靶向联合放疗-王平

1、14%16%25%45%National Cancer Institute:SEER Cancer Statistics Review,1973-1998肺癌诊断时的分期肺癌诊断时的分期Dillmao RO，et al.J Nail Cancer Inat,1996.Inculet R，et al.lung cancer，1997nEpidermal growth factor receptor blockade with C225 modulates proliferation，apoptosis，and radioscnsitivity in squamous cell carcinoma

2、s of the head and neckJCancer Res，1999，59：19351940nModulation of radiation response and tumorinduced angiogenesis after epiderm al growth factor receptor inhibition by ZD1839(Iressa)JCancer Res，2003，62：4300-4306nMec han ismsof enhan ced radiation response following epiderm al growth factorreceptor s

3、ignalinginhibition by Erlotinib(Tarceva)JCancer Res，2005，65：3328-3335观察组Erlotinib 组单纯放疗组联合治疗组单纯放疗与联合治疗放射敏感性参数的不同：单纯放疗与联合治疗放射敏感性参数的不同：天津医科大学附属肿瘤医院放疗科天津医科大学附属肿瘤医院放疗科 孙健博士论文，孙健博士论文，2009Bonner JA, et al. N Engl J Med 2006:354(6):567-78. 没有转移的没有转移的III-IV期头颈期头颈部鳞癌病人部鳞癌病人放射治疗放射治疗70-76.8Gy，共，共 213例例放射治疗放射治疗

4、70-76.8Gy， 共共211例例C225 400mg/m2放疗前一周放疗前一周C225 250mg/m2C225 250mg/m2放疗期间每周一次放疗期间每周一次随机分组局部区域控制率局部区域控制率总生存率总生存率Bonner JA, et al. N Engl J Med 2006:354(6):567-78. 入入选选病病人人放射治疗放射治疗63Gy/35次次400mg/m2250mg/m2每周一次至治疗结束共每周一次至治疗结束共16次次250mg/m2250mg/m2250mg/m2250mg/m2250mg/m2250mg/m2250mg/m2C225CBP: AUC= 2; TX

5、T: 45mg/m2化疗共化疗共6次次 放疗化疗Komaki R, ASTRO 2007Blumenschein GR, ASCO 2008Blumenschein GR, ASCO 2008HoshiS，YamaguchiT.Recurrence of Non-small-cell lung cancer after successful treatment with Gefitinib report of three cases,Gan To Kagaku Ryoho，2004，31(5):1209一121 Hideshi Sugiura MD, Kenji Yamada MD,Takah

6、iko Sugiura MD，et al. Predictors of Survival in Patients With Bone Metastasis of Lung Cancer.Clin Orthop Relat Res (2008) 466:729736. Hiroaki Satoh ，Hiroichi Ishikawa ，Gen Ohara，et al. Prolonged response to gefitinib in bone metastasis，Med Oncol， 2009， 26:101102.Salvatierra A, Baamonde C, Llamas JM, Cruz F, Lopez-Pujol J. Extratorasic staging of bronchogenic carcinoma. Chest 1990;97:1052-8.Hiroaki Satoh. Synchronous lung and bone metastasis in lung cancer Archive of Oncology 2003;11(1):39.Hideshi Sugiura MD, Kenji Yamada MD,Takahiko Sugiura MD，et al. Pre