重组人骨形态发生蛋白 2作用机制 - Medchemexpress - MCE中国

1、Product Data SheetRecombinant Human Bone Morphogenetic Protein 2Cat. No.: HY-P7006Synonyms: rHuBMP-2; BMP2A; BMP-2A; BMP2Species: HumanSource: E. coliAccession: P12643Gene ID: 650Molecular Weight: Approximately 26 kDaPROPERTIESAA SequenceMQ A K H K Q R K R L K S S C K R H P L Y V D F S D V GWN DW I

2、V A P P G Y H A F Y C H G E C P F P L A D H L N S T N H A I V Q T L V N S V N S K I P K A C C V P T E L S A I S M L Y L D E N E K V V L K N Y Q DM V V E G C G C RBiological Activity The ED50 is 70-200 ng/mL as measured by ATDC-5 cells.Appearance Lyophilized powder.Formulation Lyophilized after exten

3、sive dialysis against 50 mM acetic acid.Endotoxin Level 1 EU/g, determined by LAL method.Reconsititution Reconstitute the lyophilized recombinant Human Bone Morphogenetic Protein 2 (rHuBMP-2) to 100 g/mL using 20mM AcOH or diluted with 5 mM HCl.Storage & Stability Lyophilized recombinant Human Bone

4、Morphogenetic Protein 2 (rHuBMP-2) is stored at -20C. After reconstitution, itis stable at 4C for 2 weeks or -20C for longer. It is recommended to freeze aliquots at -20C or -80C for extendedstorage.Shipping Room temperature in continental US; may vary elsewhere.DESCRIPTIONBackground Recombinant Hum

5、an Bone Morphogenetic Protein 2 is a bone morphogenetic protein, effective in bone fracturehealing, and shortens the consolidation phase. Recombinant Human Bone Morphogenetic Protein 2 is a therapeuticoption in the treatment of several congenital and acquired craniofacial defects1. Recombinant Human

6、 BoneMorphogenetic Protein 2 (rhBMP-2) products have been approved by FDA and the European Medicines Agency andhas some clinical success for bone repair2.Page 1 of 2 www.MedChemEREFERENCES1. Herford AS. The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillofacial trauma. Chin

7、 J Traumatol. 2017 Feb;20(1):1-3.2. Qi X, et al. Synergistic effects of dimethyloxallyl glycine and recombinant human bone morphogenetic protein-2 on repair of critical-sized bone defectsin rats. Sci Rep. 2017 Feb 23;7:42820.McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.Tel: 400-820-37