MC-DOXHZN-hydrochloride-Doxorubicin-6-maleimidocaproyl-hydrazone-hydrochloride-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMC-DOXHZN hydrochlorideCat. No.: HY-16261BCAS No.: 480998-12-7Synonyms: Doxorubicin(6-maleimidocaproyl)hydrazone hydrochloride分式: CHClNO分量: 787.21作靶点: Topoisomerase; ADC Cytotoxin作通路: Cell Cycle/DNA Damage; Antibody-drug Conjuga

2、te/ADCRelated储存式: Please store the product under the recommended conditions inthe COA.溶解性数据体外实验 DMSO : 125 mg/mL (158.79 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.2703 mL 6.3515 mL 12.7031 mL5 mM 0.2541 mL 1.2703 mL 2.5406 mL10 mM 0.1270 mL 0.6352 mL 1.2703 mL请根据产品在不同溶

3、剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (2.64 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% S

4、BE-CD in saline)Solubility: 2.08 mg/mL (2.64 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 MC-DOXHZN hydrochlorideDoxorubicin 的蛋结合前药，具有酸敏感性 1。户使本产品发表的科研献 Mol Pharm. 2017 Nov 6;14(11):3739-3749. Mol Pharm. 2015 Jul 6;12(7):2217-28. Bioconjug Chem. 2017 Oct

5、 18;28(10):2530-2537. Int J Pharm. 2016 Oct 15;512(1):1-13. China Biotechnology. 2017, 37(4): 68-75.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Sevim Rollas, et al. Hydrazone, Amide, Carbamate, Macromolecular and Other Prodrugs of Doxorubicin. The Open Drug DeliveryJournal, 2008, 2, 77-85.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 02