临床药学 文献阅读汇报 抗感染粘菌素在治疗鲍曼不动杆菌感染VAP中的应用

1、粘菌素在鲍曼不动杆菌感染粘菌素在鲍曼不动杆菌感染VAP中的治疗效果中的治疗效果 陈陈 延延 杰杰 2013.7.421俞云松.多药耐药鲍曼不动杆菌21世纪革兰阴性茵的“MRSA”J.中华临床感染病杂志,2009,2(2):65-68. 多药耐药多药耐药MDRAB、全耐药、全耐药PDRAB、广泛耐药、广泛耐药XDRAB2施毅.正确应对不动杆菌肺部感染J.中国呼吸与危重监护杂志,2012,11(1):13-14.3中国鲍曼不动杆菌感染诊治与防控专家共识,中华医学杂志,2012,92(2);76-85.Literature 14F imek, H Gedik, MT Yldrmak,et al. C

2、olistin against colistin-only-susceptible Acinetobacter baumannii-related infections: Monotherapy or combination therapy?J. Indian Journal of Medical Microbiology, 2012, 30(4): 448-52.VAPClinical responseP=0.821Microbiological responseP=0.113Literature 25 H.AYDEMIR1, D. AKDUMAN,N.PISKIN,et al. Colis

3、tin vs. the combination of colistin and rifampicin for thetreatment of carbapenem-resistant Acinetobacter baumannii ventilator-associated pneumoniaJ. Epidemiol. Infect, 2012:1-9.43名患者在治疗期间，有名患者在治疗期间，有10名患者（名患者（23%）出现了肾毒性。）出现了肾毒性。Literature 36 Qin Lu, M.D., Ph.D., Rubin Luo M.D., Liliane Bodin, M.D.,

4、et al. Efficacy of High-dose Nebulized Colistin in Ventilator-associated Pneumonia Caused by Multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumanniiJ. Anesthesiology ,2012,117(6):1335-47 .500iu常规用量常规用量200-400iucolistin monotherapycolistin combinationClinical cure67%68%Summary1俞云松俞云松.多

5、药耐药鲍曼不动杆菌多药耐药鲍曼不动杆菌21世纪革兰阴性茵的世纪革兰阴性茵的“MRSA”J.中华临床感染中华临床感染病杂志病杂志,2009,2(2):65-68.2施毅施毅.正确应对不动杆菌肺部感染正确应对不动杆菌肺部感染J.中国呼吸与危重监护志中国呼吸与危重监护志,2012,11(1):13-14.3中国鲍曼不动杆菌感染诊治与防控专家共识中国鲍曼不动杆菌感染诊治与防控专家共识,中华医学杂志，中华医学杂志，2012,92(2):76-85.4F imek, H Gedik, MT Yldrmak,et al. Colistin against colistin-only-susceptible

6、Acinetobacter baumannii-related infections: Monotherapy or combination therapy?J. Indian Journal of Medical Microbiology, 2012, 30(4): 448-452.5 H.AYDEMIR1, D. AKDUMAN,N.PISKIN,et al. Colistin vs. the combination of colistin and rifampicin for thetreatment of carbapenem-resistant Acinetobacter baumannii ventilator-associated pneumoniaJ. Epidemiol. Infect, 2012:1-9.6 Qin Lu, M.D., Ph.D., Rubin Luo M.D., Liliane Bodin, M.D.,et al. Efficacy of High-dose Nebulized Colistin in Ventilator-associated Pneumonia Caused by Mult