Dimesna-BNP-7787-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDimesnaCat. No.: HY-B1022CAS No.: 16208-51-8Synonyms: BNP-7787分式: CHNaOS分量: 326.34作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 68 mg/mL (208.37 mM; Need ultrasonic

2、and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.0643 mL 15.3214 mL 30.6429 mL5 mM 0.6129 mL 3.0643 mL 6.1286 mL10 mM 0.3064 mL 1.5321 mL 3.0643 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Dimesna与癌症化疗药物联合使以降低尿毒性。REFERENCES1. Parker AR, et al. BNP7787-mediate

3、d modulation of paclitaxel- and cisplatin-induced aberrant microtubule protein polymerization in vitro.1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEMol Cancer Ther. 2010 Sep;9(9):2558-2567.2. Hausheer FH, et al.Mechanistic study of BNP7787-mediated cisplatin nephroprotection: modulation of gamma

4、-glutamyl transpeptidase.Cancer Chemother Pharmacol. 2010 Apr;65(5):941-951.3. Cutler MJ, et al. In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna. J Clin Pharmacol.2012 Apr;52(4):530-542.4. Habs MR,et al. Prevention of urinary bladder tumors in cyclo

5、phosphamide-treated rats by additional medication with the uroprotectorssodium 2-mercaptoethane sulfonate (mesna) and disodium 2,2-dithio-bis-ethane sulfonate (dimesna). Cancer. 1983 Feb 15;51(4):606-609.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5895