Alprenolol-hydrochloride-RS-Alprenolol-hydrochloride-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAlprenolol hydrochlorideCat. No.: HY-B1517ACAS No.: 13707-88-5Synonyms: (RS)-Alprenolol hydrochloride; dl-Alprenolol hydrochloride分式: CHClNO分量: 285.81作靶点: 5-HT Receptor作通路: GPCR/G Protein; Neuronal Signaling储存式: Powder -20C 3 ye

2、ars4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (349.88 mM; Need ultrasonic)H2O : 50 mg/mL (174.94 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.4988 mL 17.4941 mL 34.9883 mL5 mM 0.6998 mL 3.4988 mL 6.9977 mL10 mM 0.3499 mL 1.7494 mL 3.4988 mL请根

3、据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 3 mg/mL (10.50 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (2

4、0% SBE-CD in saline)Solubility: 3 mg/mL (10.50 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 3 mg/mL (10.50 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Alprenolol盐酸盐个选择性的beta阻断剂，也是5-HT1A受体的拮抗剂。REFERENCES1. Schreiber R et al. Involvem

5、ent of 5-HT1A receptors in the anxiolytic action of S 14671 in the pigeon conflict test. Pharmacol BiochemBehav. 1995 Jun-Jul;51(2-3):211-5.2. Millan MJ et al. Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1Aautoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists. J Pharmacol Exp Ther, 1994 Jan, 2McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792