plus-Sparteine _nAChR 抑制剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE(+)-SparteineCat. No.: HY-W008350CAS No.: 492-08-0分式: CHN分量: 234.38作靶点: nAChR作通路: Membrane Transporter/Ion Channel; Neuronal Signaling储存式: Pure form -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 H2O : 2.86

2、mg/mL (12.20 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 4.2666 mL 21.3329 mL 42.6658 mL5 mM 0.8533 mL 4.2666 mL 8.5332 mL10 mM 0.4267 mL 2.1333 mL 4.2666 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 (+)-Sparteine种天然物碱，作为种神经节阻滞剂。在神经细胞中，(+)-Sparteine

3、 竞争性地抑制烟碱型酰胆碱受体 (nACh receptor) 活性。IC50 & Target AChR 1体外研究(+)-Sparteine (2 M) reduces the ACh-induced current caused by activation of nicotinic AChRs in a voltage-independent manner. (+)-Sparteine (5, 10 M) reduces the amplitude of the excitatory postsynaptic current1/2 Master of Small Molecules 您边

4、的抑制剂师www.MedChemE(EPSC) and the time constant of the EPSC decay 1.REFERENCES1. Voitenko S, et al. Effect of (+)-sparteine on nicotinic acetylcholine receptors in the neurons of rat superior cervical ganglion. MolPharmacol. 1991 Aug;40(2):180-5.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021