丙酮酸乙酯对脓毒症大鼠T淋巴细胞亚群的影响.ppt

,题目：丙酮酸乙酯对脓毒症大鼠T淋巴细胞亚群的影响TITLE:EffectofethylpyruvateonTlymphocyteinratmodelofsepsis,孟玫王春亭张怡婧张继承山东省立医院加强治疗中心MengMei,WangChun-ting,ZhangYi-jing,ZhangJi-chengIntensiveCareUnitofShandongProvincialHospitalofShandongUniversity,山东省立医院,山东省立医院,丙酮酸乙酯(Ethylpyruvate),研究背景(Backgroud),脓毒症(Sepsis),山东省立医院,研究目的(Objective),山东省立医院,1.研究背景(Background)1.1脓毒症的研究(Researchofsepsis),山东省立医院,1.研究背景(Background)1.2丙酮酸乙酯的研究(Researchofethylpyruvate),山东省立医院,1研究背景(Background)1.3研究目的(Researchobjective),山东省立医院,2研究方法(Methods)2.1实验动物(Experimentalanimal),山东省立医院,2研究方法(Methods)2.2试验步骤(Experimentalprocedures),山东省立医院,2研究方法(Methods)2.3流式细胞仪分析(Flowcytometricanalysis),山东省立医院,2研究方法(Methods)2.4统计分析(Statisticalanalysis),山东省立医院,3结果(Results),山东省立医院,3结果(Results),山东省立医院,Table1.TheCD4/CD8ratioinMLNat48hoursafterCLPoperation,山东省立医院,Figure1Resultsofflowcytometric,ShamgroupEPgroupCLPgroup,CD4+CD3+CD8+CD3+,山东省立医院,4.1讨论(Discussion),山东省立医院,4.2讨论(Discussion),山东省立医院,4.3讨论(Discussion),山东省立医院,参考文献(References)1.FergusonNR,GalleyHF,WebsterNR.Thelpercellsubsetratiosinpatientswithseveresepsis.IntensiveCareMed1999;25:1069.2.RiedemannNC,GuoRF,WardPA.Novelstrategiesforthetreatmentofsepsis.NatMed2003;9:517-24.3.VenkataramanR,KellumJA,SongM,FinkMP.ResuscitationwithRingersethylpyruvatesolutionprolongssurvivalandmodulatesplasmacytokineandnitrite/nitrateconcentrationsinaratmodeloflipopolysaccharide-inducedshock.Shock2002;18:507-12.4.MengesT,EngelJ,WeltersJ,WagnerRM,LittleS,RuwoldtR,WollbruckM,HempelmannG.Changesinbloodlymphocytepopulationsaftermultipletrauma:associationwithposttraumaticcomplications.CritCareMed1999;27:733-740.5.Johannaosterberg,MikaelLjungdahl,UlfHaglund.Influenceofcyclooxygenaseinhibitorsongutimmunecelldistributionandapoptosisrateinexperimentsepsis.Shock2006;25(2):147-154.6.HotchkissRS,TinsleyKW,SwansonPE,SchmiegREJr,HuiJJ,ChangKC,OsborneDF,FreemanBD,CobbJP,BuchmanTG,KarlIE:Sepsis-inducedapoptosiscausesprogressiveprofounddepletionofBandCD4+Tlymphocytesinhumans.JImmunol2001;166:6952-6963.7.OberholzerC,OberholzerA