CLSI三代头孢菌素折点改变及其临床意义

1、fresno fresno 11/00zhu_11/00zhu_fresno fresno 11/00zhu_11/00zhu_fresno fresno 11/00zhu_11/00zhu_fresno fresno 11/00zhu_11/00zhu_fresno fresno 11/00zhu_11/00zhu_目前我国的临床微生物实验室均以clsi文件作为药敏试验指导文件进行操作和报告fresno fresno 11/00zhu_11/00zhu_fresno fresno 11/00zhu_11/00zhu_ fresno fresno 11/00zhu_11/00zhu_fresn

2、o fresno 11/00zhu_11/00zhu_fresno fresno 11/00zhu_11/00zhu_fresno fresno 11/00zhu_11/00zhu_fresno fresno 11/00zhu_11/00zhu_fresno fresno 11/00zhu_11/00zhu_fresno fresno 11/00zhu_11/00zhu_ 拉氧头孢拉氧头孢 fresno fresno 11/00zhu_11/00zhu_fresno fresno 11/00zhu_11/00zhu_ 除肠杆菌科细菌之外的其他细菌均未进行头孢菌素的折点改变！fresno fre

3、sno 11/00zhu_11/00zhu_fresno fresno 11/00zhu_11/00zhu_*对金葡菌和路登葡萄球菌同时进行对金葡菌和路登葡萄球菌同时进行fox和和oxa药敏时，药敏时，两者只要有一个结果显示耐药就应该报告苯唑西林耐药两者只要有一个结果显示耐药就应该报告苯唑西林耐药fresno fresno 11/00zhu_11/00zhu_fresno fresno 11/00zhu_11/00zhu_fresno fresno 11/00zhu_11/00zhu_breakpointinterpretive standardfresno fresno 11/00zhu_1

4、1/00zhu_fresno fresno 11/00zhu_11/00zhu_fresno 11/00predictors of bacterial eradication: pharmacokinetic/pharmacodynamic profilespenicillinspenicillinscephalosporinscephalosporinscarbapenemscarbapenemsquinolonesquinolonesaminoglycosidesaminoglycosidesmacrolidesmacrolidestelithromycintelithromycindox

5、ycyclinedoxycyclinetime micmic40-50%auc24/micmic25-125fresno fresno 11/00zhu_11/00zhu_*0.75gq8hfresno fresno 11/00zhu_11/00zhu_fresno fresno 11/00zhu_11/00zhu_.likelihood of clinical success and failure is related to many variablesfresno fresno 11/00zhu_11/00zhu_fresno fresno 11/00zhu_11/00zhu_fresn

6、o fresno 11/00zhu_11/00zhu_13296株肠杆菌科细菌头孢噻肟纸片法药敏株肠杆菌科细菌头孢噻肟纸片法药敏 抑菌圈直径的分布抑菌圈直径的分布2008年中国年中国chinet资料资料使用新折点使肠杆菌科细菌对头孢噻肟的耐药率提高了使用新折点使肠杆菌科细菌对头孢噻肟的耐药率提高了clsi2009clsi2010s=45.7%i=10.6%r=43.7%r=54.3%i=4.3%s=41.1%fresno fresno 11/00zhu_11/00zhu_52.6%9.7%37.7%62.3%62.3%2.2%35.5%clsi2009clsi20102008年中国年中国chi

7、net资料资料使用新折点使大肠埃希菌对头孢噻肟的耐药率提高了使用新折点使大肠埃希菌对头孢噻肟的耐药率提高了fresno fresno 11/00zhu_11/00zhu_2009clsi2010clsi 3752株产esbl大肠埃希菌头孢噻肟纸片法 药敏抑菌圈直径的分布s=0.8%s= 1.4%i=0.5%r=98.6%i=11.4%r=87.3%2008年中国年中国chinet资料资料使用新折点使产使用新折点使产esbls大肠埃希菌对头孢噻肟的耐药率提高了大肠埃希菌对头孢噻肟的耐药率提高了fresno fresno 11/00zhu_11/00zhu_fresno fresno 11/00zhu_11/00zhu_fresno fresno 11/00zhu_11/00zhu_fresno fresno 11/00zhu_11/00zhu_fresno fresno 11/00zhu_11/00zhu_fresno fresn