医学免疫学英语试题

1、IChooseonewhichisthebestanswerineachquestion(40x1point=40)1. Immunologicalunresponsivenesstoselfantigensiscalled:(A)AToleranceBTolerogenCMemoryDAcquiredimmunity2. ThesignaltransductionmoleculesassociatedwithBCRare(B)A.CD21andCD81.B.IgendIgpD79a,bC.IgDandIgM.D.ITAMsandITIMs.3. TcellsareMHC-restricted

2、intheirabilitytorespondtoantigenbecause(DA. allantigenmustbeprocessedandpresentedtoactivatelymphocytes.B. duringaninfection,allcellsinthebodypresentantigenonMHCClassI.C. MHCbindsantigenmorespecificallythanTCRdoes.D. TCRmustrecognizebothantigenandMHCmolecules.4. AnantibodyFabcontains(AB)A.complementa

3、ritydeterminingregions.B.HandLchainvariableregions.C.oneantigenbindingregion.D.oneH-Linterchaindisulfidebond.5. Positiveselectioninthethymusismediatedby:(A)AThymicepithelialcells.BMacrophages.CDendriticcells.DB-cells.6. TypeIVhypersentivityisoftenreferredtoa：B)A.ImmediatehypersensitivityB.Delayedhyp

4、ersensitivityC.CytotoxichypersensitivityD.Allergichypersensitivity7. TypeHhypersentivityisoftfenrregdtoas:(C)A.ImmediatehypersensitivityB.DelayedhypersensitivityC.CytotoxichypersensitivityD.Allergichypersensitivity8. NaiveBcellexpresses(C)A.IgAaloneB.IgAandIgGCIgM+IgDD.IgEandIg9. Tcell-derivedcytoki

5、nes(D)A. areantigen-specificproductsofTcellactivation整理范本B. arestoredintherestingTcellandreleasedonactivationC. areMHC-restrictedintheireffectsD. influencetheclassofantibodiesproducedbyBcell10. NeutrophilsareattractedtoaninfectedareabyC)A.IgMB.C1C.C5aD.C811. Complementlysescellsby(C)A. enzymaticdige

6、stionofthecellmembraneB. activationofadenylatecyclaseC. insertionofcomplementproteinsintothecellmembraneD. inhibitionofelongationfactor212. CD8isamarkerof(C)A.BcellsB.Helper-TcellsC.cytotoxicTcellD.M小13. MHCclassHmoleculesarefoun(Bon)A.VirtuallyallcellsinthebodyB.Bcells,DCandM小C.Virtuallyallnucleate

7、dcellsinthebodyD.Onlyonvirally-infectedcells.14. AlloffollowingcytokinesaresecretedbyTh2cellsexcepB)A.IL-4B.IFN-TC.IL-5D.IL-615. WhichofthefollowingisNOTtrueofCD4+andCD8+cellmarkers?(D)A. ThesearebothsurfaceglycoproteinsexpressedonT-cells.B. TheseservetodistinguishdifferenttypesofT-cells,e.g.,helper

8、,suppressorandcytotoxic,fromeachother.C. Thesearenotfoundassociatedwithimmunoglobulins.D. BothofthemarkersarepresentonALLT-cells.16. CellsbearingMHCclassIpluspeptidearetargetsforspecifiB)AB-cells.BCytotoxicT-cells.CTh1cells.DTh2cells.17. Dendriticcellsarecharacterizedby:(D)整理范本Athepresenceofmajorbas

9、icproteinBexpressionofCD3CexpressionofIgMmoleculesDtheirinterfacebetweentheinnateandadaptiveimmunesystem18. WhichofthefollowinguniquelydistinguishestheT-cellreceptor(TCR)fromanantibody?(A)A. TheTCRcanbindanantigenfragmentonlyinatrimolecularcomplexwitheithertheclassIorclassIIsurfaceproteinsofthemajor

10、histocompatibilitycomplexB. TheTCRcanfunctionasacellsurfaceantigenreceptorC. TheTCRiscomposedoftwodifferenttypesofpolypeptidechainsD. TheTCRiscapableofparticipatinginacytotoxicreaction.19. Acriticalpropertyofanantigenis(A)A. ItsabilitytostimulateanimmuneresponseB. auniquetopologicalfeaturecalledanpa

11、ratopeC. notauniquetopologicalfeaturecalledanantigenicdeterminantD. thesizeofwhichisrelativelysmall20.Opsonizationofbacteriaoccursthroughcoatingbacteriajustwith(:A)AC3bBC8CMembraneattackcomplexDIgM21. ThefollowingischaracteristicofB-butnotT-cells:(D)AClassIMHC.BCD3.CHIVvirusreceptor.DSurfaceimmunogl

12、obulin.22. WhichofthefollowingmoleculesisexpressedonthesurfaceofmatureCDtells?(C)整理范本A.BcellreceptorB.CD1dC.CD3D.CD823. Thethymusisthesiteofinitialdifferentiationfor(D)A.BcellsB.ErythrocytesC.HematopieticstemcellsD.Tcells24. Themembraneattackcomplexconsistsof:(C)AOHBC3b3b,BbCC5b,6,7,8,9DProperdin25.

13、 TypeIhypersentivityisoftenreferredto(As:)A.ImmediatehypersensitivityB.DelayedhypersensitivityC.CytotoxichypersensitivityD.Immunecomplexhypersensitivity26. Typemhypetrsityisoftenreferredtoas:(D)A.ImmediatehypersensitivityB.DelayedhypersensitivityC.CytotoxichypersensitivityD.Immunecomplexhypersensiti

14、vity27. ThetypeIhypersentivityismediatedDby：A.IgAB.IgDC.IgGD.IgE28. ThecytokinewhichismostinvolvedintheclassswitchtoIgEproductionis(D)A.IL-1B.IL-2C.TGFbetaD.IL-429. WhichtypehypersensitivityisrelatedtothemechanismofacuteArthusreaction:(C)A.TypeIhypersentivityB.TypeHhypersentivityC.Typemhypersentivit

15、yD.TypeIVhypersentivity30. T-cellCD40LprovidesacostimulatorysignaltoB-cellsbyligating(:A)ACD40BMHCclassIICCD28DCD1931. Whichimmunoglobulincanbetransportedthroughtheplacenta?A)整理范本A.IgGB.IgMC.SecretoryIgAD.IgE32. Whichimmunoglobulinisthemostoneintheblood?(A)A.IgGB.IgMC.SecretoryIgAD.IgE33. Whichimmun

16、oglobulincanmediatetheimmediatehypersensitivity?(D)A.IgGB.IgMC.SecretoryIgAD.IgE34. MoleculesdirectlyinvolvedinNKcellmediatedkillinginclude:(B)AnitricoxideBgranzymeCcomplementDIFN-丫35. Immunecomplexesconsistof(C)A.antibodypluscomplementB.basophilpluscomplementC.antigenplusantibodyD.antigenpluscomple

17、ment36. ThemaincostimulatorysignalforactivationofrestingT-cellsisprovidedbyligationof:(A)ACD28BSurfaceIgCLFA-1DVLA-437. TheT-cellreceptorantigenrecognitionsignalistransducedby:E)ATheTCRalphachain.BTheTCRbetachain.DCD2.ECD3.38. TheT-cellligandbindingB7onaprofessionalantigen-presentingcell阻ACD28BCD2CL

18、FA-1DICAM-139. SecondaryantibodyresponsesarebetterbecausC)(ATheyprovidedefenseagainstunrelatedantigensBTheantibodycanbemadebybothTandBcellsCTheyarestrongerandfaster整理范本DTheydonotrequireT-cellhelp40. Whichcelltypeproducesantibodies?(D)AMacrophagesBT-lymphocytesCNKDPlasmacellsII.Indicatewhethereachoft

19、hefollowingstatementsistrueorfalse.(10X2points=20)1. Ahaptencanstimulateantibodyformationbutcannotcombinewithantibodymolecules.(F)2. Boostershotsarerequiredbecauserepeatedexposuretoanantigenbuildsastrongerimmuneresponse.(T)3. TheIga/IgBheterodimerandCD3serveanalogousfunctions-cethreceptorandT-cellre

20、ceptor,respectively.(T)4. Antigen-presentingcellsexpressbothclassIandclassIIMHCmoleculesontheirmembranes.(T)5. BabiescanacquireIgE-mediatedallergiesbypassivetransferofmaternalantibody.(F)6. BothCTLsandNKcellsreleaseperforinafterinteractingwithtargetcells.(T)7. Targetcelllysisanddestructioncanbeachie

21、vedbyperforinreleasedfromantigen-specificcytotoxicT-cells(T)8. Theimmuneresponseismediatedviathehumoraland/orcellulararmsoftheimmunesystem(T)9. ImmediatetypehypersensitivityismediatedbyIgM(F)10. Allcytokine-bindingreceptorscintaintwoorthreesubunits.(T)整理范本mAnswerthefollowingquestionsinbrief(10x4points=40)1. NamethethreetypesofprofessionalAPCs,andgiveoneexampleofnonprofessionalAPCs.BMDCendothelialcell2. Summarizethefourmajorfunctionsofcomplementsystemlysisofcells,bacteriaandvirusesopsonizationtoenhancephagocytosisclearanceofimmunecomplexes®stimulationofinflammation3. ListtheclassicalCla