RRx-001-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERRx-001Cat. No.: HY-16438CAS No.: 925206-65-1分式: CHBrNO分量: 268.02作靶点: Parasite作通路: Anti-infection储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (373.11 mM)* means soluble, but sa

2、turation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.7311 mL 18.6553 mL 37.3107 mL5 mM 0.7462 mL 3.7311 mL 7.4621 mL10 mM 0.3731 mL 1.8655 mL 3.7311 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以

3、根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (9.33 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (9.33 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small Molecul

4、es 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (9.33 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 RRx-001种有效的葡萄糖-6-磷酸脱氢酶 (G6PD) 抑制剂。 RRx-001具有强抗疟效果, 药物敏感性测试表明,抑制寄活性IC50 = 0.14 ug/ml。户使本产品发表的科研献 Mol Cell. 2019 Aug. J Exp Clin Cancer Res. 2019 Feb 20;38(1):90.See more customer validations on HYPERLINK / www

5、.MedChemEREFERENCES1. Yalcin O, et al. From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria. Malar J. 2015 May28;14:218.2. Scicinski J, et al. Preclinical evaluation of the metabolism and disposition of RRx-001, a novel investigative anticancer agent. DrugMetab Dispos. 2012 Sep;40(9):1810-1816.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0