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1、Simultaneous determination of thirty non-steroidal anti-inflammatory drugresidues in swine muscle by ultra-high-performance liquid chromatography withtandem mass spectrometryxxxx大学xxx201x.xx.xx1.Simultaneously analyze 30 NSAIDs2.Complex matrix: swine muscle3. New detection method: UHPLC/MC/MCMajor A

2、dvantages:Sample Preparation:5 g swine muscle 15mL acidic acetonitrile2 g anhydrous sodium sulfate15 mL n-hexane saturated with acetonitrileN2, 5mL methanolphosphoricacidHLB cartridge4 mL ammonium hydroxideacetonitrilemethyl tert-butylether4 mL methyl tert-butyl etherN2, 1 mL acetonitrile0.1% formic

3、 acidmembrane filterUHPLC/MC/MCOptimization of extraction procedure:Method Validation:1. LOD: 0.4-2.0 g/kg2. LOQ: 1.0-5.0 g/kg 3. Recoveries：61.7% - 125.7%4. Precision: repeatability8%5. Linearity: r0.9900 Real sample analysis100 import swine muscle samples7% positive rateketoprofenacetaminophensali

4、cylic acidaminoantipyrineConclusions1.This study applied UHPLCMS/MS to establish a method for simultaneous determination of multi-residue of thirty non-steroidal anti-inflammatory drugs in swine muscle.2.Extraction and purification conditions for multi-residue analysis in animal original food products werein-depth discussed.3.This method was reliable, convenient and sensitive. Mo