蛋白酶切位点

Enzymes E.C. NumberCleavage sitesSerineproteases（丝氨酸蛋白酶）E.C.3.4.21.-chymotrypsin(胰凝乳蛋白酶，糜蛋白酶)E.C.3.4.21.1 Tyr-|-Xaa,Trp-|-Xaa, Phe-|-Xaa, andalsoLeu-|-Xaa,Met-|-Xaa,Trypsin (胰朊酶，胰蛋白酶)E.C.3.4.21.4 Arg-|-Xaa, Lys-|-Xaa,Pancreatic elastase (胰弹性蛋白酶)E.C.3.4.21.36 Ala-|-Xaa,andalsoGly-|-Xaa,Val-|-Xaa, Ser-|-Xaa,Thrombin(凝血酶)E.C.3.4.21.5 Arg-|-Gly,Plasmin(胞质素，胞浆素)E.C.3.4.21.7Lys-|-Xaa,Arg-|-XaaProlyl oligopeptidase,or prolylendopeptidaseE.C.3.4.21.26 Plasma kallikrein (血浆激肽释放酶)E.C.3.4.21.34 Arg-|-Xaa, Lys-|-Xaa,includingArg-|-Ser,Lys-|-Arg,Leukocyteelastase(白细胞弹性蛋白酶),orneutrophilelastase(中性白细胞弹性蛋白酶),orlysosomalelastase(溶酶体弹性蛋白酶)E.C.3.4.21.37Val-|-Xaa, Ala-|-Xaa,Cysteine proteases（半胱氨酸蛋白酶）E.C.3.4.22.Cathepsin B (组织蛋白酶)E.C.3.4.22.1 Arg-Arg-|-Xaa,and also Leu-|-Xaa,Ala-|-Xaa, Phe-|-Xaa, Trp-|-Xaa,Clostripain(梭菌蛋白酶),or endoproteinase Arg-CE.C.3.4.22.8Arg-|-Xaa including Arg-|-Pro,but notLys-|-XaaCalpain(钙激活中性蛋白酶)-1,or -calpainE.C.3.4.22.52 Met-|-Xaa,Tyr-|-Xaa andArg-|-Xaa(with LeuorVal as the P2 residue)Aspartic acid proteases (天冬氨酸蛋白酶)E.C.3.4.23.Pepsin(胃朊酶，胃蛋白酶)E.C.3.4.23.1Preferentially Phe-|-Xaa, Tyr-|-Xaa,And also Leu-|-Xaa,and Trp-|-Xaa, ideally with Xaa= Phe,Trp,orTyrCathepsin(组织蛋白酶)DE.C.3.4.23.5 Preferentially Phe-|-Xaa, Tyr-|-Xaa,And also Leu-|-Xaa,ideally with XaaAlaorValMetalloproteases （金属蛋白酶）E.C.3.4.24.Neprilysin(脑啡肽酶),or enkephalinase(脑啡肽酶),or neutralendopeptidaseE.C.3.4.24.11Xaa-|-Tyr,Xaa-|-Phe, Xaa-|-Trp,andXaa-|-Leu,Thimet oligopeptidase(甲拌磷寡肽 酶),or endo-oligopeptidase A,or endopeptidase(肽链内切 酶)24.15,or pz-peptidease(肠促胰 酶素)E.C.3.4.24.15 Xaa-|-Arg, Xaa-|-Ser,Xaa-|-Ile,Xaa-|-Ala, Xaa-|-Gly,Aminopeptidases （氨肽酶）E.C.3.4.11. N-termLeucyl-aminopeptidaseE.C.3.4.11.1 Preferentially Leu-|-Xaa,but notArg-|-Xaa,andLys-|-Xaa,Aminopeptidase M or N,or alanyl aminopeptidase,or membrane alanine aminopeptidaseE.C.3.4.11.2 Preferentially Ala-|-Xaa,and Tyr-|-Xaa,if Yaa-Pro-|-Xaa in term with Yaa=Ala,Val,Leu,Ile,Phe,Tyr or Trp,then the dipeptide Yaa-Pro could be releasedAminopeptidase BE.C.3.4.11.6 Arg-|-Xaa, Lys-|-Xaa,AminopeptidaseA,or angiotensinase,or glutamyl-aminopeptidaseE.C.3.4.11.7 Glu-|-XaaAsp-|-Xaa,Dipeptidyl-peptidases and tripeptidyl-peptidases （二肽基肽酶和三肽基肽酶）E.C.3.4.14. N-term(di-and tripeptides)Dipeptidyl-peptidaseI,or cathepsin(组织蛋白酶)C or JE.C.3.4.14.1 Xaa-Yaa-|-Zaa,if XaaArgorLys,orYaa Pro,orZaaProDipeptidyl-peptidase IVE.C.3.4.14.5 Preferentially Xaa-Pro-|-Zaa,(but also Xaa-Ala-|-Yaa)withYaa Pro or HypProlyl tripeptyl-peptidase E.C.3.4.14.12 Xaa-Yaa-Pro-|-Zaa,if ZaaPro Peptidyl-Dipeptidases（肽基 - 二肽酶）E.C.3.4.15. C-termPeptidyl-depeptidaseA, or angiotensin-converting enzymeE.C.3.4.15.1 Xaa-|-Yaa-Zaa,if YaaPro or ZaaAsp or GluMetallo-carboxypeptidases（金属羧肽酶）E.C.3.4.17. C-termCarboxypeptidase A E.C.3.4.17.1 Xaa-|-Yaaif Yaa Asp,Glu,Arg,Lys or ProCarboxypeptidase B,or protaminase E.C.3.4.17.2 Xaa-|-ArgandXaa-|-LysCarboxypeptidase N,or Lysine(arginine), Carboxypeptidase(羧基肽酶),or kininase I(激肽酶)E.C.3.4.17.3 Xaa-|-Lys Xaa-|-ArgCarboxypep