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1.Introduction 2.CiteSpace 3.Disciplines and topics involved in regenerative medicine 4.The intellectual structure of regenerative medicine 5.Emerging trends 6.Conclusion 7.Expert opinion Review Emerging trends in regenerative medicine: a scientometric analysis in CiteSpace Chaomei Chen, Zhigang Hu, Shengbo Liu 14(10):2350-8 2.Glotzbach JP, Wong VW, Gurtner GC, Longaker MT. Regenerative medicine. Curr Probl Surg 2011;48(3):148-212 3.Polak DJ. Regenerative medicine. Opportunities and challenges: a brief overview. J Royal Soc Interface 2010;7:S777-S81 4.Chin MH, Mason MJ, Xie W, et al. Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell 2009;5(1):111-23 5.Feng Q, Lu S-J, Klimanskaya I, et al. Hemangioblastic derivatives from human induced pluripotent stem cells exhibit limited expansion and early senescence. Stem Cells 2010;28(4):704-12 6.Stadtfeld M, Apostolou E, Akutsu H, et al. 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Generation of mouse induced pluripotent stem cells without viral vectors. Science 2008;322(5903):949-53 32.Boland MJ, Hazen JL, Nazor KL, et al. Adult mice generated from induced pluripotent stem cells. Nature 2009;461(7260):91-4 33.Laurent LC, Ulitsky I, Slavin I, et al. Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell 2011;8(1):106-18 34.Bock C, Kiskinis E, Verstappen G, et al. Reference maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines. Cell 2011;144(3):439-52 35.Boulting GL, Kiskinis E, Croft GF, et al. A functionally characterized test set of human induced pluripotent stem cells. Nat Biotech 2011;29(3):279-86 36.Ben-David U, Benvenisty N. The tumorigenicity of human embryonic and induced pluripotent stem cells. 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Identification and expansion of human colon-cancer-initiating cells. Nature 2007;445(7123):111-15 43.Li C, Heidt DG, Dalerba P, et al. Identification of pancreatic cancer stem cells. Cancer Res 2007;67(3):1030-7 44.Mikkelsen TS, Ku M, Jaffe DB, et al. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 2007;448(7153):553-60 45.Laflamme MA, Chen KY, Naumova AV, et al. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotech 2007;25(9):1015-24 46.Gimble JM, Katz AJ, Bunnell BA. Adipose-derived stem cells for regenerative medicine. Circ Res 2007;100(9):1249-60 47.Phinney DG, Prockop DJ. Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair-current views. Stem Cells 2007;25(11):2896-902 48.Khang G, Kim SH, Kim MS, et al. Recent and future directions of stem cells for the application of regenerative medicine. Tissue Eng Regen Med 2007;4(4):441-70 49.Woltjen K, Michael IP, Mohseni P, et al. piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature 2009;458(7239):766-70 50.Yu J, Hu K, Smuga-Otto K, et al. Human induced pluripotent stem cells free of vector and transgene sequences. Science 2009;324(5928):797-801 51.Zhou H, Wu S, Joo JY, et al. Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell 2009;4(5):381-4 52.Soldner F, Hockemeyer D, Beard C, et al. Parkinsons disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell 2009;136(5):964-77 53.Kaji K, Norrby K, Paca A, et al. Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature 2009;458(7239):771-5 54.Kim D, Kim C-H, Moon J-I, et al. Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell 2009;4(6):472-6 55.Ebert AD, Yu J, Rose FF, et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 2009;457(7227):277-80 56.Kim JB, Sebastiano V, Wu G, et al. Oct4-induced pluripotency in adult neural stem cells. Cell 2009;136(3):411-19 57.Vierbuchen T, Ostermeier A, Pang ZP, et al. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 2010;463(7284):1035-41 58.Lister R, Pelizzola M, Dowen RH, et al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 2009;462(7271):315-22 59.Discher DE, Mooney DJ, Zandstra PW. Growth factors, matrices, and forces combine and control stem cells. Science 2009;324(5935):1673-7 60.Hong H, Takahashi K, Ichisaka T, et al. Suppression of induced pluripotent stem cell
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