人工绝经的激素替代治疗

1、 sarrel pm and nachtigall lf. individualizing hormone therapy for the surgically menopausal women, oct 20 2004 人工绝经与激素替代人工绝经与激素替代 方案选择方案选择 子宫有无子宫有无 添加雄激素？添加雄激素？ lsome hormone therapy includes testosterone but they are too strong! use care if prescribing. estratest has 4 to 8 times more testosterone

2、than a women should have estratest hs still too much research has shown that the testosterone patch can help with sexual function, but much more research is needed. (proctor 350:1047-59） hrt userisk ratio each year of hrt use1.023 (1.011-1.036) 5 years of hrt use1.35 (1.210-1.400) collaborative grou

3、p on hormone factors in breast cancer lancet 1997;350:1047-59 l e n g th of tim e on h r t e xtra b re ast ca n cers in h r t u se rs, a b o ve the 4 5 o ccu rrin g in n o n -use rs, o ve r 2 0 ye a rs 5 ye a rs use2 p e r 1 0 0 0 1 0 ye a rs use6 p e r 1 0 0 0 1 5 ye a rs use1 2 p e r 1 0 0 0 for w

4、omen aged 50-70 years not using hrt, about 45 in every 1000 will have breast cancer diagnosed over the next 20 years. collaborative group on hormone factors in breast cancer lancet 1997;350:1047-59 子宫内膜组织异位子宫内膜组织异位 内膜癌内膜癌 可考虑极低剂量的局部雌激素疗法， 单独应用或合并局部雌激素的应用 为另一选择是雄激素衍生物，最初用来治疗子宫内膜异 位症 endometrial carci

5、noma is the oestrogen-dependent neoplasm par excellence but is also the female malignancy with the better prognosis. 25% of all women with endometrial cancer are premenopausal and 5% are under 40 years at primary surgery, leading to premature menopause. the concern is that even after uterus removal, oestrogens may stimulate the growth of occult foci of tumour cells. 家族性癌症：家族性癌症：乳腺癌卵巢癌综合征（ breast-ovarian cancer syndrome (brca1 and brca2)）；lynch ii 综 合征，遗传性非息肉性结直肠癌，遗传性位点特