食欲调控外周、中枢与应激

1、食欲调控-外周、中枢与应激Appetite Regulation-Peripheral, Central and the Role of Stress宋志刚山东农业大学动物科技学院Richards MP, Proszkowiec-Weglarz M. 2007. Mechanisms regulating feed intake, energy expenditure, and body weight in poultry. Poult Sci. 86:1478-90.Hormonal regulation of appetitenOrexin （食欲素）（食欲素）nLeptin(瘦素瘦素)

2、nInsulin(胰岛素胰岛素)nAdiponectin (脂联素脂联素 )nGhrelin（生长素）（生长素）nPYYnPP(胰多肽)nGLP-1 (胰高血糖素样肽1)nOXM(胃泌酸调节素)nCCK(胆囊收缩素)Stanley S, Wynne K, McGowan B, Bloom S. 2005. Hormonal regulation of food intake. Physiol Rev. 85: 1131-58.Nutrient regulation of feed intakenFatty acid (脂肪酸脂肪酸)nGlucose (葡萄糖葡萄糖)nAmino acid (氨

3、基酸氨基酸)Carol K.L. Lam, Madhu Chari and Tony K.T.Lam. 2009. CNS regulation of glucose homeostasis. Physiology. 24: 159-170.Tony K.T. Lam, Gary J. Schwartz and Luciano Rossetti. 2005. Hypothalamic sensing of fatty acids. Nature Neuroscience. 8: 579-584.Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Wo

4、ods SC, Seeley RJ. 2006. Hypothalamic mTOR signaling regulates food intake. Science. 312: 927-30.Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferr P, Birnbaum MJ, Stuck BJ, Kahn BB. 2004. AMP-kinase regulates food intake by responding to hormonal and nutrient signals i

5、n the hypothalamus. Nature. 428: 569-74.Richards MP, Proszkowiec-Weglarz M. 2007. Mechanisms regulating feed intake, energy expenditure, and body weight in poultry. Poult Sci. 86:1478-90.Fig. 1a. Effect on AMPK mRNA expressionAMPK 1AMPK 2LKB1Relative mRNA level (as of 7 d) 0.0.2.4.6.81.01.21.41.61.8

6、7d 8d 9d aababbabaEffects of feeding ad lib (7d), fasting (8d) and refeeding (9d) on hypothalamic AMPK and (an)orexigenic peptide mRNA levelsZ. Song, L. Liu, H. Lin, E. Decuypere and J. Buyse. 2010. Fasting induces an increase in AMPK2 gene expression in the hypothalamus of broiler chicks. Meeting a

7、bstract, Pama, Italy.Shimizu H, Arima H, Ozawa Y, Watanabe M, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y. 2010. Glucocorticoids increase NPY gene expression in the arcuate nucleus by inhibiting mTOR signaling in rat hypothalamic organotypic cultures. Peptides. 31: 145-9.Shimizu H, Arima H, Oza

8、wa Y, Watanabe M, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y. 2010. Glucocorticoids increase NPY gene expression in the arcuate nucleus by inhibiting mTOR signaling in rat hypothalamic organotypic cultures. Peptides. 31: 145-9.Lei Liu, Lixian Zhu, A. Sheikh Ahmadi, Zhigang Song, Hongchao Jiao,

9、 Hai Lin. 2010. Heat stress and corticosterone contribute differently to the expression of appetite-related genes in laying hens. Poult. Sci. (submitted)Lei Liu, Lixian Zhu, A. Sheikh Ahmadi, Zhigang Song, Hongchao Jiao, Hai Lin. 2010. Heat stress and corticosterone contribute differently to the expression of appetite-related genes in laying hens. Poult. Sci. (submitte