肿瘤标志物的研究历史

1、本科癌基因与抑癌基因1本科癌基因与抑癌基因2本科癌基因与抑癌基因3本科癌基因与抑癌基因4原癌基因一类编码关键性调控蛋白质的正常细胞基因，发生恶变后转变为癌基因的基因序列。生长因子生长因子受体gtp酶蛋白激酶 核蛋白 dna合成siserbamosablerbbyesfmssrcrasmycmybfosjunskiros癌基因能参与或直接导致正常细胞发生恶变的任何基因序列。本科癌基因与抑癌基因5本科癌基因与抑癌基因6本科癌基因与抑癌基因7本科癌基因与抑癌基因8本科癌基因与抑癌基因9本科癌基因与抑癌基因10oncogenmutationtumorprotein functionh-rasgtpas

2、e acitivitynucleotide exchang ratebladdergtpasek-rasgtpase acitivitynucleotide exchang ratecolorectalpancreaticlunggtpasen-rasgtpase acitivitynucleotide exchang rateacute myeloidleukemiagtpaseretextracellular domainmultiple endocrineneoplasia type 2areceptor tyrosinekinaseretkinase domainmultiple en

3、docrineneoplasia type 2breceptor tyrosinekinasemetkinase domainhereditarypapillary renalcarcinomareceptor tyrosinekinasekitkinase domainmast cell leukemiareceptor tyrosinekinasecdk4loss of interaction withp16melanomacell cycle regulator本科癌基因与抑癌基因11oncogentumorprotein functionc-mycsclcpromyelocytic l

4、eukemiaglioblastomatranscription factorn-mycsclcneuroblastomaglioblastomatranscription factorl-mycsclctranscription factoregfrglioblastomareceptor tyrosine kinaseher-2breastgastricovarianreceptor tyrosine kinasecyclin d1hepatic and esophagealsquamous cell carcinomaof the head and neckcell cycle regu

5、latorsclc: small cell lung carcinoma本科癌基因与抑癌基因12oncogentranslocationtumorprotein functionc-myct(8;14)(q24;q32)t(2;8)(p12;q24)t(8;22)(q24;q11)burkitts lymphomatranscription factorbcr-ablt(9;22)(q23;q11)chronic myelogenousleukemianon-receptortyrosine kinasetrknot mappedpapillary thyroidcarcinomarecept

6、or tyrosinekinaseretinv(10)(q11.2;q21)papillary thyroidcarcinomareceptor tyrosinekinasepdgfrt(5;12)(q33;q13)chronic myelomonocyticleukemiareceptor tyrosinekinasebcl-1(cyclin d1)t(11;14)(q13;q32)b-cell lymphomacell cycle regulatorprad-1(cyclin d1)inv(11)(p15;q13)parathyroid adenomacell cycle regulato

7、rbcl-2t(14;18)(q32;q21)parathyroid adenomacell cycle regulator本科癌基因与抑癌基因13本科癌基因与抑癌基因14本科癌基因与抑癌基因15本科癌基因与抑癌基因16本科癌基因与抑癌基因17本科癌基因与抑癌基因18本科癌基因与抑癌基因19本科癌基因与抑癌基因20本科癌基因与抑癌基因21本科癌基因与抑癌基因22本科癌基因与抑癌基因23本科癌基因与抑癌基因24本科癌基因与抑癌基因25本科癌基因与抑癌基因26本科癌基因与抑癌基因27本科癌基因与抑癌基因28本科癌基因与抑癌基因29本科癌基因与抑癌基因30本科癌基因与抑癌基因31本科癌基因与抑癌基因

8、32本科癌基因与抑癌基因33本科癌基因与抑癌基因34本科癌基因与抑癌基因35本科癌基因与抑癌基因36本科癌基因与抑癌基因37本科癌基因与抑癌基因38 本科癌基因与抑癌基因39本科癌基因与抑癌基因40本科癌基因与抑癌基因41本科癌基因与抑癌基因42本科癌基因与抑癌基因43本科癌基因与抑癌基因44本科癌基因与抑癌基因45本科癌基因与抑癌基因46本科癌基因与抑癌基因47本科癌基因与抑癌基因48本科癌基因与抑癌基因49本科癌基因与抑癌基因50g2mg1srbrbe2fe2fppprb dephospholatede2f releasedactivates transcriptionrb binds e

9、2f blocks g1/s transitionrbppprb phospholatedrb phospholationrelease cycle blockrepresses target genesrb-tumor suppressor本科癌基因与抑癌基因51本科癌基因与抑癌基因52 本科癌基因与抑癌基因53本科癌基因与抑癌基因54本科癌基因与抑癌基因55本科癌基因与抑癌基因56本科癌基因与抑癌基因57本科癌基因与抑癌基因58本科癌基因与抑癌基因59dna damage p53inhibition of cyclin/cdk complexes pcna bax fas bcl-2rea

10、ctiveoxygen speciescell-cycle arrest at g1apoptosisinhibition of dna replication p21 gadd45other effectstranscriptionaleffects本科癌基因与抑癌基因60本科癌基因与抑癌基因61本科癌基因与抑癌基因62本科癌基因与抑癌基因63本科癌基因与抑癌基因6412345本科癌基因与抑癌基因65本科癌基因与抑癌基因66本科癌基因与抑癌基因67本科癌基因与抑癌基因68本科癌基因与抑癌基因69本科癌基因与抑癌基因70本科癌基因与抑癌基因71本科癌基因与抑癌基因72本科癌基因与抑癌基因73本

11、科癌基因与抑癌基因744、southern blotdna digestion with restriction endonucleasetransfer of the dna to a membranehybridization with a specific probeautographyelectrophoresis of the dna本科癌基因与抑癌基因75single-color fishdouble-color fishdetection of the bcr, abl and bcr-abl genes by single- and dual-color fluorescence in situ hybridization (fish). represents signals for abl, for bcr. chr