赵仑_09_March_ERP高级培训班讲座(6).ppt

ERPs&Bandextension(MaQG,etal,2007a,b),情绪体验,Cuthbertetal.,(2000).BiologicalPsychology,52,95-111.,P2reflectstheattentionmodulationinearlyperceptualprocessingLatePositivePotential(LPP)indicatesaprocessingthatallocatedtheperceptualprocessingresourcesforsustainedattentiveprocessing,LanguageProcessing&Linguistics,WordSentenceContextLearningSemanticSyntaxVisualandauditorymodality,N400,N400,Processingofincongruousmentalcalculationproblems-AnarithmeticN400effect,(MICHAELNIEDEGGEN,FRANKRSLERandKERSTINJOST,1999),PMN(phonologicalmismatchnegativity)(Connolly,etal,1990,1992,1994)Anegative-goingresponseprecedingtheN400inauditorymodalityispeakedbetween270and300msaftertheonsetoftheterminalwordReflectingacoustic-phoneticprocessingoftheinitialsegmentoftheword(e.g,thesentence-finalword),possiblytheinitialphonemeConnolly&Phillips,1994-InvestigatingtheindependenceofPMNfromN400under4conditions,4conditions:Phonememismatch-Semanticmismatch(PMM-SMM):Joanfedherbabysomewormnose(milk)-PMN&N400Phonememismatch-Semanticmatch(PMM-SM):Theyleftthedirtydishesinthekitchen(sink)-PMNPhonemematch-Semanticmismatch(PM-SMM):Phiputsomedropsinhisicicles(eyes)-N400Phonemematch-Semanticmatch(PM-SM):Atnighttheoldwomanlockedthedoor,(ThehighestClozeprobabilityterminalword),Connolly&Phillips,1994,NeitherthePMNnortheN400wasfoundinthePM-SMconditionOnlyanN400wasobservedinthePM-SMMconditionOnlyaPMNwasseeninthePMM-SMconditionTheN400andthePMNwereelicitedinPMM-SMMconditionAdelayedN400occurredtosemanticviolationinthePM-SMMconditionascomparedwithinthePMM-SMMcondition,Connolly&Phillips,1994,PMM-SMMwasasthebaselinefromwhichthePM-SMMandPMM-SMconditionsweresubtractedInthePMM-SMMcondition,thetwocomponents,PMNandN400,wereelicitedandclarifiedclearly.,Contexthasanearlyeffect,thatis,PMNeffect,onspoken-wordrecognition,ThedifferencesbetweentheMMNselicitedbycomesandcomerecordedatFCzareshownfortheexperimentswherethesewordswerepresentedoutofcontext(redcurves)andincontext(bluecurves)TheungrammaticaldeviantstimuluselicitedalargerMMNthanthecorrectsentenceatleft-anteriorrecordingsitesandthecorticalsourcesofthegrammaticaleffectsrevealedamainsourceintheleftfrontalcortex.,(Pulvermller,etal,2003),Grammarcanbeprocessedautomatically,(Pulvermller,etal,2007),神经精神疾病的认知功能障碍：认知过程认知功能脑机制及其评估,用ERP研究神经精神疾病？,（1）对病例的选择和说明要详细，是否得到治疗，效果如何等，有利于结果的说明；（2）详细说明实验过程中被试的表现情况；（3）临床研究中对照组的选择要与实验组尽量匹配；（4）实验设计是生命，实验技术是根本；（6）设计的简单性、被试任务的完成性；（7）溯源分析不是必要的，基本波形分析（潜伏期、幅值、脑区分布）更重要；（8）个案研究的重要性。,临床ERP研究的注意事项,海马损伤&P3b、P3a,P3b,P3a,（Knight，1997）,ThepatientsafterheadinjurymaynoticeerrorstheNeisnotsignificantlydifferentfromnormalbutnotbeabletocopewiththemthePewaveissignificantreduced.,（BentinS,etal,1999）,Prosopagnosia-theinabilitytorecognizefamiliarfacesSinglecellrecordingsinmonkeysERPsfromthecorticalsurfaceERPsfromthescalpMEGresponsecomponentsfMRIandPETbrainimaging,NeuralMechanismsofFacePerception,WhereDoestheEvidenceComeFrom?,TheoryandQuestion?Results?,HowistheN170modulatedbyfacialexpressions?,Doesearlyfaceprocessingdifferfordifferentexpressions?,ERP论文写作,TensimplerulesfordesigningERPexperiments,SpecificcomponentstudyEMMN(L.Zhao,J.Li,2006)GeneralstudyTitle:Theagingeffectontheearlystageoffaces:AnERPstudy(Gao,etal,inpress)Question:CanIfindevidenceforaneffectofagingon“early”processingoffaces?,Agingaffectsperceptualprocesses(Does?)Facesareanimportantcomplexstimulithathumansprocessfrequentlythroughoutlifespan.Whatisknownaboutfaceprocessingintheelderly?Whydoyouwanttostudytheearlyprocessin