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1、The final examination of medical immunologyfor seven year students of Grade 2003(2005/12/6)Paper BI. Explain the following items(2 points for each, 18 points)1. McAb 2. MAC3. Hapten 4. TCR complex5. Hypersensitivity 6. Clonal anergy7. Heterophile Ag8.ITAM9.PRRII. Choose all correct answers(1 point f
2、or each,15 points)1.Which of the following statement(s) about the spleen is(are) true:A. It filters antigens out of the blood.B. Lymphatic vessels draining the tissue spaces enter the spleenC. It contains germinal centersD. It functions to remove old and defective red blood cells 2.Which kinds of Ig
3、 expressed mainly on the surface of mature B cells? A. mIgG B. mIg A C. mIgD D.mIgM3.Which can function as C3 convertase in activation of complement system?A.C4b2b B.C4b2b3b C.C3bBb D.C3bnBb4.About the characteristics of cytokines, which of the following(s) is (are) correct?A. One cytokine can act o
4、n different cells and play multiple biological effects B. The cytokine produced by one cell only acts on neighbor cells C. Combined with corresponding receptor to play roleD. One cytokine can inhibit or enhance effects of other cytokine5.Which of the following molecules can stimulate T cells activat
5、ion?A. LPSB. PWMC. Con AD. PHA 6.What are the functions of B cells?A. produce AbB. secrete cytokinesC. kill target cells directlyD. present Ag7.Which of the cytokines are secreted by Th1 cells?A. IL-4B. IL-2C. IL-10D. IFN-8.Which of the diseases belong to type hypersensitivity?A. Transfusion reactio
6、nB. Arthus reactionC. Contact dermatitisD. Rheumatoid arthritis9.Which of the following is(are) correct about the characteristics of memory cells? A. Can come from either B cell or T cellB. Can respond to antigen at low consentrate effectivellyC. Only exist in HID. React to a second invasion of an a
7、ntigen more rapidly and stronger10.What abilities do +T cells gain after maturation?A. self-reactiveB. self-toleranceC. express functional TCRD. self MHC restriction 11.Which of the followings are correct statements about dendritic cells?A. Can stimulate nave T cell proliferationB. Express high leve
8、l of MHC class II moleculesC. Express high level of MHC class I moleculesD. Mature dendritic cells with strong function of antigen-capture 12.About AICD, which statements are correct?A. Can be mediated by FasL-Fas interactionB. Is a kind of cell death of activated T cellC. Play important roles in im
9、munological regulationD. IL-4 can promote AICD13. The processes of antigen-activated B cells differentiation in germinal center include:A. Ig Class switchingB. Somatic hypermutation and Ig affinity maturationC. Differentiate into BmD. Apoptosis14.Which of the following factors affect the antigen imm
10、unogenecity?A. molecule weightB. foreignessC. conformationD. chemical composition15. About somatic hypermutation, which statements are correct?A. Occurs during B cells maturationB. Result in affinity maturation of antibodiesC. Mainly occurs in CDR regionD. Can occur during T cells maturationAnswer t
11、he following questions briefly (5 point for each, 30 points)1.Why do NK cells only kill tumor or virus-infected cells but not normal cells?2.Describe functions of three kinds of adhesion molecules which you know.3. How to use immunologic tolerance in clinical medicine? Please give more than two examples.4. Which type of hypersensitivity does allergy asthma belong to? How does it take place?5.How was complement activated in early phage of bacterial infection? 6.Where are the CDR regions located on the antibody molecule and wha
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