




已阅读5页,还剩47页未读, 继续免费阅读
版权说明:本文档由用户提供并上传,收益归属内容提供方,若内容存在侵权,请进行举报或认领
文档简介
血液病英文,1,TheDiseasesofHematopoieticandlymphoidsystems,血液病英文,2,Structureandfunction,Hematopoieticandlymphoidsystemiscomposedofmyeloidtissue(bonemarrow)andlymphoidtissues(thymus,spleen,lymphnodesandextranodelymphoidtissues).ThethymusandbonemarrowareoftentermedcentrallymphoidtissuesTheremainingorgansareactivelyinvolvedintheimmuneresponse,andconstitutetheperipherallymphoidtissue.,血液病英文,3,血液病英文,4,血液病英文,5,血液病英文,6,血液病英文,7,Diseases,InfectionandreactiveproliferationsThelymphoidneoplasmasMyeloidneoplasmsHistocyticneoplasms,血液病英文,8,Lymphoidneoplasms,Alllymphoidneoplasmsarederivedfromasingletransformedcellandarethereforemonoclonal.Lymphoidneoplasmsareagroupoftumorsthattheirclinicalmanifestationsandbehaviorvarywidely.Theyareclassifiedasnon-Hodgkinslymphoma(NHLs)andHodgkinsslymphomabasedonthefeaturesoftumorcells.NHLsaccountforabout70%to8014)myc-Igfollicularlymphoma:t(14;18)bcl-2-IgCLL:Philadelphiachromosomet(9,22)c-abl,bcr,血液病英文,17,Etiology(3),3.Autoimmune&immunodeficienyDiseaseeg.Receptoroftransplantedorgans.AIDSpatients,血液病英文,18,lymphoma,血液病英文,19,Leukemia/Lymphoma,Thesearehigh-gradeNHLscomposedofdiffusesheetsofmedium-sizelymphoidcells.TheymaybeB-orT-celllineage.Theseaggressivetumorsaffectpredominantlyinchildren,accountingfor80%ofchildhoodleukemia.Thepre-B-celllymphomamainlyaffectschildren,butthePre-T-celltumorsmainlyaffectadolescentmales.,血液病英文,20,Morphology,Mircoscopically,thelymphnodesaffectedbyneoplasticcellsarereplacedbysmalltomedium-sizedblastcellswithscantcytoplasmandinconspicuousnucleoli.Inbloodsmearslide,thenucleioflymphoblastswithWright-Giemsastainingshowsomewhatcoarseandclumpedchromatinandoneortwonucleoli.,血液病英文,21,Bloodandbonemarrowchanges,Inperipheralblood,thewhitecellcountisusuallyincreased.sometimesmorethan100,000/ul.Anemiaisalmostpresent.Theplateletcountisususllydepressedtolessthan100,000/ul.Bonepainandtendernessresultfrommarrowexpansionwithinfiltrationofthesubperiosteum.Splenomegaly.,血液病英文,22,Immunophenotypeandkaryotype,TdTpresentinmorethan95%ofcasesCD19(Bcellmarker)CD2(Tcellmarker),血液病英文,23,Clinicalfeatures,ThemanifestationsinthesediseasesaresimilartothatofAML.Anemia,hemorrhageandinfectionaswellasrelatedsymptoms,血液病英文,24,Chroniclymphocyticleukemia(CLL)/smalllymphocyticlymphoma(SLL),Infact,smalllymphocticlymphomaandchroniclymphocyticleukemiaarethevirtuallyidenticaltumors.Itisadiseaseaffectingpersonsolderthan50yearsofage.Mostpatientsareleukemicatthetimeofdiagnosis.,血液病英文,25,Morphology,Thelymphnodesarereplacedbysheetsofmaturelymphocytes,whichareround,smallcompactwithdark-stainingroundnuclei,scantycytoplasmanduniforminshapeandsize,andscatteredill-definedfocioflargecellstermedprolymphocytes.Thefociofmitoticactiveprolymphocytesarecalledproliferationcenters,whichareusefulforCLL/SLLindiagnosis.,血液病英文,26,Immunophenotyeandkaryotype,TheneoplasticcellsexpressB-cellmarkers,suchasCD19,CD20,CD23,surfaceimmunoglobulin(e.g.IgM,IgG).,血液病英文,27,血液病英文,28,Clinicalfeatures,CLL/SLLisoftenasymptomatic.manycasesarediagnosedasaresultofroutinebloodtestsorclinicalexaminationforotherreasons.Thesymptomarenonspecific,includingeasyfatigue,weightlossandanorexia.Theprognosisisgoodandthepatientswiththesediseasesmaysurvivefor10yearsormore.Themediansurvivaltimeis4to6years.,血液病英文,29,Diffuse,血液病英文,30,血液病英文,31,Follicularlymphoma,ItisatumorderivedfromgerminalcenterB-cells,characterizedbyanodularorfolliculararchitecture.ItisoneofthecommonesttypeofNHLs.Itaccountsfor10%to40%ofNHLs.Lateadultlifeisapeakageincidence.,血液病英文,32,Immunophenotypeandkaryotype,CD19,CD20.CD10,BCLprotein.Mostofthecaseshavespecificchromosometranslocationinvolvingtheimmunoglobulinheavychainpromoterregionofchromosome14andtheanti-apoptoticgeneBCL12onchromosome18(t14,18)(q32,q21).,血液病英文,33,Follicular,血液病英文,34,血液病英文,35,血液病英文,36,CD20,CD3,血液病英文,37,血液病英文,38,DiffuselargeB-celllymphoma,Adiffusegrowthpattern.Occursmainlyinolderpatients(medianageabout60year)ItischaracterizedbyadiffuseoutgrowthoflargeB-cells,whichmaydisplaycentroblasticofimmunblasticcytology.CD19,CD20,CD79aandIgM,血液病英文,39,Diffuselargecell,centroblastic,血液病英文,40,血液病英文,41,CB,IB,T/HR,ALC,CD30,CD20,CD3,血液病英文,42,Burkittlymphoma,AdistinctivetypeofBcelllymphoma.Itisdndemicinpara-Africaandoccurmuchlesscommonlyinotherregions.Itmainlyaffectchildrenandadolescents.ItisassociatedwithEBVinfectionandmalaria.ItexpressCD10,CD19.,血液病英文,43,Burkittslymphoma,starry-sky,血液病英文,44,Burkittslymphoma,mitoses,血液病英文,45,血液病英文,46,血液病英文,47,PeripheralT-celllymphoma,ItisrelativelycommoninAsiacomparedwithAmericaandEurope.ItisassociatedwithhumanT-cellleukemia/lymphomavirus(HTL1)Themorphologyisvariableinsizeandshapesofcells.Thesamefeaturessuchasthearchitecturesoflymphnodereplacedbythetumorcells.CD2,CD3,CD5,血液病英文,48,Lymphoblastic(T),convoluted,血液病英文,49,Hodgkinslymphoma,Hodgkinslymphoma(alsocalledHodgkinsdisease)isaprimarymalignanttumoroflymphoidtissues.ItischaracterizedbythepresenceofReed-Sternberg(RS)cellsintheinvolvedtissues.Itaccountsfor15%ofalllymphomasandshowsapeakageincidenceinthethirdandfourthdecades.,血液病英文,50,ThereasonsitseparatedfromNHLs,1MorphologicallycharacterizedbythepresenceofdistinctiveR-Scellsadmixedwithavariableinfiltrateofreactive,nonmalignantinflammatorycells.2Itisoftenassociatedwithsomewhatdistinctiveclinicalfeatures,includingsystemicmanifestations,suchasfever.3Itsstereotypicpatternofspreadallowsittobetreateddifferentlythanmostotherlymphoidneoplasm.,血液病英文,51,ClassificationofHodgkinslymphoma,Itisclassifiedbasedontheappearanceoftheabnormalcel
温馨提示
- 1. 本站所有资源如无特殊说明,都需要本地电脑安装OFFICE2007和PDF阅读器。图纸软件为CAD,CAXA,PROE,UG,SolidWorks等.压缩文件请下载最新的WinRAR软件解压。
- 2. 本站的文档不包含任何第三方提供的附件图纸等,如果需要附件,请联系上传者。文件的所有权益归上传用户所有。
- 3. 本站RAR压缩包中若带图纸,网页内容里面会有图纸预览,若没有图纸预览就没有图纸。
- 4. 未经权益所有人同意不得将文件中的内容挪作商业或盈利用途。
- 5. 人人文库网仅提供信息存储空间,仅对用户上传内容的表现方式做保护处理,对用户上传分享的文档内容本身不做任何修改或编辑,并不能对任何下载内容负责。
- 6. 下载文件中如有侵权或不适当内容,请与我们联系,我们立即纠正。
- 7. 本站不保证下载资源的准确性、安全性和完整性, 同时也不承担用户因使用这些下载资源对自己和他人造成任何形式的伤害或损失。
最新文档
- 高校住宅管理办法
- 道路交通安全设施建设项目涉路工程安全评价
- 皋兰县大棚管理办法
- 模具部绩效管理办法
- 高架仓库管理办法
- 物业公共区管理办法
- 留用地用途管理办法
- 乡镇兽医员管理办法
- 业务员经营管理办法
- 瓜州县防洪管理办法
- 2025新修订《代表法》五大亮点解读
- 护理文献综述汇报
- 职业技术学院《机械制造工艺与工艺装备》课程标准 机械制造及自动化
- 【西安交通大学】2025年电力人工智能多模态大模型创新技术及应用报告
- 树根桩施工方案40867
- 2025年轻型民用无人驾驶航空器安全操控(多旋翼)理论备考试题库(含答案)
- 年产3万吨生物基PTT聚合项目环评资料环境影响
- 《特种设备安全法》考试题库120题(含答案)
- 火灾报警控制器、消防联动控制器、火灾报警控制器(联动型)调试检测检验批质量验收记录
- 三次元操作作业指导书范本
- 肾内科护理常规业务学习课件
评论
0/150
提交评论