药学英语之减肥药原理解PPT课件.ppt

.,1,GenericName:SibutraminehydrochlorideProductName:Reductil/Ectiva,.,2,Productname:QuMeiGenericName:Sibutraminehydrochloride,.,3,SibutramineFormula:C17H26ClN,molecule,Chemicalstructure,.,4,Indications:obesity(肥胖症，多脂)！,.,5,pharmacology,Sibutramineisaneurotransmitter(神经递质)reuptake（重吸收）inhibitorthatreducesthereuptakeofserotonin（血清素),norepinephrine（去甲肾上腺素）,anddopamine,therebyincreasingthelevelsofthesesubstancesinsynapticclefts（突触间隙）andhelpingenhancesatiety（饱满感）;theserotonergic（5-羟色胺能）action,inparticular,isthoughttoinfluenceappetite.,.,6,contraindications,Sibutramineiscontraindicatedin:1Psychiatric(精神病学的)conditionsasbulimianervosa（神经性贪食症）,anorexia（厌食症）,seriousdepressionorpreexistingmania（狂躁症）2Patientsbelow18yearsofage3Concomitant（伴行的，并发的）treatmentwithaMAOinhibitor（单胺氧化酶抑制剂）,antidepressantorothercentrallyactivedrugs,particularlyotheranoretics（消瘦剂，减食欲剂）4Hypertensionthatisnotsufficientlycontrolled(cautionincontrolledhypertension)5Existingpulmonaryhypertension（肺动脉高血压）6Pregnantandlactating（泌乳）women,.,7,sideeffects!,Frequentlyencounteredsideeffectsare:drymouth,paradoxicallyincreasedappetite,nausea(恶心),strangetasteinthemouth,upsetstomach,constipation（便秘）,troublesleeping,dizziness,drowsiness（困倦）,menstrualcramps/pain,headache,flushing（面红）,orjoint/musclepain.,.,8,Thefollowingsideeffectsareinfrequentbutseriousandrequireimmediatemedicalattention:cardiacarrhythmias（心律不齐）,paresthesia（感觉异常）,mental/moodchanges(e.g.,excitement,restlessness,confusion,depression,rarethoughtsofsuicide).,Symptomsthatrequireurgentmedicalattentionareseizures（癫痫发作）,problemsurinating（排尿）,abnormalbruising（碰伤）orbleeding,hematemesis（呕血）,feverandrigors（僵直）,chestpain,hemiplegia,（半身不遂）abnormalvision,dyspnea（呼吸困难）andedema.（水肿）,.,9,Suggestion!DonttakeQUMeioranykindofmedicinewhosemainingredientisSibutramine.Moreexerciseandlessfoodisthego