常见肿瘤化疗方案

1、常见肿瘤化疗方案2004.10.30一、头颈部癌1、DDP+5-FuCisplatin,“,2100mg/mi.v.(1h inf )d15-Fluorouracil21000mg/mi.v.(cont inf )d1-4(5)34周重复,也可附十放疗前2、CBP+5-FuCarboplatin2300mg/mi.v.d15-Fluorouracil21000mg/mi.v.(cont inf )d1-434周重复3、IPIfosfamide 异环磷酰胺21500mg/mi.v.Mesna 保护d1-5Cisplatin10mg/m2i.v.(30min inf )d1-54周重复4、TIPP

2、aclitaxel (紫杉醇)2175mg/mi.v.(3h inf )d1Ifosfamide21000mg/mi.v.(2h, Mesna 保护)d1-3Cisplatin260mg/mi.v.d134周重复5、TICPaclitaxel2175mg/mi.v.(3h inf )d1Ifosfamide21000mg/mi.v.(2h, Mesna 保护)d1-3CarboplatinAUC=6i.v.(30min inf )d134周重复6、Docetaxel+CisplatinDocetaxel 多西紫杉醇2100mg/mi.v.11h inf )d1Cisplatin275mg/mi

3、.v.(3h inf )d13周重复7、Docetaxel+Cisplatin+5-Fluororacil(TPF)Docetaxel275mg/mi.v.d1Cisplatin2100mg/mi.v.d15-Fluorouracil21000mg/mi.v.(cont inf )d1-43周重复8、PBFCisplatin一, 2100mg/mi.v.(1h inf )d1Bleomycin 博来霉素15mgi.v.(bolus )d1 followed by216mg/mi.v.(cont inf )d1-55-Fluorouracil2650mg/mi.v.(cont inf )d1-5

4、4周重复9、BECCisplatin2100mg/mi.v.(1h inf )d1Epirubicin 表柔比星270mg/mi.v.(bolus )d1Bleomycin15mgi.v.(bolus )d1 followed by212mg/mi.v.(cont inf )d1-54周重复二、乳腺癌1、经典CMFCyclophosphamide (环磷2酰胺100mg/mp.o.d1-14Methotrexate (氨甲喋2吟40mg/mi.v.d1,85-Fluorouracil2600mg/mi.v.d1,84周重复2、改进CMFCyclophosphamide2600mg/mi.v.d

5、1Methotrexate240mg/mi.v.d15-Fluorouracil2600mg/mi.v.d13周重复3、ACDoxorubicin 阿霉素化2疗药物60mg/mi.v.d1Cyclophosphamide2600mg/mi.v.d1(,8)3周重复4、ECEpirubicin260mg/mi.v.d1Cyclophosphamide2600mg/mi.v.d13周重复5、IEIfosfamide22000mg/mi.v.Mesna 保护d1,8Epirubicin230mg/mi.v.d1,83周重复6、AC+TDoxorubicinCyclophosphamide“,260m

6、g/m 2600mg/mi.v.i.v.d1d13周重复,共4周期,然后Paclitaxel2175mg/mi.v. (3h inf )d13周重复,共4周期7、CAFCyclophosphamide2500mg/mi.v.d1Doxorubicin250mg/mi.v.d15-Fluorouracil2500mg/mi.v.d13周重复8、CEFCyclophosphamide2500mg/mi.v.d1Epirubicin2100mg/mi.v.d15-Fluorouracil2500mg/mi.v.d13周重复9、Paclitaxel 单药Paclitaxel2175 或 200mg/m

7、i.v. (3h inf )d13周重复10、TADoxorubicin250mg/mi.v.d1Paclitaxel2220mg/mi.v. (3h inf )d2(ADM后 24h)3周重复11、Docetaxel 单药Docetaxel275 或 100mg/mi.v. 11h inf )d13周重复或者Docetaxel240mg/mi.v. 11h inf )qw*4/6w3周重复12、Docetaxel+DoxorubicinDoxorubicin250mg/mi.v.d1Docetaxel275mg/mi.v. (1h inf )d13周重复13、Vinorelbine+Doxo

8、rubicinDoxorubicin一一.240-50mg/mi.v.d1Vinorelbine220-25mg/mi.v.d1,83周重复14、Capecitabine 单药Capecitabine22510mg/mp.o.分两次/天,3周重复15、Trastuzumab 单药Trastuzumab4mg/kgi.v. (90 min inf )负荷量2mg/kgi.v. (30 min inf )维持量,qw三、肺癌一小细胞肺癌的化疗SCLC1、CAOCyclophosphamide21000mg/mi.v.d1Doxorubicin (阿奇霉2素50mg/mi.v.d1Vincristi

9、ne2mgi.v.d13周重复2、CEVCyclophosphamide21000mg/mi.v.d1Epirubicin270mg/mi.v.d1Vincristine2mgi.v.d13周重复3、EPCisplatin280mg/mi.v. 11h inf )d1Etoposide2100mg/mi.v. (2h inf )d1-33周重复4、ECCarboplatin2300mg/mi.v.d1Etoposide2120mg/mi.v. (2h inf )d1-34周重复5、CAECyclophosphamide21000mg/mi.v.d1Doxorubicin240-50mg/mi.

10、v.d1Etoposide2100-120mg/mi.v. 11h inf )d1-33周重复d1-146、VIPEtoposide75mg/mi.v.d1-4Ifosfamide 21200mg/mi.v. (Mesna 保护)d1-4Cisplatin220mg/mi.v.d1-43周重复7、Topotecan 单药Topotecan1.5mg/m2i.v. (30min inf )d1-53周重复8、Paclitaxel+CarboplatinPaclitaxel2175mg/mi.v. (3h inf )d1CarboplatinAUC=7i.v. (30min inf )d13周重复

11、二非小细胞肺癌的化疗(NSCLC1、Docetaxel 单药Docetaxel75mg/m2i.v. (1h inf )d13周重复2、Gemcitabine 单药Gemcitabine21000-1250mg/m2i.v. (30min inf )d1,8,154周重复3、Vinorelbine 单药Vinorelbine230mg/mi.v. (20min inf )d1,8,154周重复4、NPVinorelbine225mg/mi.v.d1,8,15Cisplatin2100mg/mi.v.d14周重复5、Paclitaxel+CisplatinPaclitaxel2175mg/mi.

12、v. (3h inf )d1Cisplatin280mg/mi.v. (1h inf )d13周重复6、 Paclitaxel+CarboplatinPaclitaxel2225mg/mi.v. (3h inf )d1CarboplatinAUC=6i.v.d13周重复7、Docetaxel+CisplatinDocetaxel-7广 /二75mg/mi.v.diCisplatin75mg/mi.v.di3周重复8、Gemcitabine+CisplatinGemcitabine 21000mg/mi.v. (30-60min inf )d1,8,15Cisplatin2100mg/mi.v.

13、 (30-60min inf )di4周重复9、EPCisplatin2100mg/mi.v. (30-60min inf )diEtoposide2100mg/mi.v. (2h inf )di-33周重复四、食管癌1、DDP+5-FuCisplatin2100mg/mi.v. (2h inf )di5-Fluorouracil21000mg/mi.v. (cont inf )di-534周重复2、Paclitaxel+CisptatinPaclitaxel2180mg/mi.v. (3h inf )diCisplatin260mg/mi.v. (3h inf )di3周重复3、 TPEPa

14、clitaxel50mg/m2i.v. (1h inf )di,4Cisplatin215mg/mi.v. (1h inf )di,4Etoposide250mg/mi.v. (cont inf )di,4QW*3休息1周,4疗程4、ECFEpirubicin50mg/m2i.v.diCisplatin260mg/mi.v.di5-Fluorouracil2200mg/mi.v. (cont inf )di-2i3周重复五、胃癌1 、 5-Fu+CF+DDPCisplatin250mg/mi.v. (1h inf )biwFolinic acid500mg/mi.v.(2h inf )qw*6

15、5-Fluorouracil . 22000mg/mi.v.(24h inf )qw*62、ECFEpirubicin250mg/mi.v.d1Cisplatin260mg/mi.v.d15-Fluorouracil2200mg/mi.v.(cont inf )d1-213周重复3、FAMTXMethotrexate211.5g/mi.v.d15-Fluorouracil21500mg/mi.v.d1Doxorubicin230mg/mi.v.d15Folinic acid15mg/m2p.o.MTX 24h, q6h*124周重复4、 ELFEtoposide2120mg/mi.v.(50m

16、in inf )d1-3Folinic acid2300mg/mi.v.(10min inf )d1-35-Fluorouracil2500mg/mi.v.(10min inf )d1-334周重复5 、 TCDocetaxel285mg/mi.v.(1h inf )d1Cisplatin275mg/mi.v.(1h inf )d13周重复六、大肠癌1、Mayo ClinicFolinic acid220mg/mi.v.(bolus )d1-55-Fluorouracil2425mg/mi.v.(bolus )d1-54周重复2、de GramontFolinic acid2200mg/mi.

17、v.(2h inf )d1-25-Fluorouracil2400mg/mi.v.(bolus )d1-22600mg/mi.v.(22h inf )d1-22周重复3、 Irinotecan MonotherapyIrinotecan2125mg/mi.v.(90min inf )qw*46周重复或者Irinotecan .2300-350mg/mi.v.(90min inf )d13周重复4、FOLFORIIrinotecan2125mg/mi.v.(90min inf )qw*4Folinic acid20mg/m2i.v.(bolus )qw*45-Fluorouracil2500mg

18、/mi.v.(bolus )qw*46周重复或者Irinotecan2180mg/mi.v.(90min inf )d1Folinic acid2200mg/mi.v.(2h inf )d1-25-Fluorouracil2400mg/mi.v.(bolus )d1-22600mg/mi.v.(22h inf )d1-22周重复5、Irinotecan+OxaliplatinIrinotecan2200mg/mi.v.(30min inf )d1Oxaliplatin285mg/mi.v.(2h inf )d13周重复6、Oxaliplatin MonotherapyOxaliplatin21

19、30mg/mi.v.(2h inf )d13周重复7、FOLFOX4Oxaliplatin285mg/mi.v.(2h inf )d1Folinic acid2200mg/mi.v.(2h inf )d1-25-Fluorouracil2400mg/mi.v.(bolus )d1-22600mg/mi.v.(22h inf )d1-22周重复8、FOLFOX6Oxaliplatin2100mg/mi.v.(2h inf )d1Folinic acid2400mg/mi.v.(2h inf )d15-Fluorouracil2400mg/mi.v.(bolus )d1-2224003000mg/

20、mi.v.(46h inf )d1-22周重复9、RaltitrexedRaltitrexed3mg/mi.v.d13周重复10、CapecitabineCapecitabine21250mg/mp.o.bid*143周重复11、UFT+CFUFT2100mg/mp.o.tid*28Folinic acid230mg/mp.o.tid*285周重复七、胰腺癌1、Gemcitabine2Gemcitabine 1000mg/mi.v. ( 30min inf )qw*7;休息1周后每周1次,连用3周,4疗程2、5-Fluorouracil5-Fluorouracil2500mg/mi.v.(bo

21、lus )d1-54周重复3、 CF+5-FuFolinic acid220mg/mi.v. (2h inf )d1-55-Fluorouracil2425mg/mi.v. (bolus)d1-54周重复4、 Gemcitabine+CF+5-FuGemcitabine21000mg/mi.v. (30min inf)d1,8,15,22Folinic acid2200mg/mi.v. (2h inf )d1,8,15,225-Fluorouracil2750mg/mi.v. (cont inf )d1,8,15,226周重复八、胆管癌1、5-Fluorouracil5-Fluorouraci

22、l2500mg/mi.v.d1-54周重复或者5-Fluorouracil2600mg/mi.v.d1,8,154周重复2、GemcitabineGemcitabine21000mg/mi.v. (30min inf)d1,8,154周重复3、GemcitabineGemcitabine 22200mg/mi.v.(30min inf)di2周重复4、DocetaxelDocetaxel, V,2100mg/mi.v.(1h inf )d13周重复5、FLMFolinic acid2200mg/mi.v.d1-45-Fluorouracil2400mg/mi.v.d1-4Mitomycin28

23、mg/mi.v.d14周重复6、5-Fu+IFN-a5-Fluorouracil2750mg/mi.v.(cont inf :d1-5Interferon alpha5*10 6IUs.c.d1,3,52周重复九、宫颈癌1、IP2i.v.(24h inf ,Mesna 保Ifosfamide5000mg/m护d1Cisplatin250mg/mi.v.d13周重复2、IC2i.v.(24h inf ,Mesna 保Ifosfamide5000mg/m护esnad1Carboplatin2300mg/mi.v.d14周重复3、 BIPBleomycin230mg/mi.v.(24h inf )d

24、12i.v.(24h inf ,Mesna 保Ifosfamide5000mg/m护d2Cisplatin250mg/mi.v.d24周重复4、TIPPaclitaxel2175mg/mi.v.(3h inf )d12i.v.(24h inf ,MesnaIfosfamide5000mg/m护d2CisplatinLC,250mg/mi.v.d24周重复5、TPPaclitaxel2135mg/mi.v.(24h inf )d1Cisplatin25075mg/mi.v.d23周重复6、PFCisplatin275mg/mi.v.d15-Fluorouracil21000mg/mi.v.(co

25、nt inf )d1-43周重复,也可同时合并放疗十、子宫内膜癌1、APDoxorubicin260mg/mi.v.d1Cisplatin5060mg/m2i.v.d13周重复2、TCPaclitaxel2175mg/mi.v.(3h inf )d1CarboplatinAUC=57i.v.(30min inf )d13周重复3、 PCDDoxorubicin245mg/mi.v.d1Paclitaxel2160mg/mi.v.(3h inf )d1Cisplatin260mg/mi.v.(1h inf )d13周重复,G-CSF支持广、卵巢癌一线化疗1、TPPaclitaxel2135mg/

26、mi.v.(3h 或 24h inf )d1Cisplatin75mg/m2i.v.(1mg/min)d1 或 d23周重复2、TCPaclitaxel2175mg/mi.v.(3h inf )d1CarboplatinAUC=56i.v.(1h inf )d13周重复3、CBP+CTXCyclophosphamide 2600mg/mi.v.d1Carboplatin2300mg/mi.v.(1h inf )d14周重复挽救治疗1、TopotecanTopotecan21.01.5mg/mi.v.(30min inf )d1-53周重复2、EtoposideEtoposide250100mg

27、/mp.o.d1-143周重复3、 GemcitabineGemcitabine28001250mg/mi.v.30min inf )d1,8,154周重复4、IfosfamideIfosfamide2i.v.30min2h inf,Mesna 一 一12002400mg/m2保护d1-534周重复或者Ifosfamide2i.v. (con inf . Mesna 保1000mg/m护d1-74周重复5、IPIfosfamide21500mg/mi.v. (1h inf , Mesna保护)d2-5Paclitaxel2175mg/mi.v. (3h inf )d13周重复6、IM2i.v.

28、 (30min inf ,MesnaIfosfamide2000mg/m保护d1-3Mitoxantrone210mg/mi.v. (30min inf )d134周重复7、脂质体ADM脂质体ADM250mg/mi.v. (1h inf )d14周重复十二、绒毛膜癌低危1、MethorexateMethorexate0.40.6mg/kgi.m.或 i.v. (bolus )d1-5周重复2、DactinomycinDactinomycin1012ug/kgi.v.(bolus )d1-5周重复高危1、EMA-COEtoposide.一.2100mg/mi.v.11h inf )d1-2Met

29、horexate2100mg/mi.v.d12200mg/mi.v.(12h inf )d1Dactinomycin20.5mg/mi.v.(bolus )d1-2Cyclophosphamide2600mg/mi.v.(30min inf )d8Vincristine21.0mg/mi.v.(bolus )d83周重复2、 MACMethorexate0.3mg/kgi.m.d1-5Dactinomycin810ug/kgi.v.(bolus )d1-5Cyclophosphamide250mgi.v.(bolus )d1-5Chlorambucil0.2mg/kgp.o.d1-523周重复

30、3周重复3、挽救治疗低危1、EAEtoposide2100mg/mi.v.11h inf )d1-3Dactinomycin20.5mg/mi.v.(bolus )d1-310大重复高危1、EP/EMAEPEtoposide2150mg/mi.v.(30min inf )d1Cisplatin275mg/mi.v.(4h inf )d1EMAEtoposide,“,2100mg/mi.v. (30min inf)d1Methorexate . 2300mg/mi.v. 112h inf )d1Dactinomycin0.5mgi.v. (bolus )d1Folinic acid15mgbid

31、 ,p.o.或 i.m.(MT新 24h, q6h*4 )d2,3EP/EMA每周交替十三、生殖细胞恶性肿瘤一非精原细胞瘤1、BEPBleomycin230mg/mi.v.b bolus )d1,8,15Etoposide2100mg/mi.v.(1h inf )d1-5或 165mg/mi.v.(1h inf )d1-3Cisplatin250mg/mi.v.d1-2或 20mg/n2i.v.d1-53周重复2、ACEDactinomycin0.5mgi.v.(bolus )d1-3Cyclophosphamide2500mg/mi.v.(30min inf )d3Etoposide2100

32、mg/mi.v.(1h inf )d1-34周重复3、VIPEtoposide2200mg/mi.v.(1h inf )d1-5Ifosfamide21600mg/mi.v.(1h inf , Mesna 保护) d1-5Cisplatin230mg/mi.v.(1h inf )d1-53周重复,G-CSF支持4、 T-BEPPaclitaxel2175mg/mi.v.(1h inf )d1Bleomycin30mgi.v.(bolus )d1,8,15Etoposide2200mg/mi.v.(1h inf )d1-5Cisplatin230mg/mi.v.(1h inf )d1-53周重复

33、,G-CSF支持5、VeIPVinblastine0.11mg/kgi.v.(bolus )d1-22i.v.(1h inf , MesnaIfosfamide1200mg/m保护d15Cisplatin20mg/m2i.v.3 30min inf )d153周重复6、TIPPaclitaxel 2250mg/mi.v.(24h inf )d1Ifosfamide21200mg/mi.v.(1h inf , Mesna 保护) d2-6Cisplatin220mg/mi.v.30min inf)d2-63周重复,G-CSF支持二精原细胞瘤EP1、BEPEtoposide2100mg/mi.v.

34、(1h inf )d1-5Cisplatin220mg/mi.v.30min inf)d1-53周重复2、VeIPVinblastine0.11mg/kgi.v.(bolus )d1-2Ifosfamide21200mg/mi.v.保护)(1h inf ,Mesnad15Cisplatin220mg/mi.v.30min inf)d153周重复十四、原发不明转移瘤1 、 TCEPaclitaxel2200mg/mi.v.(1h inf )d1CarboplatinAUC=6i.v.2030mininf )d1Etoposide50mgp.o.d1,3,5,7,9100mgp.o.d2,4,6,

35、8,103周重复2、PEBBleomycin30mgi.v.(bolus )d1,8,15Etoposide2100mg/mi.v.(1h inf )d1-5Cisplatin220mg/mi.v.d153周重复3、 DCDocetaxel265mg/mi.v.d1CarboplatinAUC=6i.v.d13周重复4、TFLPaclitaxel.L,2175mg/mi.v.(3h inf )d1Folinic acid300mgi.v.(3060min inf)d1-35-Fluorouracil2350mg/mi.v.(3060min inf)d1-34周重复5、VACVinblastin

36、e1.4mg/m2i.v.d1Doxorubicin50mg/m2i.v.d1Cyclophosphamide2500mg/mi.v.d13周重复十五、恶性黑色素瘤1、DacarbazineDacarbazine28501000mg/mi.v.d1或者2250mg/mi.v.d1-534周重复2、FotemustineFotemustine2100mg/mi.v.(1h inf )d1,8,153周重复3、 VindesineVinblastine3mg/m2i.v.d12周重复,共1年；然后3周重复,共6月；最后4周重复,共6月4、低剂量IFNInterferon alpha3MUs.c.t

37、iw6-36 月5、中剂量IFNInterferon alpha10MUs.c.5天/周4周；然后5MUs.c.tiw2年6、高剂量IFNInterferon alpha20MU/m2i.v.或5天/周4周；然后2 10MU/m2s.c.tiw48周7、Interleukin-2Interleukin-2600000 或 720000IU/kgi.v.(15min)每8小时一次,共 14次,2周重复；假设耐殳,612周为一疗程,最多5疗程8、Dartmouth 方柔Cisplatin225mg/mi.v.(3045min inf)d1-3BCNU2150mg/mi.v.(short inf )

38、d1Dacarbazine220mg/mi.v.(short inf )d1-3Tamoxifen2040mgp.o.化疗前1周开始3周重复9、DVPDacarbazine 2250mg/mi.v.(30min inf )d1-5Vindesine23mg/mi.v.(bolus )d1,8,15Cisplatin2100mg/mi.v.(30min inf )d14周重复10、Dacarbazine+Interferon alphaDacarbazine2800mg/mi.v.(short inf )d1Interferon alpha9MUs.c.tiw3周重复11、Dacarbazine

39、+Cisplatin+Interferon alpha+Interleukin-2Dacarbazine2250mg/mi.v.(30min inf )d1-3Cisplatin225mg/mi.v.(1h inf )d1-3Interferon alpha25MU/m2s.c.d6,8,10,13,15Interleukin-2218MU/m2i.v.(15min inf )d6-10,13-154周重复十六、恶性间皮瘤1、EpirubicinEpirubicin2110mg/mi.v.(bolus )d13周重复2、VinorelbineVinorelbine230mg/mi.v.(5min inf )qw6周升-疗程3、APDoxorubicin60mg/m2i.v.(bolus )d1Cisplatin260mg/mi.v.(1h inf )d134周重复4、GPGemcitabine21000mg/mi.v.(30min inf )d1,8,15Cisplatin2100mg/mi.v.2h inf )d14周重复十七、神经内分泌癌1、DoxorubicinDoxorubicin“,260mg/mi.v.(bolus )d134周重复2