80-1.54.3514诺氟沙星 norfloxacin3040263215207.23.25奥美拉唑 omeprazole-195-0.190.4812.3昂丹司琼 ondansetron6010707610122.333.5对乙酰氨基酚 paracetamol88305.00.952.0培氟沙星 pefloxacin190135450.813545哌替啶 pethidine5212558174.43.2苯巴比妥 phenobarbital10024510.0620.5499保泰松 phenybutazone80100196.10.0230.09756苯妥英 phenytoin90289-0.64624吲哚洛尔 pindolol7554518.32.33.6哌拉西林 piperacillin-7116482.60.180.93吡罗昔康 piroxicam-599.30.0360.1548哌唑嗪 prazosin681953.00.62.9泼尼松龙 prednisolone822690958.71.52.2泼尼松 prednisone803753.60.973.6普鲁卡因胺 procainamide8367162.71.93.0异丙嗪 promethazine-7080181312普罗帕酮 propafenone340197-925(PM) 38(EM)普萘洛尔 propafenone260.587164.33.9乙胺嘧啶 pyrimethamine-65870.412.983奎尼丁 quinidine8018874.72.76.2雷尼替丁 ranitidine52691510.41.32.1利福平 rifampin-7893.50.973.5东莨菪碱 scopolamine276-161.42.9索他洛尔 sotalol606054-0.79链激酶 streptokinase-0-0.150.0161.4链霉素 streptomycin-5060481.20.252.6磺胺嘧啶 sulfadiazine10057540.550.299.9磺胺异恶唑 sulfafurazole964991.40.330.156.6磺胺甲恶唑 sulfamethoxazol10014620.320.2110.1舒林酸 sulindac-099.41.5215特布他林 terbutaline1456203.41.814硫喷妥 thiopental-1853.92.39.0替卡西林 ticarcillin-92652.00.211.3噻马洛尔 timolol5015607.32.14.1妥布霉素 tobramycin-90100.980.332.2甲苯磺丁脲 tolbutamid