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局部水肿分类,James G.O. Brien, et al, Treatment of edema, American Family Physician, June 1,2005,Vol 71,Number 11Perrin M, Ramelet AA. Pharmacological Treatment of Primary CVD , Eur JVasc Endovasc Surg. 2011;41:117-125,Bergan JJ, et al. Chronic venous disease. N Engl J Med. 2006; 355:488-498.Bergan JJ, et al. Pathogenesis of primary chronic venous disease: insights from animal models of venous hypertension. J Vasc Surg 2008; 47:183-92.Perrin M, Ramelet AA. Pharmacological Treatment of primary CVD, Eur J Vasc Endovasc Surg. 2011; 41:117-125.Brennan MJ. Lymphedema following the surgical treatment of breast cancer: a review of pathophysiology and treatment. J Pain Symptom Manage 1992; 7:110-6.,水肿的发病机制,静脉活性药物治疗水肿的疗效和地位：获权威临床证据证实,Cochrane系统评价静脉活性药物治疗水肿纳入44篇文献（n=4413）,结果显示：静脉活性药物显著改善静脉性水肿 (RR 0.72，95% CI 0.65; 0.81),Nicolaides A, et al. Management of chronic venous disorders of the lower limbs. Guidelines according to scientific evidence. Int Angiol 2008; 27:1 -59.Amiel R, et al. Pharmacodynamic properties and therapeutic efficacy of Daflon 500mg. Phlebology. 1992; (2):41-44.Perrin M, Ramelet AA. Pharmacological Treatment of primary CVD, Eur J Vasc Endovasc Surg. 2011; 41:117-125.McHale NG, et al. Control of lymphatic pumping: interest of Daflon 500 mg. Phlebology. 1994; (suppl 1):23-25.,爱脉朗作用三大系统，全面消除水肿,静脉系统 1,2 微循环系统 3,1 淋巴系统1,4,Paysant J, et al. Different flavonoids present in the micronized purified flavonoid fraction (Daflon 500mg) contribute to its anti-hyperpermeability effect in the hamster cheek pouch Angiol.2008; 27:81-85.,爱脉朗双重成分协同，抗炎消肿更强效,Allaert FA. Meta-analysis of the impact of the principal venoactive drugs agents on malleolar venous edema. Int Angiol.2012 Aug; 31(4):310-5.,爱脉朗减轻水肿显著优于其他静脉活性药物,静脉活性药物缓解踝部水肿荟萃分析,爱脉朗显著改善静脉性水肿临床文献,Albert Adrien RAMELET ，Management of chronic venous disease : the example of Daflon 500 mg， Phlebolymphology . Vol 16. No. 4. 2009，321-330,爱脉朗安全性好,Katherine A. Lyseng-Williamson，et al. Micronised Purified Flavonoid Fraction A Review of its Use in Chronic Venous Insufficiency, Venous Ulcers and Hemorrhoids .Drugs 2003; 63 (1): 71-100,爱脉朗获国际指南A级推荐,Nicolaides A, et al. Management of chronic venous disorders of the lower limbs. Guidelines according to scientific evidence. Int Angiol. 2008;27: 1-59,作用于静脉、毛细血管及淋巴三大系统,独特抗炎机制，消肿的疗效显著优于其他静脉活性药物,国际指南最高级别推荐,微粒化纯化黄酮（MPFF）在其他领域的研究(供参考),微粒化纯化黄酮（MPFF）显著缓解外伤及手术引起的肿胀,熊伟等.微粒化地奥司明缓解创伤及骨科手术后患者下肢肿胀和疼痛症状的定量评估.Chinese Journal of clinical Rehabilitation .June 14 2005 Vol.9 No.22,P0.05 n = 62,用法：爱脉朗 1片，bid，使用14天。,*,水肿发生率（%）,（n=78）,*,P0.05,（n=74）,爱脉朗用法：1片，t.i.d，使用7天。 对照组：抗生素和镇痛药。,何嘉辉等. 岭南现代临床外科. 2012;12(4):377-378,微粒化纯化黄酮（MPFF）显著降低术后水肿发生率,微粒化纯化黄酮（MPFF）缓解栓子切除术后下肢水肿,Filis KA,et al. Therapeutic efficacy of flavonoids in oedema following reperfusion on acutely ischaemic legs.Int Angiol. 1999 Dec;18(4):327-30.,微粒化纯化黄酮（MPFF）显著改善乳癌术后淋巴循环参数,Pecking AP,et al. Efficacy of Daflon 500 mg in the treatment of lymphedema (secondary to conventional therapy of breast cancer)Angiology 48:93-98, 1997,淋巴流速(cm/分),胶体半衰期（分）,微粒化纯化黄酮（MFPP）显著缓解乳腺癌术后上肢淋巴水肿,袁毅路.爱脉朗治疗乳腺癌术后上肢淋巴水肿20例观察，江苏药学与临床研.2005;13(05):47-49,微粒化纯化黄酮（MPFF）对骨折患者获益更多,Blent zkurt et al.Micronised and puried avonoid fraction prevents oedema formation and regulates peripheral circulation after conservatively treated distal radius fractures.Joint Dis Rel Surg.2008; 19(3):106-111.,微粒化纯化黄酮减轻水肿、提高血氧饱和度,微粒化纯化黄酮（MFPP）显著降低丝虫病引起的淋巴水肿,LK Das, G et al. Some observations on the effect of Daflon (micronized purified flavonoid fract