Pyridoxal-isonicotinoyl-hydrazone-PIH-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPyridoxal isonicotinoyl hydrazoneCat. No.: HY-114758CAS No.: 737-86-0Synonyms: PIH分式: CHNO分量: 286.29作靶点: Others作通路: Others储存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性数据体外实验 DMSO

2、: 14.71 mg/mL (51.38 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.4930 mL 17.4648 mL 34.9296 mL5 mM 0.6986 mL 3.4930 mL 6.9859 mL10 mM 0.3493 mL 1.7465 mL 3.4930 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内

3、实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 1.47 mg/mL (5.13 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 1.47 mg/mL (5.13 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil

4、Solubility: 1.47 mg/mL (5.13 mM); Suspended solution; Need ultrasonic1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 Pyridoxal isonicotinoyl hydrazine (PIH)种亲脂的三价铁螯合剂，显出铁螯合作 1。REFERENCES1. Hermes-Lima M, et al. The iron chelator pyridoxal isonicotinoyl hydrazone (PIH) and its

5、 analogues prevent damage to 2-deoxyribosemediated by ferric iron plus ascorbate. Biochim Biophys Acta. 2000 Oct 18;1523(2-3):154-60.2. Landschulz W, et al. A lipophilic iron chelator can replace transferrin as a stimulator of cell proliferation and differentiation. J Cell Biol.1984 Feb;98(2):596-601.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021