感染与心血管疾病

感染与心血管疾病一、一、文献来源二、内容简介三、分析与讨论四、结论与启示一、文献来源一、文献来源1ROLEOFACUTEINFECTIONINTRIGGERINGACUTECORONARYSYNDROMESLANCETINFECTDIS20101083922INFLUENZAANDCARDIOVASCULARDISEASEISTHEREACAUSALRELATIONSHIPTEXHEARTINSTJ20043114133IMMUNOSUPPRESSIVETREATMENTFORINFLAMMATORYCARDIOMYOPATHYINTHEARTJ2005461131224GUIDELINESONTHEPREVENTION,DIAGNOSIS,ANDTREATMENTOFINFECTIVEENDOCARDITISNEWVERSION2009EUROPEANHEARTJOURNAL200930,236924135EFFICACYOFDAPTOMYCININTHETREATMENTOFENTEROCOCCALENDOCARDITISA5YEARCOMPARISONWITHCONVENTIONALTHERAPYJANTIMICROBCHEMOTHER2014FEB13,PMID245326821、感染（INFECTION）系指由细菌、病毒、真菌、衣原体、支原体、立克次体、螺旋体、原虫、蠕虫等病原体所致的疾病。各类病原体可引起多种类型的感染致心血管疾病，使患者健康严重受损和社会负荷沉重不堪。2、感染导致心血管疾病以感染性心包炎、感染性心肌炎和感染性心内膜炎较常见，而感染性心瓣膜病多由感染性心内膜炎引起，感染性血管炎较为少见。3、诊治在尽快留取实验室检查标本（如疑诊感染性心内膜炎患者至少抽3次静脉血进行血培养，采血间隔30MIN1H）后，应根据循证医学和相关指南尽早、足量、经验性选用抗感染药物。二、内容简介二、内容简介三、分析与讨论三、分析与讨论1ROLEOFACUTEINFECTIONINTRIGGERINGACUTECORONARYSYNDROMESLANCETINFECTDIS2010108392ASEVERALMECHANISMSTRIGGERTHEDISRUPTIONOFANADVANCEDCORONARYLESIONTHEDISRUPTEDSURFACEEXPOSESUNDERLYINGTHROMBOGENICMATERIALPLAQUEDISRUPTIONALONEISNOTSUCIENTFORTHEDEVELOPMENTOFANACUTECORONARYSYNDROMEBTHROMBOGENICCONDITIONSLOCALANDSYSTEMICDETERMINETHROMBUSFORMATIONCTHEOCCLUSIVENATUREOFTHETHROMBUSTOTALVSPARTIAL,THEDEGREEOFSTENOSIS,THEPRESENCEOFVASOCONSTRICTION,THECORONARYPERFUSIONPRESSURE,ANDTHEMYOCARDIALMETABOLICBALANCEDEMANDVSSUPPLYDETERMINETHEEVOLUTIONOFANACUTECORONARYSYNDROME2INFLUENZAANDCARDIOVASCULARDISEASEISTHEREACAUSALRELATIONSHIPTEXHEARTINSTJ2004311413TABLEIIEFFECTSOFINFLUENZAONTHECOAGULATIONSYSTEM3IMMUNOSUPPRESSIVETREATMENTFORINFLAMMATORYCARDIOMYOPATHYINTHEARTJ2005461131224GUIDELINESONTHEPREVENTION,DIAGNOSIS,ANDTREATMENTOFINFECTIVEENDOCARDITISNEWVERSION2009EUROPEANHEARTJOURNAL200930,23692413感染性心内膜炎的临床表现感染性心内膜炎的诊断标准5EFFICACYOFDAPTOMYCININTHETREATMENTOFENTEROCOCCALENDOCARDITISA5YEARCOMPARISONWITHCONVENTIONALTHERAPYJANTIMICROBCHEMOTHER2014，13PMID24532682ENTEROCOCCUSSPPACCOUNTFOR10OFINFECTIVEENDOCARDITISIEALTHOUGHDAPTOMYCINISABACTERICIDALDRUGWITHINVITROACTIVITYAGAINSTENTEROCOCCUS,THEREISLITTLEEXPERIENCEOFITSUSEINIETHISWASARETROSPECTIVEDESCRIPTIVESTUDYCOMPARINGTHEEFCACYOFDAPTOMYCINVERSUSAMPICILLIN/CEFTRIAXONEVERSUSCONVENTIONALANTIBIOTICREGIMENSAMPICILLINORVANCOMYCINGENTAMICININEIETABLE1BASELINECHARACTERISTICSOFTHE32PATIENTSWITHENTEROCOCCALINFECTIVEENDOCARDITISDIAGNOSEDDURINGTHESTUDYPERIOD1、感染引起心血管疾病的确诊比较困难，并且往往较晚，起始经验治疗对患者预后有着重要意义。2、病毒性心肌炎以对症支持治疗为主。虽然免疫参与了病程进展，但是抑制免疫的药物并不能改善患者的预后。3、根据ESC及BSAC指